公开(公告)号：US20230201354A1

公开(公告)日：2023-06-29

申请号：US17998761

申请日：2021-05-14

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Hakan Demirci ,  Nicholas Kotov ,  Yichun Wang

IPC: A61K47/52 ,  A61K9/00 ,  A61K45/06 ,  A61K49/00 ,  A61K47/69 ,  C01B32/159

CPC classification number: A61K47/52 ,  A61K9/0019 ,  A61K45/06 ,  A61K9/0092 ,  A61K49/0095 ,  A61K49/0017 ,  A61K47/6929 ,  C01B32/159 ,  C01B2202/36 ,  C01B2202/34 ,  B82Y5/00

Abstract: Disclosed herein are compositions and methods for injecting compounds into a vitreous body. Carbon nanotubes can be functionalized with a variety of agents, such as therapeutic agents and/or diagnostic agents, which can be injected into a vitreous body for treatment or detection of ocular tumors such as retinoblastoma. The carbon nanotubes can effectively penetrate the ocular tumor, making them effective carriers for the therapeutic and/or diagnostic agents.

公开(公告)号：US11313001B2

公开(公告)日：2022-04-26

申请号：US16761686

申请日：2018-11-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Nicholas Kotov ,  Jeremy Scott VanEpps ,  Kevin Ward

IPC: C12Q1/689 ,  C12Q1/686

Abstract: Provided herein are compositions, systems, and methods for detecting microorganisms. In particular, provided herein are compositions, systems, and methods for rapid, multiplex detection of microorganism in unpurified biological samples.

公开(公告)号：US20230260680A1

公开(公告)日：2023-08-17

申请号：US18014244

申请日：2021-07-01

Applicant: The Regents of the University of Michigan

Inventor： Mark Hammig ,  Nicholas Kotov ,  Jing Lyu ,  Suneel Joglekar

IPC: H01B13/30 ,  H01B1/22

CPC classification number: H01B13/30 ,  H01B1/22

Abstract: A method of fabricating a conductor includes preparing an aramid nanofiber solution in which a matrix of aramid nanofibers is dispersed, preparing a dispersion of copper nanoparticles, each copper nanoparticle of the dispersion of cooper nanoparticles having an organic capping ligand attached to the copper nanoparticle, and incorporating copper nanoparticles of the dispersion of copper nanoparticles into the matrix of aramid nanofibers such that each incorporated copper nanoparticle is bonded to a respective aramid nanofiber of the matrix of aramid nanofibers via the organic capping ligand to which the copper nanoparticle is attached. The organic capping ligand may include a mercaptocarboxyiic acid.

公开(公告)号：US20230145015A1

公开(公告)日：2023-05-11

申请号：US17912834

申请日：2021-03-19

Applicant: The Regents of the University of Michigan

Inventor： Mark Hammig ,  Nicholas Kotov

IPC: H01L31/08 ,  G01T1/36 ,  H01L31/0224 ,  H01L31/0384 ,  H01L31/18

CPC classification number: H01L31/085 ,  G01T1/366 ,  H01L31/18 ,  H01L31/0224 ,  H01L31/0384

Abstract: A detector includes a substrate including a matrix of aramid nanofibers, a distribution of nanoparticles across the matrix of aramid nanofibers, and a plurality of organic capping ligands. Each organic capping ligand of the plurality of organic capping ligands bonds a respective nanoparticle of the plurality of nanoparticles to a respective aramid nanofiber of the matrix of aramid nanofibers. The detector further includes first and second electrodes disposed along opposite sides of the substrate to capture charges generated by photons or particles incident upon the detector. Each nanoparticle of the plurality of nanoparticles has a semiconductor composition.

公开(公告)号：US20210180117A1

公开(公告)日：2021-06-17

申请号：US16761686

申请日：2018-11-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Nicholas Kotov ,  Jeremy Scott VanEpps ,  Kevin Ward

IPC: C12Q1/689 ,  C12Q1/686

Abstract: Provided herein are compositions, systems, and methods for detecting microorganisms. In particular, provided herein are compositions, systems, and methods for rapid, multiplex detection of microorganism in unpurified biological samples.