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    Implantable cardiac stimulation device and method that stabilizes ventricular rate during episodes of atrial fibrillation
    2.
    发明授权
    Implantable cardiac stimulation device and method that stabilizes ventricular rate during episodes of atrial fibrillation 有权
    可植入式心脏刺激装置及其在房颤发作期间稳定心室率的方法

    公开(公告)号：US08934971B1

    公开(公告)日：2015-01-13

    申请号：US11940174

    申请日：2007-11-14

    申请人： Euljoon Park ,  You-Ho Kim ,  Taraneh Ghaffari Farazi

    发明人： Euljoon Park ,  You-Ho Kim ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3624 ,  A61N1/3605 ,  A61N1/36053 ,  A61N1/365 ,  A61N1/368 ,  A61N1/395

    摘要： An implantable cardiac stimulation device and method provide electrical stimulation therapy to stabilize the ventricular rate of a heart during episodes of atrial fibrillation. The stimulation therapy may be a plurality of stimulation pulses delivered to the AV node during the AV node refractory period following the sensing of an atrial event. Alternatively, the stimulation therapy may be a plurality of sub-threshold stimulation pulses delivered to capture AV node vagal innervations following the detection of atrial fibrillation.

    摘要翻译： 可植入心脏刺激装置和方法提供电刺激治疗以在房颤发作期间稳定心脏心室率。 刺激治疗可以是在感觉心房事件之后的AV结节不应期期间传送到AV节点的多个刺激脉冲。 或者，刺激治疗可以是递送的多个次阈值刺激脉冲，以在检测心房颤动之后捕获AV节点迷走神经支配。

    System and method for monitoring diastolic function using an implantable medical device
    7.
    发明授权
    System and method for monitoring diastolic function using an implantable medical device 有权
    使用可植入医疗装置监测舒张功能的系统和方法

    公开(公告)号：US08280523B2

    公开(公告)日：2012-10-02

    申请号：US12341355

    申请日：2008-12-22

    申请人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    发明人： Allen Keel ,  Steve Koh ,  Taraneh Ghaffari Farazi

    IPC分类号： A61N1/36 ,  A61N1/378

    CPC分类号： A61N1/3702 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3712

    摘要： Diastolic function is monitored within a patient using a pacemaker or other implantable medical device. In one example, the implantable device uses morphological parameters derived from the T-wave evoked response waveform as proxies for ventricular relaxation rate and ventricular compliance. In particular, the magnitude of the peak of the T-wave evoked response is employed as a proxy for ventricular compliance. The maximum slew rate of the T-wave evoked response following its peak is employed as a proxy for ventricular relaxation. A metric is derived from these proxy values to represent diastolic function. The metric is tracked over time to evaluate changes in diastolic function. In other examples, specific values for ventricular compliance and ventricular relaxation are derived for the patient based on the T-wave evoked response parameters.

    摘要翻译： 使用起搏器或其他可植入医疗器械在患者体内监测舒张功能。 在一个示例中，可植入装置使用从T波诱发反应波形导出的形态参数作为心室松弛率和心室顺应性的代理。 特别地，T波诱发反应的峰值的大小被用作心室顺应性的代表。 其峰值后的T波诱发反应的最大压摆率被用作心室松弛的代用品。 来自这些代理值的度量来表示舒张功能。 随着时间的推移跟踪度量以评估舒张功能的变化。 在其他实例中，基于T波诱发反应参数为患者导出心室顺应性和心室松弛的具体值。

    Systems and methods for optimizing multi-site cardiac pacing and sensing configurations for use with an implantable medical device
    8.
    发明授权
    Systems and methods for optimizing multi-site cardiac pacing and sensing configurations for use with an implantable medical device 有权
    用于优化与可植入医疗装置一起使用的多部位心脏起搏和感测配置的系统和方法

    公开(公告)号：US08209010B2

    公开(公告)日：2012-06-26

    申请号：US12703069

    申请日：2010-02-09

    申请人： Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel ,  Taraneh Ghaffari Farazi ,  Xiaoyi Min

    发明人： Kyungmoo Ryu ,  Stuart Rosenberg ,  Allen Keel ,  Taraneh Ghaffari Farazi ,  Xiaoyi Min

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36514 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/3708

    摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped for multi-site left ventricular (MSLV) pacing using a multi-pole LV lead. In one example, referred to herein as QuickStim, cardiac pacing configurations are optimized based on an assessment of hemodynamic benefit and device longevity. In another example, referred to herein as QuickSense, cardiac sensing configurations are optimized based on sensing profiles input by a clinician. Various virtual sensing channels are also described that provide for the multiplexing or gating of sensed signals. Anisotropic oversampling is also described.

    摘要翻译： 提供技术用于使用多极LV引线配备用于多位点左心室（MSLV）起搏的可植入心脏刺激装置。 在一个例子中，本文称为QuickStim，基于对血液动力学益处和器械寿命的评估来优化心脏起搏配置。 在另一个例子中，本文称为QuickSense，基于由临床医生输入的感测曲线来优化心脏感测配置。 还描述了各种虚拟感测通道，其提供感测信号的复用或门控。 还描述了各向异性过采样。

    Monitoring heart disease using implantable sensors and slopes determined therefrom
    9.
    发明授权
    Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
    使用由其确定的可植入传感器和斜坡来监测心脏病

    公开(公告)号：US08170664B1

    公开(公告)日：2012-05-01

    申请号：US11931165

    申请日：2007-10-31

    申请人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    发明人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    IPC分类号： A61N1/37 ,  A61N1/08

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

    摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.

    摘要翻译： 本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。 确定斜率，其中斜率表示在一段时间内生理特性的变化。 基于斜率的大小来监测心脏病。 在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。 根据斜率的变化监测患者心脏病变化。