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    PERCUTANEOUS MEDICAL DEVICE DELIVERY SYSTEM
    1.
    发明申请
    PERCUTANEOUS MEDICAL DEVICE DELIVERY SYSTEM 有权

    公开(公告)号：US20220296879A1

    公开(公告)日：2022-09-22

    申请号：US17612374

    申请日：2020-05-18

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Arash Kheradvar ,  Gregory S. Kelley

    IPC分类号： A61M60/865 ,  A61M60/191 ,  A61M60/289 ,  A61M60/47 ,  A61M60/861

    摘要： A medical device delivery system including a delivery sheath that includes an internal lumen, and a plurality of delivery arms contained within the internal lumen of the delivery sheath and extending along a longitudinal axis of the internal lumen of the delivery sheath, wherein distal ends of the delivery arms include fasteners configured to engage with a basal structure of a medical device and a apical structure of the medical device, wherein the delivery arms are attached to delivery arm controls that are configured to advance the delivery arms and the medical device attached thereto out from a distal end of the delivery sheath, and removable release wires or release lines configured to engage with the fasteners to hold the basal structure and the apical structure in place at the fasteners. Also disclosed are methods of delivering a medical device to a subject including inserting a distal end of the medical device delivery system through an incision in the skin of subject, and deploying a medical device engaged with the delivery arms of the medical delivery system to within the body of the subject.

    FULLY AUTOMATED FOUR-CHAMBER SEGMENTATION OF ECHOCARDIOGRAMS
    2.
    发明申请
    FULLY AUTOMATED FOUR-CHAMBER SEGMENTATION OF ECHOCARDIOGRAMS 有权

    公开(公告)号：US20210012885A1

    公开(公告)日：2021-01-14

    申请号：US16926517

    申请日：2020-07-10

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Arghavan Arafati ,  Hamid Jafarkhani ,  Arash Kheradvar

    IPC分类号： G16H30/40 ,  G06N3/08

    摘要： Devices, systems and methods related to techniques for performing four-chamber segmentation of echocardiograms are disclosed. In one example aspect, a method for generating segmented image data based on an input echocardiogram includes receiving an input echocardiogram that includes information associated with four chambers of a heart, performing segmentation on the information associated with the four chambers using an adversarial model that comprises a first artificial neural network with multiple layers, and combining data from selected layers of the first artificial neural network to generate an output image that includes the segmented four chambers of the heart.

    MITOCHONDRIAL TRANSPLANTATION TO ALTER ENERGY METABOLISM
    3.
    发明申请
    MITOCHONDRIAL TRANSPLANTATION TO ALTER ENERGY METABOLISM 审中-公开

    公开(公告)号：US20200181578A1

    公开(公告)日：2020-06-11

    申请号：US16794115

    申请日：2020-02-18

    申请人： The Regents of The University of California

    发明人： Arash Kheradvar ,  Paria Ali Pour

    IPC分类号： C12N5/077 ,  A61K35/12 ,  A61K35/34

    摘要： A method of altering energy metabolism in a recipient cell including: identifying the recipient cell as being in need of altering its oxidative phosphorylation status, obtaining exogenous mitochondria, and introducing into the recipient cell the exogenously obtained mitochondria, wherein the exogenously obtained mitochondria functions in the recipient cell to increase or decrease oxidative phosphorylation and/or glycolysis. Also disclosed are isolated cells that include an exogenous mitochondria, wherein the cell demonstrates increased energy metabolism compared to a control cell of the same type but wherein the control cell lacks exogenously added mitochondria. Also disclosed are methods of treating a subject suffering from ischemia or a mitochondrial dysfunction including administering one or more group of isolated cells including exogenous mitochondria as disclosed herein to the subject, wherein the one or more isolated cell including exogenous mitochondria improve symptoms of the ischemia or the mitochondrial dysfunction.

    AUTOMATED SEGMENTATION OF ORGAN CHAMBERS USING DEEP LEARNING METHODS FROM MEDICAL IMAGING
    7.
    发明申请
    AUTOMATED SEGMENTATION OF ORGAN CHAMBERS USING DEEP LEARNING METHODS FROM MEDICAL IMAGING 审中-公开

    公开(公告)号：US20170109881A1

    公开(公告)日：2017-04-20

    申请号：US15294207

    申请日：2016-10-14

    申请人： The Regents of the University of California

    发明人： Michael Rashidi Avendi ,  Hamid Jafarkhani ,  Arash Kheradvar

    IPC分类号： G06T7/00 ,  G06T3/00

    摘要： Systems and methods are disclosed for automatically segmenting a heart chamber from medical images of a patient. The system may include one or more hardware processors configured to: obtain image data including at least a representation of the patient's heart; obtain a region of interest from the image data; organize the region of interest into an input vector; apply the input vector through a trained graph; obtain an output vector representing a refined region of interest corresponding to the heart based on the application of the input vector through the trained graph; apply a deformable model on the obtained output vector representing the refined region of interest; and identify a segment of a heart chamber from the application of the deformable model on the obtained output vector.

    CALCIFIED POLYMERIC VALVE AND VESSELS FOR VALVE-IN-VALVE APPLICATIONS
    8.
    发明申请
    CALCIFIED POLYMERIC VALVE AND VESSELS FOR VALVE-IN-VALVE APPLICATIONS 审中-公开
    用于阀门应用的计算聚合物阀和容器

    公开(公告)号：US20170076637A1

    公开(公告)日：2017-03-16

    申请号：US15265593

    申请日：2016-09-14

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Arash Kheradvar

    IPC分类号： G09B23/32

    CPC分类号： G09B23/32 ,  G09B23/30

    摘要： Described is a group of polymeric calcific heart valves with different levels of calcification that can be used for research and development studies related to transcatheter heart valve technologies. Using a heart flow simulator, the valves' function was studied in aortic position in the presence or absence of an implanted transcatheter aortic valve (valve-in-valve). Through multiple experiments based on echocardiography, it was found that these calcific valves can suitably mimic the function of a native calcified stenotic aortic valve and can be used for valve-in-valve studies. Using this novel polymeric calcified valve provides a desired cost-saving solution for testing the performance of new TAVR systems in vitro and in vivo.

    摘要翻译： 描述了一组具有不同钙化水平的聚合钙化心脏瓣膜，可用于与经导管心脏瓣膜技术相关的研究和开发研究。 使用心脏流动模拟器，在存在或不存在植入的经导管主动脉瓣（瓣膜阀））的主动脉位置中研究了瓣膜的功能。 通过基于超声心动图的多次实验，发现这些钙化瓣膜可以适当地模拟天然钙化狭窄主动脉瓣的功能，并可用于瓣膜瓣膜研究。 使用这种新型聚合钙化阀为体外和体内新TAVR系统的性能测试提供了一个所需的节省成本的解决方案。