公开(公告)号：US10745424B2

公开(公告)日：2020-08-18

申请号：US16327735

申请日：2017-08-30

申请人： The Board of Trustees of The Leland Stanford Junior University

发明人： Noah Burns ,  Steven R. Shuken ,  Jaron A. M. Mercer ,  Carolyn M. Cohen

IPC分类号： C07F9/117 ,  C07C1/32 ,  C07C2/42 ,  C07C13/62 ,  C07C29/17 ,  C07C45/69 ,  C07C53/136 ,  C07C1/30 ,  C07C29/09 ,  C07C41/20 ,  C07C45/68 ,  C07C51/16 ,  C07C41/18 ,  C07C69/608 ,  A61K9/127 ,  C07C31/137 ,  C07C49/693 ,  C07F5/02

摘要： Methods for preparing a variety of ladderane precursors, ladderane compounds and ladderane lipids are provided. Also provided are methods of preparing a liposome from the ladderane lipids disclosed herein, and compositions thereof. Aspects of the invention include encapsulated one or more cargo moieties in the liposome or compositions thereof and use of the subject liposome compositions as vehicles in drug delivery, imaging, diagnostics and other medical applications. Aspects of the methods disclosed herein include administering a liposomal composition comprising a pharmaceutical agent to a subject under conditions sufficient to deliver the composition to a site of interest in the subject, and release the pharmaceutical agent from the liposomal composition.

公开(公告)号：US20190177347A1

公开(公告)日：2019-06-13

申请号：US16327735

申请日：2017-08-30

申请人： The Board of Trustees of The Leland Stanford Junior University

发明人： Noah Burns ,  Steven R. Shuken ,  Jaron A.M. Mercer ,  Carolyn M. Cohen

IPC分类号： C07F9/117 ,  A61K9/127 ,  C07C1/32 ,  C07C2/42 ,  C07F5/02 ,  C07C29/17 ,  C07C45/69 ,  C07C13/62 ,  C07C49/693 ,  C07C53/136 ,  C07C31/137

CPC分类号： C07F9/117 ,  A61K9/1271 ,  C07C1/30 ,  C07C1/322 ,  C07C2/42 ,  C07C13/62 ,  C07C29/09 ,  C07C29/095 ,  C07C29/172 ,  C07C31/137 ,  C07C41/18 ,  C07C41/20 ,  C07C45/68 ,  C07C45/69 ,  C07C49/693 ,  C07C51/16 ,  C07C53/136 ,  C07C69/608 ,  C07C2602/18 ,  C07C2603/40 ,  C07C2603/52 ,  C07F5/025 ,  C07C13/38 ,  C07C33/05 ,  C07C49/753 ,  C07C43/21

摘要： Methods for preparing a variety of ladderane precursors, ladderane compounds and ladderane lipids are provided. Also provided are methods of preparing a liposome from the ladderane lipids disclosed herein, and compositions thereof. Aspects of the invention include encapsulated one or more cargo moieties in the liposome or compositions thereof and use of the subject liposome compositions as vehicles in drug delivery, imaging, diagnostics and other medical applications. Aspects of the methods disclosed herein include administering a liposomal composition comprising a pharmaceutical agent to a subject under conditions sufficient to deliver the composition to a site of interest in the subject, and release the pharmaceutical agent from the liposomal composition.