公开(公告)号：US11148138B2

公开(公告)日：2021-10-19

申请号：US15756176

申请日：2015-09-02

Applicant: TECAN TRADING AG ,  Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

Inventor： Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

IPC: B01L3/00

Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface, and a control unit for manipulating liquid droplets by electrowetting; providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface; providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads; moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit; actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads; and while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

公开(公告)号：US20230003685A1

公开(公告)日：2023-01-05

申请号：US17901634

申请日：2022-09-01

Applicant: TECAN TRADING AG

Inventor： Patrick KINNEY ,  Tin Ngo ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tiffany Ding (Lay)

IPC: G01N27/447 ,  B01L3/00

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.

公开(公告)号：US20240118239A1

公开(公告)日：2024-04-11

申请号：US18541491

申请日：2023-12-15

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tin Ngo ,  Tiffany Ding (Lay) ,  Torleif Ove Björnson

IPC: G01N27/447 ,  B01L3/00

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  G01N27/44747 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/048 ,  B01L2300/161 ,  B01L2400/0427

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.

公开(公告)号：US11951482B2

公开(公告)日：2024-04-09

申请号：US17559362

申请日：2021-12-22

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tiffany Ding (Lay) ,  Manjeet Dhindsa ,  Daniel Tran ,  Jennifer Ji ,  Sujata Iyer ,  Tin Ngo

IPC: B01L3/00

CPC classification number: B01L3/502792 ,  B01L2400/0427

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.

公开(公告)号：US11819845B2

公开(公告)日：2023-11-21

申请号：US17469656

申请日：2021-09-08

Applicant: TECAN TRADING AG

Inventor： Thomas Perroud ,  Dan Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/508 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/502792 ,  B01L2200/025 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2400/043 ,  B01L2400/0427

Abstract: A digital microfluidics system with electrodes attached to a substrate and covered by a hydrophobic surface and a control unit for manipulating liquid droplets by electrowetting, providing in close proximity to electrodes a magnetic conduit for directing a magnetic field of a backing magnet to the first hydrophobic surface, providing on the hydrophobic surface a liquid droplet that has magnetically responsive beads moving by electrowetting the liquid droplet with the magnetically responsive beads until a part of which is placed atop of the magnetic conduit, actuating the backing magnet of the magnetic conduit and attracting/concentrating magnetically responsive beads while actuating the backing magnet, moving by electrowetting the liquid droplet with decreased number of magnetically responsive beads away from the specific magnetic conduit. Also disclosed are a method for suspending magnetically responsive beads in liquid portions or droplets in digital microfluidics and a disposable cartridge to carry out the methods.

公开(公告)号：US20190331638A1

公开(公告)日：2019-10-31

申请号：US15962925

申请日：2018-04-25

Applicant: Tecan Trading AG

Inventor： Patrick Kinney ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tin Ngo ,  Tiffany Ding (Lay) ,  Torleif Ove Bjornson

IPC: G01N27/447 ,  B01L3/00

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having one or more inlet ports for introducing an input liquid into an internal gap of the cartridge, which has at least one hydrophobic surface for enabling an electrowetting induced movement of multiple microfluidic droplets separated from the input liquid. The cartridge further has at least one outlet port that is operably connected to the inlet port for providing a liquid flow through the cartridge, if a liquid driving force, in particular an electrowetting force or a pressure force, is applied to at least a part of the input liquid.

公开(公告)号：US20190329258A1

公开(公告)日：2019-10-31

申请号：US15962892

申请日：2018-04-25

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tiffany Ding (Lay) ,  Manjeet Dhindsa ,  Daniel Tran ,  Jennifer Ji ,  Sujata Iyer ,  Tin Ngo

IPC: B01L3/00

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.

公开(公告)号：US11933760B2

公开(公告)日：2024-03-19

申请号：US17901634

申请日：2022-09-01

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tin Ngo ,  Sujata Iyer ,  Daniel Hoffmeyer ,  Manjeet Dhindsa ,  Tiffany Ding (Lay)

IPC: G01N27/447 ,  B01L3/00

CPC classification number: G01N27/44791 ,  B01L3/502715 ,  G01N27/44739 ,  G01N27/44747 ,  B01L2200/027 ,  B01L2300/161 ,  B01L2400/0427

Abstract: A cartridge for use in an electrowetting sample processing system, the cartridge having at least one inlet port for introducing an input liquid in an internal gap of the cartridge, wherein the gap has at least one hydrophobic surface and is configured to provide an electrowetting induced movement of a microfluidic droplet of input liquid, wherein the input liquid has a carrier liquid and a processing liquid and the gap has a capture zone that is configured to capture at least a part of the processing liquid as a microfluidic droplet by use of electrowetting force and the gap further has a transfer zone that is configured to provide a passage for the carrier liquid next to the microfluidic droplet, while processing liquid is captured in the capture zone.

公开(公告)号：US20220111388A1

公开(公告)日：2022-04-14

申请号：US17559362

申请日：2021-12-22

Applicant: TECAN TRADING AG

Inventor： Patrick Kinney ,  Tiffany Ding (Lay) ,  Manjeet Dhindsa ,  Daniel Tran ,  Jennifer Ji ,  Sujata Iyer ,  Tin Ngo

IPC: B01L3/00

Abstract: A cartridge, in particular a disposable cartridge, for use in an electrowetting sample processing system. The cartridge has a liquid input port for introducing an input liquid into an internal gap of the cartridge, the input liquid providing for at least one droplet, directly or via a liquid separation process within the internal gap, and the internal gap having at least one hydrophobic surface, at least one processing zone for processing samples located in the processing zone, and a delivery zone for delivering the at least one droplet from the liquid input port to the at least one processing zone. The delivery zone is configured to provide a repeating pattern of interacting electrowetting force for simultaneously transporting the at least one droplet within the delivery zone.

公开(公告)号：US10913062B2

公开(公告)日：2021-02-09

申请号：US15756209

申请日：2016-09-01

Applicant: TECAN TRADING AG

Inventor： Thomas Perroud ,  Daniel Tran ,  Daniel Hoffmeyer ,  Tiffany Lay ,  Manjeet Dhindsa

IPC: B01L3/00

Abstract: Digital microfluidics system with electrodes attached to a PCB has control unit for manipulating liquid droplets by electrowetting, cartridge accommodation site for taking up a disposable cartridge having a working gap in-between two hydrophobic surfaces, and magnetic conduit/backing combination. A barrier element on an individual electrode of the PCB for narrowing the working gap. A disposable cartridge is positioned at the cartridge accommodation site, its flexible working film touching there and of the barrier element an uppermost surface. In the working gap and above a path of selected electrodes a liquid portion or liquid droplet with magnetically responsive beads moves by electrowetting on the electrode path until a magnetic field of the magnetic conduit is reached. The backing magnet is activated before and during the moving to thereby attract and remove magnetically responsive beads therefrom.