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公开(公告)号：US10213488B2
公开(公告)日：2019-02-26
申请号：US15386626
申请日：2016-12-21
申请人： The Board of Trustees of the University of Arkansas , The Kitasato Institute , MONTEFIORE MEDICAL CENTER
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US20130337017A1
公开(公告)日：2013-12-19
申请号：US13898058
申请日：2013-05-20
IPC分类号： C12N9/64
CPC分类号： C07K14/635 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K35/28 , A61K38/164 , A61K38/29 , A61K38/4886 , A61K2800/86 , A61K2800/91 , A61Q7/00 , C07K2319/00 , C07K2319/50 , C07K2319/70 , C12N9/1088 , C12N9/50 , C12N9/52 , C12N9/6489 , C12Y205/01018 , C12Y304/24003 , C12Y304/24007
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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公开(公告)号：US11624060B2
公开(公告)日：2023-04-11
申请号：US16485290
申请日：2018-02-09
发明人： Joshua Sakon , Jeffrey Roeser , Ryan Bauer , Katarzyna Janowska , Keisuke Tanaka , Osamu Matsushita , Kentaro Uchida
IPC分类号： A61K38/18 , A61K38/16 , C07K14/50 , A61P19/08 , C12N9/52 , A61P19/00 , A61K8/64 , A61K8/66 , A61Q7/00 , C07K14/635
摘要： The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.
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公开(公告)号：US10442842B2
公开(公告)日：2019-10-15
申请号：US15448282
申请日：2017-03-02
发明人： Robert R. Beitle , Rudra Palash Mukherjee , Suresh K. Thallapuranam , Joshua Sakon , David S. McNabb
IPC分类号： C07K14/435 , B01D15/08
摘要： Photoluminescent proteins resistant to protein cleavage reagents are described herein. In being resistant to cleavage reagents, such photoluminesncent proteins can reduce the number of digestion or cleavage products, thereby simplifying quantification and purification of recombinant protein compositions. In some embodiments, a photoluminescent protein described herein comprises an amino acid sequence having an absence of internal methionine residues.
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公开(公告)号：US20190135890A1
公开(公告)日：2019-05-09
申请号：US16249540
申请日：2019-01-16
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , OCHSNER CLINIC FOUNDATION , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
IPC分类号： C07K14/635 , A61K9/00 , C12N9/10 , C12N9/64 , C12N9/50 , A61K35/28 , A61K38/16 , A61K8/64 , A61K8/66 , A61K38/48 , A61K38/29 , A61Q7/00 , C12N9/52
CPC分类号： C07K14/635 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K35/28 , A61K38/164 , A61K38/29 , A61K38/4886 , A61K2800/86 , A61K2800/91 , A61Q7/00 , C07K2319/00 , C07K2319/50 , C07K2319/70 , C12N9/1088 , C12N9/50 , C12N9/52 , C12N9/6489 , C12Y205/01018 , C12Y304/24003 , C12Y304/24007
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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公开(公告)号：US10202434B2
公开(公告)日：2019-02-12
申请号：US15387817
申请日：2016-12-22
IPC分类号： A61K38/29 , C07K14/635 , C12N9/52 , C12N9/64 , A61K8/64 , A61K8/66 , A61K38/48 , A61Q7/00 , C12N9/50 , A61K38/16 , A61K35/28 , A61K9/00 , C12N9/10
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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7.发明申请FUSION PROTEINS OF COLLAGEN-BINDING DOMAIN AND PARATHYROID HORMONE 有权胶原蛋白结合域和PARAMYROID HORMONE的融合蛋白公开(公告)号：US20150284701A1
公开(公告)日：2015-10-08
申请号：US14743629
申请日：2015-06-18
CPC分类号： C07K14/635 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K35/28 , A61K38/164 , A61K38/29 , A61K38/4886 , A61K2800/86 , A61K2800/91 , A61Q7/00 , C07K2319/00 , C07K2319/50 , C07K2319/70 , C12N9/1088 , C12N9/50 , C12N9/52 , C12N9/6489 , C12Y205/01018 , C12Y304/24003 , C12Y304/24007
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
摘要翻译： 提供了含有与胶原结合结构域偶联的甲状旁腺素（PTH）和甲状旁腺激素相关肽（PTHrP）的活性激动剂或拮抗剂片段的融合蛋白。 融合蛋白可用于促进骨生长，促进毛发生长，预防癌症转移到骨骼，促进骨髓干细胞移植免疫重建，促进骨髓干细胞的移动，用于自体干细胞移植 ，并治疗肾性骨营养不良。 还提供了包含与非肽肽PTH / PTHrP受体激动剂或拮抗剂连接的胶原结合多肽片段的药剂。
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公开(公告)号：US11279922B2
公开(公告)日：2022-03-22
申请号：US16283468
申请日：2019-02-22
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , The Kitasato Institute , MONTEFIORE MEDICAL CENTER , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
发明人： Tulasi Ponnapakkam , Sagaya Theresa Leena Philominathan , Joshua Sakon , Ranjitha Katikaneni , Takaki Koide , Osamu Matsushita , Robert C. Gensure , Nozomu Nishi
IPC分类号： A61K38/29 , A61K38/17 , A61K38/18 , A61K38/19 , A61K39/395 , C12N9/52 , A61K8/49 , A61K8/65 , A61Q7/00 , A61K47/64 , A61K8/64 , A61K8/66 , A61K38/30 , A61K39/44 , A61Q7/02 , A61K38/27 , C07K14/475 , C07K14/485 , C07K14/49 , C07K14/495 , C07K14/50 , C07K14/51 , C07K14/535 , C07K14/61 , C07K14/71 , C07K16/18 , A61K39/00 , A61K38/00
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
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公开(公告)号：US20190338010A1
公开(公告)日：2019-11-07
申请号：US16517988
申请日：2019-07-22
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , OCHSNER CLINIC FOUNDATION , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
IPC分类号： C07K14/635 , A61K9/00 , C12N9/10 , C12N9/64 , C12N9/50 , A61K35/28 , A61K38/16 , A61K8/64 , A61K8/66 , A61K38/48 , A61K38/29 , A61Q7/00 , C12N9/52
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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公开(公告)号：US20170253640A1
公开(公告)日：2017-09-07
申请号：US15448282
申请日：2017-03-02
发明人： Robert R. BEITLE , Rudra Palash Mukherjee , Suresh K. Thallapuranam , Joshua Sakon , David S. McNabb
IPC分类号： C07K14/435 , B01D15/08 , C07K1/16
CPC分类号： C07K14/43595 , B01D15/08
摘要： Photoluminescent proteins resistant to protein cleavage reagents are described herein. In being resistant to cleavage reagents, such photoluminesncent proteins can reduce the number of digestion or cleavage products, thereby simplifying quantification and purification of recombinant protein compositions. In some embodiments, a photoluminescent protein described herein comprises an amino acid sequence having an absence of internal methionine residues.
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