公开(公告)号：US20230051847A1

公开(公告)日：2023-02-16

申请号：US17783506

申请日：2020-12-17

Applicant: The Johns Hopkins University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  Emily Han-Chung Hsiue ,  Jacqueline Douglass ,  Michael S. Hwang ,  Alexander Pearlman ,  Nickolas Papadopoulos ,  Shibin Zhou ,  Brian Mog ,  Katharine M. Wright ,  Sandra B. Gabelli

IPC: C07K16/30 ,  C07K16/28 ,  A61P35/00

Abstract: This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

公开(公告)号：US20250034252A1

公开(公告)日：2025-01-30

申请号：US18715847

申请日：2022-12-15

Applicant: The Johns Hopkins University

Inventor： Bert Vogelstein ,  Kenneth W. Kinzler ,  Nickolas Papadopoulos ,  Shibin Zhou ,  Sarah DiNapoli ,  Emily Han-Chung Hsiue ,  Brian J. Mog ,  Katharine M. Wright ,  Sandra B. Gabelli

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/30

Abstract: Described herein are methods and compositions for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.