公开(公告)号：US20240325529A1

公开(公告)日：2024-10-03

申请号：US18573750

申请日：2022-06-22

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Daisuke AKAZAWA

IPC: A61K39/395 ,  A61K31/282 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00

CPC classification number: A61K39/3955 ,  A61K31/282 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00

Abstract: A medicament characterized by comprising: an antibody or a fragment thereof having an immunological reactivity with CAPRIN-1 protein; a pyrimidine-based drug; a platinum formulation; and an angiogenesis inhibitor together or separately in combination is useful as a medicament for treatment and/or prevention of a cancer of a cancer patient having a medical history of another treatment of the cancer.

公开(公告)号：US20210188998A1

公开(公告)日：2021-06-24

申请号：US17177396

申请日：2021-02-17

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Takayoshi IDO ,  Takanori SAITO ,  Shinichi KOBAYASHI

IPC: C07K16/30 ,  A61K39/395

Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

公开(公告)号：US20190091315A1

公开(公告)日：2019-03-28

申请号：US16088682

申请日：2017-03-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: A61K39/00 ,  A61P35/00

Abstract: The present application relates to a novel immunity-inducing agent for treatment and/or prevention of cancer. Specifically, the present application provides an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from polypeptides derived from MCEMP1 and modified forms thereof, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo, and a method for inducing immunity, comprising administering the immunity-inducing agent to a subject.

公开(公告)号：US20190106505A1

公开(公告)日：2019-04-11

申请号：US16088502

申请日：2017-03-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Takayuki FUJITA ,  Fumiyoshi OKANO

IPC: C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: An object of the present invention is to identify cancer antigen proteins specifically expressed on the surface of cancer cells and to provide a use of antibodies targeting such proteins as therapeutic and/or preventive agents for cancer. The present invention relates to, for example, a pharmaceutical composition for treatment and/or prevention of a cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with an MCEMP1 protein having an amino acid sequence shown in any one of the even numbered SEQ ID NOS: 2 to 8 or an amino acid sequence having 80% or more sequence identity with the amino acid sequence, or with a fragment of the MCEMP1 protein comprising 7 or more consecutive amino acids.

公开(公告)号：US20180312603A1

公开(公告)日：2018-11-01

申请号：US15971647

申请日：2018-05-04

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Takayoshi IDO ,  Takanori SAITO ,  Shinichi KOBAYASHI

IPC: C07K16/30 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/3015 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3053 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734

Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.

公开(公告)号：US20180200356A1

公开(公告)日：2018-07-19

申请号：US15743869

申请日：2016-08-05

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

IPC: A61K39/00 ,  C07K14/47 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K35/15 ,  A61K35/17 ,  A61K35/76 ,  A61K39/00 ,  A61K39/39 ,  A61K45/00 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/572 ,  A61P35/00 ,  C07K14/47 ,  C07K14/4702 ,  C12N5/10 ,  C12N15/09

Abstract: An object of the present invention is to discover a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer. The immune inducer containing as an active ingredient: (a) a polypeptide consisting of any one of the amino acid sequences represented by SEQ ID NOs: 35 to 67; or (b) a polypeptide comprising one to several amino acid deletions, substitutions and/or additions in the amino acid sequence of the polypeptide (a); is useful as an agent for treating or preventing cancer, etc.

公开(公告)号：US20230190899A1

公开(公告)日：2023-06-22

申请号：US17972055

申请日：2022-10-24

Applicant: TORAY INDUSTRIES, INC.

Inventor： Akira KURIHARA ,  Fumiyoshi OKANO

IPC: A61K39/00 ,  A61K45/00 ,  A61K48/00 ,  C07K14/47 ,  A61K39/39 ,  C12N5/10 ,  C12N15/09 ,  A61K35/15 ,  A61K35/76 ,  A61K35/17 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K45/00 ,  A61K48/00 ,  C07K14/47 ,  A61K39/00 ,  A61K39/39 ,  C12N5/10 ,  C12N15/09 ,  A61K35/15 ,  A61K35/76 ,  A61K35/17 ,  A61P35/00 ,  C07K14/4702 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/572

Abstract: An object of the present invention is to discover a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer. The immune inducer containing as an active ingredient: (a) a polypeptide consisting of any one of the amino acid sequences represented by SEQ ID NOs: 35 to 67; or (b) a polypeptide comprising one to several amino acid deletions, substitutions and/or additions in the amino acid sequence of the polypeptide (a); is useful as an agent for treating or preventing cancer, etc.

公开(公告)号：US20230165957A1

公开(公告)日：2023-06-01

申请号：US17910532

申请日：2021-03-11

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Daisuke AKAZAWA

IPC: A61K39/395 ,  A61P35/04 ,  A61K33/243 ,  A61K31/7068

CPC classification number: A61K39/3955 ,  A61P35/04 ,  A61K33/243 ,  A61K31/7068

Abstract: An object of the present invention is to provide a medicament for treatment and/or prevention of cancer. The present invention provides a medicament for treatment and/or prevention of cancer in a cancer patient with a previous history of another cancer treatment, comprising an antibody or a fragment thereof having an immunological reactivity with CAPRIN-1 protein, and a pyrimidine-based drug and cisplatin together or separately in combination.

公开(公告)号：US20200054762A1

公开(公告)日：2020-02-20

申请号：US16344689

申请日：2017-10-27

Applicant: TORAY INDUSTRIES, INC.

Inventor： Fumiyoshi OKANO ,  Takanori SAITO

IPC: A61K47/68 ,  A61K39/395 ,  A61P35/02 ,  A61K31/4745

Abstract: The present invention provides a conjugate of an antibody or a fragment thereof linked to an immune activator, wherein the antibody or the fragment thereof has immunological reactivity with a CAPRIN-1 protein, and a pharmaceutical composition comprising the conjugate as an active ingredient for treatment and/or prevention of a cancer which is superior in antitumor activity to conventional antibodies or conjugates of an antibody and an immune activator.

公开(公告)号：US20170035869A1

公开(公告)日：2017-02-09

申请号：US15331518

申请日：2016-10-21

Applicant: TORAY INDUSTRIES, INC.

Inventor： Masaki ISHIBASHI ,  Fumiyoshi OKANO

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K38/208 ,  A61K38/212 ,  A61K38/215 ,  A61K2039/53 ,  A61K2300/00

Abstract: An immunity-inducing agent comprising as an effective ingredient a specific polypeptide is disclosed. These polypeptides were isolated, by the SEREX method using a cDNA library derived from canine testis and serum from a cancer-bearing dog, as a polypeptide which binds to an antibody existing specifically in serum derived from a cancer-bearing living body. The polypeptides can induce immunity in a living body and cause regression of a tumor in a cancer-bearing living body. Therefore, these polypeptides are especially effective as a therapeutic and/or prophylactic agent for a cancer(s).