公开(公告)号：US08731665B1

公开(公告)日：2014-05-20

申请号：US11923286

申请日：2007-10-24

Applicant: Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

Inventor： Xiaoyi Min ,  Laleh Jalali ,  Steve Koh ,  Gene A. Bornzin ,  Euljoon Park

IPC: A61N1/00

CPC classification number: A61N1/365 ,  A61N1/36535

Abstract: Systems and methods are provided for detecting the orientation and/or movement of a patient having an implantable cardiac stimulation device and evaluating whether a change in the patient's cardiac activity can be at least in part due to a change in the patient's orientation. In one particular embodiment, signals from an orientation sensor and/or a pressure sensor are evaluated to determine static positional orientation of the patient and determine based on the static orientation whether the patient's cardiac activity is abnormal.

Abstract translation: 提供了用于检测具有可植入心脏刺激装置的患者的取向和/或运动的系统和方法，并且评估患者的心脏活动的变化是否可以至少部分地由于患者取向的改变而变化。 在一个特定实施例中，评估来自定向传感器和/或压力传感器的信号以确定患者的静态位置取向，并且基于静态取向来确定患者的心脏活动是否异常。

公开(公告)号：US08175707B1

公开(公告)日：2012-05-08

申请号：US11951928

申请日：2007-12-06

Applicant: Connie Wright ,  Xiaoyi Min ,  Euljoon Park ,  Scott Simon

Inventor： Connie Wright ,  Xiaoyi Min ,  Euljoon Park ,  Scott Simon

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/3682 ,  A61N1/3684

Abstract: An exemplary method includes delivering a cardiac resynchronization therapy using an atrio-ventricular delay and an interventricular delay, monitoring patient activity, optimizing the atrio-ventricular delay and the interventricular delay for a plurality of patient activity states to generate a plurality of optimal atrio-ventricular delays and a plurality of optimal interventricular delays, storing the optimal atrio-ventricular delays and the optimal interventricular delays in association with corresponding patient activity states, detecting a change in patient activity, adjusting an atrial pacing rate in response to the detected change in patient activity based at least in part on a heart failure status and setting the atrio-ventricular delay and the interventricular delay, in response to the detected change in patient activity, using a stored optimal atrio-ventricular delay that corresponds to the patient activity and a stored optimal interventricular delay that corresponds to the patient activity. Other exemplary technologies are also disclosed.

Abstract translation: 示例性方法包括使用心室延迟和心室间延迟来递送心脏再同步治疗，监测患者活动，优化多个患者活动状态的心房延迟和室间延迟以产生多个最佳心房室 延迟和多个最佳心室间延迟，存储与相应的患者活动状态相关联的最佳心室延迟和最佳心室延迟，检测患者活动的变化，响应于检测到的患者活动变化来调整心房起搏速率 至少部分地基于心力衰竭状态，并且响应于检测到的患者活动的变化来设置心室延迟和室间延迟，使用存储的对应于患者活动的最佳心室延迟和存储的最佳 室间延迟对应于pa 活跃。 还公开了其它示例性技术。

公开(公告)号：US07844333B1

公开(公告)日：2010-11-30

申请号：US11736155

申请日：2007-04-17

Applicant: Steve Koh ,  Euljoon Park ,  Eric Falkenberg

Inventor： Steve Koh ,  Euljoon Park ,  Eric Falkenberg

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61B5/0452 ,  A61N1/365

Abstract: Embodiments include methods and devices for detecting ischemia in a patient and treating the ischemia with a pacing therapy that increases cardiac efficiency, output, or both, without substantially increasing myocardial oxygen consumption. Such therapy may also be used to mitigate the adverse effects of decreased blood flow to the ischemic tissue by increasing the blood flow an oxygenation thereto.

Abstract translation: 实施方案包括用于检测患者局部缺血的方法和装置，并且通过起搏治疗来治疗缺血，其提高心脏效率，输出或两者，而不显着增加心肌耗氧量。 这种治疗也可用于通过增加血流对其的氧合来减轻血液流向缺血组织的不利影响。

公开(公告)号：US20100042173A1

公开(公告)日：2010-02-18

申请号：US12603829

申请日：2009-10-22

Applicant: Taraneh Ghaffari Farazi ,  Euljoon Park

Inventor： Taraneh Ghaffari Farazi ,  Euljoon Park

IPC: A61N1/368 ,  A61N1/08 ,  A61N1/365

CPC classification number: A61N1/368 ,  A61N1/3627 ,  A61N1/3684 ,  A61N1/3688

Abstract: Techniques are provided for evaluating and optimizing the contribution of particular heart chambers to pacing efficacy. Briefly, a pacemaker temporarily alters the mode with which pacing therapy is delivered so as to selectively alter the heart chambers that are paced. The pacemaker detects any transient changes in pacing efficacy following the alteration in pacing mode. The pacemaker then assesses the contribution of particular heart chambers to pacing efficacy based on the alteration in the pacing mode and on any transient changes in the pacing efficacy. Additionally, techniques are provided herein for automatically adjusting pacing parameters to optimize the contribution of particular chambers to pacing efficacy.

Abstract translation: 提供技术来评估和优化特定心室对起搏功效的贡献。 简而言之，起搏器暂时改变了起搏治疗的方式，以便选择性地改变起搏的心室。 心脏起搏器检测起搏模式改变后起搏功效的任何瞬时变化。 起搏器然后根据起搏模式的改变以及起搏功效的任何短暂变化来评估特定心室对起搏功效的贡献。 此外，本文提供了用于自动调整起搏参数以优化特定腔室对起搏功效的贡献的技术。

公开(公告)号：US07620448B1

公开(公告)日：2009-11-17

申请号：US11421915

申请日：2006-06-02

Applicant: Taraneh Ghaffari Farazi ,  Euljoon Park

Inventor： Taraneh Ghaffari Farazi ,  Euljoon Park

IPC: A61B5/04

CPC classification number: A61B5/0452 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/0422 ,  A61B5/0535 ,  A61B5/1107 ,  A61B5/1459 ,  A61B5/6852 ,  A61B5/7264 ,  A61B7/023 ,  A61B2562/0219 ,  A61N1/3622 ,  A61N1/36521 ,  A61N1/37258 ,  A61N1/3962

Abstract: Embodiments of the present invention relate to implantable systems, and methods for use therewith, for monitoring myocardial mechanical stability based on a signal that is indicative of mechanical functioning of a patient's heart for a plurality of consecutive beats. Certain embodiments use time domain techniques, while other embodiments use frequency domain techniques, to monitor myocardial mechanical stability. In certain embodiments the patient's heart is paced using a patterned pacing sequence that repeats every N beats. In other embodiments, the patient's heart need not be paced. This abstract is not intended to be a complete description of, or limit the scope of, the invention.

Abstract translation: 本发明的实施例涉及可植入系统及其使用的方法，用于基于指示患者心脏对于多个连续节拍的机械功能的信号来监测心肌机械稳定性。 某些实施例使用时域技术，而其他实施例使用频域技术来监测心肌机械稳定性。 在某些实施例中，使用重复每N次跳动的图案化起搏序列来对患者的心脏进行起搏。 在其他实施例中，患者的心脏不需要起搏。 本摘要不是对本发明的完整描述或限制本发明的范围。

公开(公告)号：US20090270936A1

公开(公告)日：2009-10-29

申请号：US12111876

申请日：2008-04-29

Applicant: Michael E. Benser ,  Euljoon Park

Inventor： Michael E. Benser ,  Euljoon Park

IPC: A61N1/36

CPC classification number: A61N1/3622 ,  A61N1/3624 ,  A61N1/3688

Abstract: A method and system are provided for providing coordinated ventricular overdrive and triggered pacing through an implantable system. A lead senses signals from a heart to obtain sensed signals representative of tachycardia occurring in at least one chamber of the heart. The lead includes an electrode. A control module detects tachycardia in at least one chamber of the heart and based thereon, initiates an overdrive pacing mode and a triggered pacing mode. The control module controls delivery of overdrive pacing pulses through the electrode to a first chamber of the heart in accordance with the overdrive pacing mode. The control module controls delivery of a triggered pacing pulse through the electrode to the first chamber of the heart in accordance with the triggered pacing mode. The triggered pacing pulse is temporally interspersed with the overdrive pacing pulses. The triggered pacing pulse may be delivered at a time that is independent of, and unrelated to, the timing of the overdrive pacing pulses.

Abstract translation: 提供了一种方法和系统，用于通过可植入系统提供协调的心室过度驱动和触发起搏。 引线感测来自心脏的信号以获得代表在心脏的至少一个腔室中发生的心动过速的感测信号。 引线包括电极。 控制模块在心脏的至少一个室中检测心动过速，并且基于此，启动过速起搏模式和触发的起搏模式。 控制模块根据超速起搏模式控制过驱动起搏脉冲通过电极传递到心脏的第一腔室。 控制模块根据触发的起搏模式控制触发的起搏脉冲通过电极传递到心脏的第一腔室。 触发起搏脉冲在时间上散布着超速起搏脉冲。 触发的起搏脉冲可以在与过速起搏脉冲的定时无关并且不相关的时间被传送。

公开(公告)号：US07596410B1

公开(公告)日：2009-09-29

申请号：US11413772

申请日：2006-04-28

Applicant: Mark W. Kroll ,  Michael Benser ,  Euljoon Park

Inventor： Mark W. Kroll ,  Michael Benser ,  Euljoon Park

IPC: A61N1/368

CPC classification number: A61N1/3962 ,  A61N1/0563 ,  A61N1/36071 ,  A61N1/3622

Abstract: An implantable system applies tiered antitachycardia pacing (ATP) that may be combined with pre-pulsing therapy in order to reduce pain. In one implementation, an exemplary system applies a progression of increasingly potent pacing vectors, progressing in an initial tier from small electrodes inside the heart to later tiers that increasingly use a large electrode surface outside the heart. In the latter tiers, a pre-pulse may be added prior to each ATP pulse to reduce the sensation of pain.

Abstract translation: 植入式系统应用分层抗心动过速起搏（ATP），可与预脉冲治疗相结合，以减轻疼痛。 在一个实施方案中，示例性系统应用越来越有效的起搏向量的进展，在初始层级内从心脏内的小电极进行到越来越多地使用心脏外的大电极表面的后续层级。 在后一级，可以在每个ATP脉冲之前加入预脉冲以减少疼痛的感觉。

公开(公告)号：US07460909B1

公开(公告)日：2008-12-02

申请号：US11205694

申请日：2005-08-16

Applicant: Steve Koh ,  Euljoon Park

Inventor： Steve Koh ,  Euljoon Park

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/3622 ,  A61N1/36521 ,  A61N1/3655 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36585 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/3925 ,  A61N1/3962

Abstract: An exemplary method includes providing a filling pressure parameter, providing a perfusion parameter, determining a hemodynamic profile based at least in part on the filling pressure parameter and the perfusion parameter and adjusting a stimulation parameter of an implantable cardiac therapy device based at least in part on the hemodynamic profile. Other exemplary methods, devices, systems, etc., are also disclosed.

Abstract translation: 示例性方法包括提供填充压力参数，提供灌注参数，至少部分地基于填充压力参数和灌注参数确定血液动力学分布，并且至少部分地基于至少部分地调节可植入心脏治疗装置的刺激参数 血流动力学特征。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US07430447B2

公开(公告)日：2008-09-30

申请号：US11149058

申请日：2005-06-06

Applicant: Xiaoyi Min ,  Euljoon Park ,  Malin Öhlander

Inventor： Xiaoyi Min ,  Euljoon Park ,  Malin Öhlander

IPC: A61N1/00

CPC classification number: A61B5/0535 ,  A61B5/0402 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61N1/3601 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/371

Abstract: An exemplary method includes acquiring impedance values over one or more respiratory cycles, determining an impedance span based on the impedance values and, based at least in part on the impedance span, determining cardiac condition or respiratory condition. Another exemplary method includes acquiring IEGMs over one or more respiratory cycles, determining evoked response measure values based on the IEGMs, determining an evoked response span based on the evoked response measure values and, based at least in part on the evoked response span, determining cardiac condition or respiratory condition. Other exemplary methods, devices, systems, etc., are also disclosed.

Abstract translation: 示例性方法包括：通过一个或多个呼吸周期获取阻抗值，基于阻抗值确定阻抗跨度，并且至少部分地基于阻抗跨度，确定心脏状况或呼吸状况。 另一示例性方法包括通过一个或多个呼吸周期获取IEGM，基于IEGM确定诱发的应答测量值，基于诱发的响应测量值确定诱发的应答跨度，并且至少部分地基于诱发的响应跨度，确定心脏 病情或呼吸状况。 还公开了其它示例性方法，装置，系统等。

公开(公告)号：US07371220B1

公开(公告)日：2008-05-13

申请号：US10883857

申请日：2004-06-30

Applicant: Steve Koh ,  Euljoon Park ,  Michael Benser

Inventor： Steve Koh ,  Euljoon Park ,  Michael Benser

IPC: A61B5/08

CPC classification number: A61B5/0809 ,  A61B5/4519 ,  A61B5/4818 ,  A61B5/7239

Abstract: Techniques are provided for detecting the onset of an episode of apnea/hypopnea substantially in real-time. A moving threshold is generated based on recent respiration cycles and differences are accumulated between amplitudes of new respiration cycles and the moving threshold. Apnea/hypopnea is then detected based upon a comparison of the accumulated differences against a fixed threshold. The technique exploits the fact that many episodes of hypopnea begin with a sharp drop in respiration and many episodes of apnea are preceded by a sharp drop in respiration. By accumulating differences between new respiration amplitudes and a short term moving average, any sharp drop in respiration is thereby promptly detected. In many cases, by the time the amplitudes of individual respiration cycles drop to levels directly indicative of apnea/hypopnea, the episode of apnea/hypopnea will have already been detected based upon the sudden sharp drop in respiration amplitude and therapy will have already been initiated.

Abstract translation: 提供了用于基本上实时检测呼吸暂停/呼吸不足发作的技术。 基于最近的呼吸循环产生移动阈值，并且在新呼吸循环的振幅和移动阈值之间累积差异。 然后基于累积差异与固定阈值的比较来检测呼吸暂停/呼吸不足。 该技术利用了许多次呼吸不畅的情况，呼吸急剧下降，许多呼吸暂停发作前呼吸急剧下降。 通过累积新的呼吸振幅和短期移动平均值之间的差异，因此迅速检测到呼吸中的任何急剧下降。 在许多情况下，当个别呼吸周期的振幅下降到直接指示呼吸暂停/呼吸不全的水平时，呼吸暂停/呼吸不足的发作将基于呼吸振幅的突然急剧下降而被检测到，并且已经开始治疗 。