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    Automated conversion between SFC and HPLC
    2.
    发明授权
    Automated conversion between SFC and HPLC 有权
    SFC和HPLC之间的自动转换

    公开(公告)号：US09163618B2

    公开(公告)日：2015-10-20

    申请号：US13530931

    申请日：2012-06-22

    申请人： Edwin E. Wikfors ,  Kimber D. Fogelman ,  Terry A. Berger

    发明人： Edwin E. Wikfors ,  Kimber D. Fogelman ,  Terry A. Berger

    IPC分类号： G01N1/00 ,  F04B11/00 ,  F04B23/06 ,  G01N30/32 ,  G01N30/34

    CPC分类号： F04B11/0075 ,  F04B23/06 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/326 ,  Y10T137/0352 ,  Y10T137/7722 ,  G01N2030/342 ,  B01D15/40

    摘要： An apparatus, system, and process of converting a standard, high performance liquid chromatography (HPLC) flow path to a flow path suitable for supercritical fluid chromatography (SFC) are described. This reversible technique is applied to a variety of flow configurations including binary, high pressure solvent mixing systems and quaternary, low pressure solvent mixing systems than can be conventionally operated or automated. The technique is generally applied to the fields of supercritical fluid chromatography and high pressure liquid chromatography, but users skilled in the art will find utility for any flow system where pressurization components must be periodically applied to and removed from both ends of a flow stream in an automated manner.

    摘要翻译： 描述了将标准的高效液相色谱（HPLC）流动路径转换到适用于超临界流体色谱（SFC）的流动路径的装置，系统和方法。 这种可逆技术应用于各种流动配置，包括二元，高压溶剂混合系统和四级，低压溶剂混合系统，比常规操作或自动化。 该技术通常应用于超临界流体色谱和高压液相色谱领域，但是本领域技术人员将发现对于任何流动系统都将发挥效用，其中加压组分必须周期性地施加到流动流的两端并从其中移除 自动化方式。

    Method of sample introduction for chromatographic systems
    4.
    发明授权
    Method of sample introduction for chromatographic systems 有权
    色谱系统样品引入方法

    公开(公告)号：US06576125B2

    公开(公告)日：2003-06-10

    申请号：US09931238

    申请日：2001-08-17

    申请人： Terry A. Berger ,  Kimber D. Fogelman

    发明人： Terry A. Berger ,  Kimber D. Fogelman

    IPC分类号： B01D1508

    CPC分类号： B01D15/166 ,  B01D15/14 ,  B01D15/40 ,  G01N30/02 ,  G01N30/22 ,  G01N30/34 ,  G01N30/36 ,  G01N2030/324 ,  G01N2030/347 ,  G01N30/16

    摘要： An improved method of introducing sample into a low-pressure flow stream of a high-pressure chromatography system to improve efficiency and significantly shorten the time of the separation process through a chromatography column is described. The method comprises injecting samples in a modifier liquid flow stream upstream of a mixing column that combines two independent flow streams of a liquid modifier with a highly compressed solvating fluid. Focusing can be controlled at the column head by changing the ratios of the two flow streams. Total flow may also be adjusted to speed the application of the sample onto the column during injection. The method improves the timing and efficiency of a supercritical fluid chromatography system and can reduce the amount of modifier added to the mobile phase flow stream.

    摘要翻译： 描述了将样品引入高压色谱系统的低压流动流以提高效率并显着缩短通过色谱柱的分离过程的时间的改进方法。 该方法包括将样品注入混合塔上游的改性剂液流流中，该混合塔将液体改性剂的两个独立流动流与高度压缩的溶剂化流体相结合。 可以通过改变两个流动流的比例来在柱头处控制聚焦。 也可以调整总流量以加速样品在注射期间在柱上的应用。 该方法提高了超临界流体色谱系统的时间和效率，并且可以减少添加到流动相流动流中的改性剂的量。

    Exhaust gas collection system for supercritical fluid chromatography
    5.
    发明授权
    Exhaust gas collection system for supercritical fluid chromatography 有权
    超临界流体色谱用废气收集系统

    公开(公告)号：US06558540B2

    公开(公告)日：2003-05-06

    申请号：US09917210

    申请日：2001-07-30

    申请人： Terry A. Berger ,  Kimber D. Fogelman ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    发明人： Terry A. Berger ,  Kimber D. Fogelman ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    IPC分类号： B01D1508

    CPC分类号： B01D11/0203 ,  B01D15/247 ,  B01D15/40 ,  G01N1/405 ,  G01N30/24 ,  G01N30/82

    摘要： An efficient and safe method and apparatus for collecting exhaust gasses in an open-air sample collection container in a supercritical fluid chromatography system is claimed. The invention uses a vacuum force to evacuate the gaseous phase and vapors separated from liquid mobile phase in a sample collection device. The invention is portable to use on a series of collection containers, such as test tubes or wells in a titration place. Embodiments are claimed for capture of gasses and vapors either internally or externally to a collection container. The invention removes the gasses from the collection container that are then safely vented to a waste collector, thereby creating a safer environment for the laboratory and properly removing and disposing potentially hazardous chemicals instead of venting these chemicals into the environment.

    摘要翻译： 一种用于在超临界流体色谱系统中的露天样品收集容器中收集废气的有效和安全的方法和装置。 本发明使用真空力来抽空样品收集装置中的气相和与液体流动相分离的蒸汽。 本发明便携式用于一系列收集容器，例如滴定处的试管或孔。 要求用于在收集容器的内部或外部捕集气体和蒸气的实施例。 本发明从收集容器中除去气体，然后将其安全地排放到废物收集器，从而为实验室创造更安全的环境，并适当地去除和处置潜在的危险化学品，而不是将这些化学物质排放到环境中。

    Method of sample introduction for supercritical fluid chromatography systems
    6.
    发明授权
    Method of sample introduction for supercritical fluid chromatography systems 有权
    超临界流体色谱系统样品引入方法

    公开(公告)号：US06428702B1

    公开(公告)日：2002-08-06

    申请号：US09918435

    申请日：2001-08-01

    申请人： Terry A. Berger ,  Kimber D. Fogelman

    发明人： Terry A. Berger ,  Kimber D. Fogelman

    IPC分类号： B01D1100

    CPC分类号： B01D15/14 ,  B01D15/40 ,  G01N30/02 ,  G01N30/16

    摘要： An improved method and apparatus for safely introducing sample into a flow stream of a supercritical fluid chromatography system is described. The sample injection method improves safety of injection by eliminating the risk of injecting sample into a high-pressure system containing liquids and gasses at or near supercritical ranges. The method improves the efficiency and significantly shortens the time of the injection process by using a check valve placed between a fill port on an injection valve and sample port where sample is injected by a syringe. After sample injection from a sample loop into a high-pressure flow stream, an injection valve is reset to receive a subsequent sample. High-pressure flow stream mixtures become trapped within the sample loop when the valve is reset. The check valve prevents the mixtures from expanding into the sample port and blowing out a syringe and flow stream mixtures from the fill lines. The trapped flow stream mixtures are directed to a waste port where they are safely contained. The technique can be applied equally as effective to preparatory SFC as well as to analytical SFC systems.

    摘要翻译： 描述了用于将样品安全地引入超临界流体色谱系统的流动流的改进的方法和装置。 样品注射方法通过消除在超临界范围内或附近含有液体和气体的高压系统中注入样品的风险，提高了注射的安全性。 该方法通过使用放置在注射阀上的填充口和通过注射器注射样品的样品端口的样品端口之间的止回阀来提高效率并显着缩短注射过程的时间。 从样品回路进样到高压流动流中后，重新注入进样阀以接收随后的样品。 当阀门复位时，高压流动流混合物将被捕获在样品回路内。 止回阀防止混合物膨胀到样品端口，吹出注射器并从填充线流出混合物。 被捕获的流动流混合物被引导到废物端口，在那里它们被安全地包含。 该技术可以同样适用于预备性证监会以及分析SFC系统。

    Automated sample collection in supercritical fluid chromatography
    7.
    发明授权
    Automated sample collection in supercritical fluid chromatography 有权
    超临界流体色谱自动样品采集

    公开(公告)号：US06685828B2

    公开(公告)日：2004-02-03

    申请号：US10119529

    申请日：2002-04-09

    申请人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    发明人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    IPC分类号： B01D1508

    CPC分类号： B01D11/0203 ,  B01D15/247 ,  B01D15/40 ,  G01N30/24 ,  G01N30/82

    摘要： A system for collection of liquid phase sample fractions from a supercritical fluid chromatography system is disclosed. The system has different ways of gathering the liquid phase into a collection chamber and provides for automated removal of liquid phase from a collection chamber into separate collection container. A separate pressure scheme is invoked upon the collection chambers to move liquid phase out of a chamber and into the separate collection container. In addition, the invention provides a renewal system for the collection chambers where each chamber returns to an uncontaminated stated by washing with a cleaning solution after removal of collected liquid phase. Spent cleaner from a chamber is purged using the pressure system into a waste stream for disposal.

    摘要翻译： 公开了一种用于从超临界流体色谱系统收集液相样品馏分的系统。 该系统具有将液相收集到收集室中并且提供将液相从收集室自动移除到单独的收集容器中的不同方式。 在收集室上引用单独的压力方案以将液相移出室并进入单独的收集容器。 此外，本发明提供了一种用于收集室的更新系统，其中每个室在去除收集的液相后通过用清洁溶液洗涤而返回到未污染的状态。 使用压力系统将来自室的废清洁剂清洗成废物流以便处理。

    Pump as a pressure source for supercritical fluid chromatography involving pressure regulators and a precision orifice
    8.
    发明授权
    Pump as a pressure source for supercritical fluid chromatography involving pressure regulators and a precision orifice 有权
    泵作为超临界流体色谱的压力源，包括压力调节器和精密孔

    公开(公告)号：US06648609B2

    公开(公告)日：2003-11-18

    申请号：US10117984

    申请日：2002-04-05

    申请人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    发明人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

    IPC分类号： F04B4908

    CPC分类号： F04B11/0091 ,  F04B49/225 ,  Y10T137/7838 ,  Y10T137/87917 ,  Y10T137/88054 ,  G01N2030/326 ,  B01D15/40

    摘要： The invention is a device and method in a high-pressure chromatography system, such as a supercritical fluid chromatography (SFC) system, that uses a pump as a pressure source for precision pumping of a compressible fluid. The preferred exemplary embodiment comprises a pressure regulation assembly installed downstream from a compressible fluid pump but prior to combining the compressible flow with a relatively incompressible modifier flow stream. The present invention allows the replacement of an high-grade SFC pump in the compressible fluid flow stream with an inexpensive and imprecise pump. The imprecise pump becomes capable of moving the compressible fluid flow stream in a precise flow rate and pattern. The assembly dampens the damaging effects of an imprecise pump, such as large pressure oscillations caused by flow ripples and noisy pressure signals that do not meet precise SFC pumping requirements.

    摘要翻译： 本发明是高压色谱系统中的装置和方法，例如超临界流体色谱（SFC）系统，其使用泵作为精密泵送可压缩流体的压力源。 优选的示例性实施例包括安装在可压缩流体泵的下游但在将可压缩流与相对不可压缩的修饰剂流动流组合之前的压力调节组件。 本发明允许用便宜且不精确的泵替代可压缩流体流动中的高级SFC泵。 不精确的泵变得能够以精确的流速和模式移动可压缩流体流动流。 该组件会抑制不精确泵的破坏性影响，例如由流动波纹引起的大压力振荡和不符合精确SFC泵送要求的噪声压力信号。

    System and process for an active drain for gas-liquid separators
    9.
    发明授权
    System and process for an active drain for gas-liquid separators 有权
    气液分离器主动排水系统及工艺

    公开(公告)号：US09114330B2

    公开(公告)日：2015-08-25

    申请号：US13825128

    申请日：2011-09-20

    申请人： Kimber D. Fogelman ,  Edwin E. Wikfors ,  Terry A. Berger

    发明人： Kimber D. Fogelman ,  Edwin E. Wikfors ,  Terry A. Berger

    IPC分类号： B01D19/00 ,  B01D15/10 ,  B01D15/40

    CPC分类号： B01D19/0036 ,  B01D15/10 ,  B01D15/40 ,  B01D19/0057 ,  B01D19/0063

    摘要： A device includes a gas-liquid separator that receives and separates a biphasic pressurized flow stream and delivers flow to at least one exit port enriched in vapor phase composition and at least one exit port enriched in liquid phase composition. The device further includes a low restriction inlet conduit in communication with the separator exit port enriched in liquid phase composition, and a positive displacement pump having an inlet port in communication with the inlet conduit to receive flow from the gas-liquid separator and an outlet port in communication with an outlet conduit.

    摘要翻译： 一种装置包括气 - 液分离器，其接收和分离两相加压流，并将流量输送至至少一个富含气相组成的出口和至少一个富含液相组成的出口。 该装置还包括与富含液相组合物的分离器出口连通的低限制入口导管，以及容积式泵，其具有与入口导管连通的入口端口，以接收来自气液分离器的流动和出口端口 与出口导管连通。