公开(公告)号：US20190060490A1

公开(公告)日：2019-02-28

申请号：US15771786

申请日：2016-10-27

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： WOJCIECH LESNIAK ,  SRIDHAR NIMMAGADDA ,  NIKITA OSKOLKOV ,  MICHAEL MCMAHON ,  XIAOLEI SONG ,  MARTIN G. POMPER

IPC: A61K49/12 ,  A61K49/16 ,  A61K51/06 ,  A61K51/04 ,  A61K49/10 ,  C08G73/02 ,  C08G83/00

Abstract: PAMAM dendrimer based CEST imaging agents, pharmaceutical compositions comprising the same and methods of uses thereof are disclosed.

公开(公告)号：US20160082132A1

公开(公告)日：2016-03-24

申请号：US14891531

申请日：2014-05-16

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： XING YANG ,  XIAOLEI SONG ,  SANGEETA RAY ,  MARTIN G. POMPER ,  MICHAEL T. MCMAHON

IPC: A61K49/10 ,  A61B6/00 ,  A61B6/03 ,  A61B5/055 ,  A61B5/00

CPC classification number: A61K49/10 ,  A61B5/055 ,  A61B5/4842 ,  A61B6/037 ,  A61B6/481 ,  G01R33/5601 ,  G01R33/5605

Abstract: Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI) or frequency labeled exchange (FLEX) imaging are disclosed. Beta-hydroxycarboxylate and beta-aminocarboxylate derivatives including salicylic acid, salicylates, salicylic acid prodrugs, N-alkyl/aryl/acyl/sulfonyl-anthranilic acid analogs, and any aromatic compound with OH/NH group ortho to the carboxylic acid group are disclosed. Such compounds can be used as general MRI organic contrast agents and produce significantly improved contrast in MR images detectable through CEST or FLEX.

Abstract translation: 公开了用于化学交换饱和转移（CEST）的磁共振成像（MRI）或频率标记交换（FLEX）成像的组合物和方法。 公开了β-羟基羧酸盐和β-氨基羧酸盐衍生物，包括水杨酸，水杨酸盐，水杨酸前药，N-烷基/芳基/酰基/磺酰基 - 邻氨基苯甲酸类似物和任何与羧酸基团邻位的OH / NH基团的芳族化合物。 这种化合物可以用作一般的MRI有机造影剂，并且通过CEST或FLEX可检测的MR图像产生显着改善的对比度。