知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.021 秒)

    METHOD FOR PRODUCING NEURAL STEM CELLS USING SYNTHETIC PEPTIDE
    3.
    发明申请
    METHOD FOR PRODUCING NEURAL STEM CELLS USING SYNTHETIC PEPTIDE 有权

    公开(公告)号：US20170088817A1

    公开(公告)日：2017-03-30

    申请号：US15279890

    申请日：2016-09-29

    申请人： TOAGOSEI CO. LTD. ,  KEIO UNIVERSITY

    发明人： Nahoko BAILEYKOBAYASHI ,  Kenichi TANAKA ,  Tetsuhiko YOSHIDA ,  Jun KUDO

    IPC分类号： C12N5/0797

    摘要： The composition for producing neural stem cells provided by the present invention contains an artificially synthesized synthetic peptide having a neural stem cell-inducing peptide sequence that induces neural stem cells from fibroblasts, and one or two or more pharmaceutically acceptable carriers. The neural stem cell-inducing peptide sequence is any of (i) an amino acid sequence constituting a signal peptide of any protein belonging to the amyloid precursor protein (APP) family, (ii) a partial amino acid sequence of the amino acid sequence of (i), and (iii) a modified amino acid sequence of the amino acid sequence of (i) or (ii).

    SYNTHETIC PEPTIDE THAT INCREASES RADIOSENSITIVITY OF TUMOR CELLS AND USE OF SAME
    6.
    发明申请
    SYNTHETIC PEPTIDE THAT INCREASES RADIOSENSITIVITY OF TUMOR CELLS AND USE OF SAME 审中-公开
    增加肿瘤细胞的放射敏感性和使用它们的合成肽

    公开(公告)号：US20160346346A1

    公开(公告)日：2016-12-01

    申请号：US15164073

    申请日：2016-05-25

    申请人： TOAGOSEI CO., LTD.

    发明人： Nahoko BAILEYKOBAYASHI ,  Noriko USAMI ,  Tetsuhiko YOSHIDA

    IPC分类号： A61K38/08 ,  A61K41/00 ,  A61N5/10 ,  A61K38/10

    CPC分类号： A61K38/08 ,  A61K9/1623 ,  A61K38/10 ,  A61K41/0038 ,  A61N5/10 ,  A61N2005/1087 ,  A61N2005/1098

    摘要： Provided are a synthetic peptide that increases the radiosensitivity of tumor cells and a pharmaceutical composition containing that synthetic peptide.The peptide provided by the present invention is a synthetic peptide having a radiosensitizing peptide sequence including the following amino acid sequence: CX2X3KX5X6X7X8C (wherein, X2 represents K or R, X3 represents S or A, X5 represents S or A, X6 represents R or G, X7 represents R or D and X8 represents S or P); or, a modified amino acid sequence in which one, two or three amino acid residues are substituted, deleted and/or added in that amino acid sequence. In addition, the pharmaceutical composition provided by the present invention is a composition used to increase the sensitivity of tumor cells to radiation in tumor radiation therapy, and contains the synthetic peptide described above.

    CELL GROWTH-PROMOTING PEPTIDE AND USE THEREOF
    7.
    发明申请
    CELL GROWTH-PROMOTING PEPTIDE AND USE THEREOF 有权
    细胞生长促进肽及其用途

    公开(公告)号：US20140335613A1

    公开(公告)日：2014-11-13

    申请号：US14341177

    申请日：2014-07-25

    申请人： TOAGOSEI CO., LTD.

    发明人： Tetsuhiko YOSHIDA ,  Nahoko KOBAYASHI

    IPC分类号： C12N5/074

    CPC分类号： C12N5/0663 ,  C07K14/4711 ,  C07K2319/74 ,  C12N2501/998

    摘要： The pharmaceutical composition provided by the present invention comprises at least one pharmaceutically acceptable carrier, and an active ingredient including an artificially synthesized peptide comprises: (A) an amino acid sequence constituting a cell-penetrating peptide and (B) an amino acid sequence constituting the signal peptide in amyloid precursor protein (APP) or an N-terminal partial amino acid sequence or C-terminal partial amino acid sequence from the amino acid sequence constituting that signal peptide.

    摘要翻译： 由本发明提供的药物组合物包含至少一种药学上可接受的载体和包含人造合成肽的活性成分，包括：（A）构成细胞穿透肽的氨基酸序列和（B）构成细胞穿透肽的氨基酸序列 来自构成该信号肽的氨基酸序列的淀粉样蛋白前体蛋白（APP）或N末端部分氨基酸序列或C末端部分氨基酸序列中的信号肽。

    CARRIER PEPTIDE FRAGMENT AND USE THEREOF
    8.
    发明申请
    CARRIER PEPTIDE FRAGMENT AND USE THEREOF 审中-公开
    载体蛋白片段及其用途

    公开(公告)号：US20130323776A1

    公开(公告)日：2013-12-05

    申请号：US13936782

    申请日：2013-07-08

    申请人： Toagosei Co. Ltd.

    发明人： Tetsuhiko YOSHIDA ,  Nahoko KOBAYASHI ,  Mikio NIWA ,  Kenichi TANAKA

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5005 ,  A61K31/7088 ,  A61K47/64 ,  A61K47/645 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001 ,  C07K2319/00

    摘要： A method for transferring a foreign substance includes: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including any amino acid sequence selected from SEQ ID NOS: 1-6, or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence of the selected sequence identification number, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.

    摘要翻译： 用于转移异物的方法包括：制备包含含有选自SEQ ID NO：1-6的任何氨基酸序列的载体肽片段的外源物质或通过取代，缺失形成的氨基酸序列的构建体， 和/或所选序列识别号的氨基酸序列中1,2或3个氨基酸残基的添加（插入），以及与N末端和/或C末端连接的目标异构体 载体肽片段; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。