Patent search ap:("Terence Alfred Kelly" OR "Jin Mi Kim" OR "René Marc Lemieux") AND inv:"Jin Mi Kim" Page 1

1.

发明授权
Derivatives of [6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonylamino]-propionamide 有权
Title translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基氨基] - 丙酰胺的衍生物

公开(公告)号：US07589115B2

公开(公告)日：2009-09-15

申请号：US11872276

申请日：2007-10-15

Applicant: Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

Inventor： Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

IPC: A61K31/4162 , C07D403/02

CPC classification number: A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04

Abstract: Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Abstract translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。

2.

发明授权
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide 有权
Title translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基氨基] - 丙酰胺的衍生物

公开(公告)号：US07304067B2

公开(公告)日：2007-12-04

申请号：US11034701

申请日：2005-01-13

Applicant: Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

Inventor： Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

IPC: A61K31/505 , A61K31/4166 , C07D235/02 , C07D403/10

CPC classification number: A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04

Abstract: Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Abstract translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。

3.

发明授权
Derivatives of [6,7-dihydro-5H-imidazol[1,2-a]imidazole-3-sulfonylamino]-propionamide 有权
Title translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基氨基] - 丙酰胺的衍生物

公开(公告)号：US07345074B2

公开(公告)日：2008-03-18

申请号：US10969105

申请日：2004-10-20

Applicant: Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

Inventor： Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

IPC: A61K31/4166 , C07D235/02 , C07D403/02

CPC classification number: A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04

Abstract: Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Abstract translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰氨基] - 丙酰胺的衍生物，其对CAM和白细胞整合素的相互作用具有良好的抑制作用，因此可用于治疗炎性疾病。

4.

发明授权
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide 有权
Title translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基] - 吡咯烷-2-甲酸酰胺的衍生物

公开(公告)号：US06852748B1

公开(公告)日：2005-02-08

申请号：US10685638

申请日：2003-10-15

Applicant: Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux , Matt Aaron Tschantz

Inventor： Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux , Matt Aaron Tschantz

IPC: A61K31/4166 , A61K31/4188 , A61K31/5375 , A61P29/00 , C07D235/02 , C07D403/12 , C07D413/02 , C07D487/04

CPC classification number: C07D487/04 , A61K31/4188

Abstract: Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Abstract translation: 6,7-二氢-5H-咪唑并[1,2-α]咪唑-3-磺酰基] - 吡咯烷-2-甲酸酰胺的衍生物，其对CAM和白血球素蛋白的相互作用具有良好的抑制作用，因此可用于治疗炎症性疾病。

5.

发明授权
Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide 有权

公开(公告)号：US06844360B2

公开(公告)日：2005-01-18

申请号：US10686073

申请日：2003-10-15

Applicant: Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

Inventor： Terence Alfred Kelly , Jin Mi Kim , René Marc Lemieux

IPC: A61P37/00 , C07D487/04 , A61K31/4166 , C07D235/02 , C07D403/02

CPC classification number: A61K31/4166 , A61K31/506 , A61K31/5355 , C07D487/04

Abstract: Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

6.

发明授权
Pyrimidine derivatives useful as inhibitors of PKC-theta 有权
Title translation: 可用作PKC-θ抑制剂的嘧啶衍生物

公开(公告)号：US07601714B2

公开(公告)日：2009-10-13

申请号：US11175476

申请日：2005-07-06

Applicant: Antonio J. M. Barbosa, Jr. , Steven Richard Brunette , Eugene Richard Hickey , Jin Mi Kim , Michael David Lawlor , René Marc Lemieux , Bryan McKibben , Matt Aaron Tschantz , Hui Yu

Inventor： Antonio J. M. Barbosa, Jr. , Steven Richard Brunette , Eugene Richard Hickey , Jin Mi Kim , Michael David Lawlor , René Marc Lemieux , Bryan McKibben , Matt Aaron Tschantz , Hui Yu

IPC: C07D239/48 , C07D403/12 , A61K31/505

CPC classification number: C07D239/48 , C07D401/12 , C07D403/12

Abstract: Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Abstract translation: 公开了式（I）的新化合物：其中X，Y，R 1，R 2和R 3如本文所定义，其可用作PKC-θ的抑制剂，因此可用于治疗介导的多种疾病和病症通过PKC-θ的活性持续，包括免疫学障碍和II型糖尿病。本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

7.

发明授权
Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide 有权
Title translation: [6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基] - 吡咯烷-2-甲酸酰胺的衍生物

公开(公告)号：US07462637B2

公开(公告)日：2008-12-09

申请号：US10969698

申请日：2004-10-20

Applicant: Terence A. Kelly , Jin Mi Kim , René Marc Lemieux , Matt Aaron Tschantz

Inventor： Terence A. Kelly , Jin Mi Kim , René Marc Lemieux , Matt Aaron Tschantz

IPC: A61K31/4188 , A61K31/5375 , C07D235/02 , C07D403/12

CPC classification number: C07D487/04 , A61K31/4188

Abstract: Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Abstract translation: 6,7-二氢-5H-咪唑并[1,2-a]咪唑-3-磺酰基]吡咯烷-2-甲酸酰胺的衍生物，其对CAM和白血球素蛋白的相互作用具有良好的抑制作用，因此可用于治疗炎症性疾病。

8.

发明申请
Benzimidazolone Chymase Inhibitors 有权
Title translation: 苯并咪唑酮糜酶抑制剂

公开(公告)号：US20100240702A1

公开(公告)日：2010-09-23

申请号：US12596152

申请日：2008-05-15

Applicant: Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor

Inventor： Asitha Abeywardane , Brian Nicholas Cook , Stephane De Lombaert , Michel Jose Emmanuel , Xin Guo , Ming-Hong Hao , Jin Mi Kim , Ho Yin Lo , Chuk Chui Man , Tina Marie Morwick , Peter Allen Nemoto , Kevin Chungeng Qian , Hidenori Takahashi , Steven John Taylor

IPC: A61K31/454 , C07D235/26 , C07D211/32 , A61K31/4166 , A61P9/12 , A61P9/10 , A61P13/12

CPC classification number: C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04

Abstract: Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.

Abstract translation: 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。

9.

发明授权
Substituted benzylimidazoles useful for the treatment of inflammatory diseases 有权
Title translation: 用于治疗炎性疾病的取代的苄基咪唑

公开(公告)号：US07572921B2

公开(公告)日：2009-08-11

申请号：US11278558

申请日：2006-04-04

Applicant: Jin Mi Kim , Rene' Marc Lemieux , Bryan McKibben , Matt Aaron Tschantz , Hui Yu

Inventor： Jin Mi Kim , Rene' Marc Lemieux , Bryan McKibben , Matt Aaron Tschantz , Hui Yu

IPC: A61K31/4178 , A61K31/4164 , C07D233/64 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12

CPC classification number: C07D233/64 , C07D233/70 , C07D233/88 , C07D401/12 , C07D401/14

Abstract: The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions.

Abstract translation: 本发明包括一类式（I）的取代苄基咪唑衍生物及其制备方法。这些化合物可用于治疗炎性病症。