公开(公告)号：US11203694B2

公开(公告)日：2021-12-21

申请号：US16545781

申请日：2019-08-20

Applicant: The Johns Hopkins University

Inventor： Christopher M. Hoffman, Jr. ,  Adam W. Freeman ,  Konstantinos Gerasopoulos ,  James K. Johnson ,  Felix C. Sage ,  Spencer A. Langevin ,  Reid E. Messersmith

IPC: C09D5/16 ,  C09D171/02 ,  C09D133/06

Abstract: An anti-fouling coating comprising a polymeric compound, wherein a backbone of the polymeric compound is covalently bonded to a quorum sensing inhibitor, and wherein the anti-fouling coating has substantially no bactericidal activity, the quorum sensing inhibitor is substantially non-leaching from the anti-fouling coating, or both.

公开(公告)号：US20230097635A1

公开(公告)日：2023-03-30

申请号：US17954744

申请日：2022-09-28

Applicant: The Johns Hopkins University

Inventor： Christopher M. Hoffman, Jr. ,  Brian M. Koronkiewicz ,  Reid E. Messersmith ,  Mairead E. Bartlett

IPC: B01J13/16 ,  C09J175/04 ,  C09J5/00 ,  B32B37/12 ,  B32B15/04 ,  B32B15/18

Abstract: A microcapsule for use with an underwater adhesive includes a shell including nanoclay platelets and a polyurea product of an interfacial polymerization of a polyamine and an aromatic polyisocyanate. The microcapsule further includes a core composition encapsulated by the shell. The core composition includes a base catalyst for formation of a polyurethane, a polyol, and a hydrophilic solvent.

公开(公告)号：US20220106255A1

公开(公告)日：2022-04-07

申请号：US17488435

申请日：2021-09-29

Applicant: The Johns Hopkins University

Inventor： Reid E. Messersmith ,  Scott A. Shuler ,  Mairead E. Bartlett

IPC: C07C69/78 ,  C07C51/363 ,  C07C67/10 ,  C07C67/313 ,  C07D209/46 ,  A61K47/54 ,  C08G61/12 ,  A61K49/00

Abstract: A bifunctional linker of Formula 1 wherein in Formula I, at least one of R1 to R4 is —COOR5 and R5 is —C0-C10alkyl(C2-C10alkynyl) or —C0-C10alkyl-C2-C10alkenyl(C2-C10alkynyl), preferably a terminal alkynyl. The bifunctional linker is used in a cycloaddition to tether two entities, for example a protein or antibody, and an active agent, to form a bisconjugate. The bifunctional linker also be used to form a conjugate, followed by cycloaddition in the presence of a comonomer composition to form a bisconjugate including a protein or antibody linked to an adhesive polymer network. Catalysis can be provided by a copper-containing paint on a surface to adhere the bisconjugate to the surface. Methods of synthesis and use of the bisconjugates imaging, diagnostic, and therapeutic applications are also described.

公开(公告)号：US20200248008A1

公开(公告)日：2020-08-06

申请号：US16545781

申请日：2019-08-20

Applicant: The Johns Hopkins University

Inventor： Christopher M. Hoffman ,  Adam W. Freeman ,  Kostantinos Gerasopoulos ,  James K. Johnson ,  Felix C. Sage ,  Spencer A. Langevin ,  Reid E. Messersmith

IPC: C09D5/16 ,  C09D133/06 ,  C09D171/02

Abstract: An anti-fouling coating comprising a polymeric compound, wherein a backbone of the polymeric compound is covalently bonded to a quorum sensing inhibitor, and wherein the anti-fouling coating has substantially no bactericidal activity, the quorum sensing inhibitor is substantially non-leaching from the anti-fouling coating, or both.