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公开(公告)号：US11286476B2
公开(公告)日：2022-03-29
申请号：US16339866
申请日：2017-09-28
发明人： Pascale Feldmann , Jeffrey David Fowler , Nema Devi Jhurry , Isabelle Maillet , Marta Omedes Pujol
摘要： Methods of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the cell composition a compound having the function of a protein—or amine—cross linking agent and/or an acid, and compositions comprising the cells comprising dsRNA, and protein cross linking agents and/or acids, as well as the use of the cross linking agents and/or acids in the method.
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公开(公告)号：US11130949B2
公开(公告)日：2021-09-28
申请号：US16339989
申请日：2017-09-19
摘要： The present invention provides for methods of delivering polynucleotides to subterranean plant pests. In particular, the present invention relates to methods of reducing the binding of a composition, comprising polynucleotide and a cationic polymer, to soil by substantially quenching positively charged residues with a quenching agent. The invention also comprises compositions comprising a cationic polymer, a polynucleotide and a quenching agent.
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公开(公告)号：US11013231B2
公开(公告)日：2021-05-25
申请号：US16263938
申请日：2019-01-31
发明人： Jeffrey David Fowler , Sejong Kim
摘要： Stabilized liquid cyclopropane compositions are provided which compromise flowable, non-aqueous dispersion concentrates comprising a) a continuous substantially water-immiscible liquid phase and b) a dispersed solid phase comprising cured polymer particles prepared from a polymerizable thermoset resin which particles contain at least one cylcopropene complex, optionally a non-porous particulate mineral, and optionally a non-cross-linkable mobile chemical distributed therein, and wherein the outside surfaces of the particles comprise a colloidal solid material. The compositions of the invention can be used directly or with dilution to combat pests or as plant growth regulators.
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公开(公告)号：US11503827B2
公开(公告)日：2022-11-22
申请号：US16436226
申请日：2019-06-10
发明人： Jeffrey David Fowler , Sejong Kim
摘要： Stabilized liquid agrochemical compositions are provided that comprise flowable, aqueous dispersion concentrates comprising a) a continuous aqueous liquid phase; b) at least one dispersed, solid phase comprising a dispersion of polymer particles having a mean particle size of at least one micron, wherein the outside surfaces of the particles comprise a colloidal solid material and wherein the particles have at least one agrochemically active ingredient distributed therein, optionally a non-porous particulate mineral that acts as a diffusion barrier to slow the release of the active ingredient, and optionally at least one non-cross-linkable mobile chemical such that the extraction of this chemical from the disperse phase renders it porous in a manner that allows the active ingredient to diffuse out. The colloidal solid is used to stabilize the polymerizable resin in an emulsion state during preparation. In one embodiment, the agrochemically active ingredient is a solid and is distributed within the dispersed solid phase or is a liquid and is distributed within the dispersed solid phase. The compositions of the invention can be used directly or with dilution to combat pests or as plant growth regulators.
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公开(公告)号：US10314304B2
公开(公告)日：2019-06-11
申请号：US16002684
申请日：2018-06-07
发明人： Jeffrey David Fowler , Sejong Kim
摘要： Stabilized liquid agrochemical compositions are provided that comprise flowable, aqueous dispersion concentrates comprising a) a continuous aqueous liquid phase; b) at least one dispersed, solid phase comprising a dispersion of polymer particles having a mean particle size of at least one micron, wherein the outside surfaces of the particles comprise a colloidal solid material and wherein the particles have at least one agrochemically active ingredient distributed therein, optionally a non-porous particulate mineral that acts as a diffusion barrier to slow the release of the active ingredient, and optionally at least one non-cross-linkable mobile chemical such that the extraction of this chemical from the disperse phase renders it porous in a manner that allows the active ingredient to diffuse out. The colloidal solid is used to stabilize the polymerizable resin in an emulsion state during preparation. In one embodiment, the agrochemically active ingredient is a solid and is distributed within the dispersed solid phase or is a liquid and is distributed within the dispersed solid phase. The compositions of the invention can be used directly or with dilution to combat pests or as plant growth regulators.
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公开(公告)号：US20180289015A1
公开(公告)日：2018-10-11
申请号：US15765941
申请日：2016-09-27
IPC分类号： A01N63/02 , C12N15/10 , C12N15/113 , C12N15/11
摘要： The present invention provides a method of substantially retaining or otherwise preserving the biological activity of a dsRNA, present in a cell lysate, to post-transcriptionally silence the expression of a gene in a target organism, comprising the step of adding to the lysate a compound having the function of a protein- or amine-cross linking agent. The invention also comprises compositions comprising the lysate comprising dsRNA, and protein cross linking agents, as well as the use of said agents in the method.
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公开(公告)号：US20140274720A1
公开(公告)日：2014-09-18
申请号：US14353947
申请日：2012-10-26
发明人： Sejong Kims , Jeffrey David Fowler
IPC分类号： A01N25/10
摘要： A dispersion comprising (a) a continuous liquid phase; and (b) a solid phase of epoxypolymer particles dispersed in the continuous liquid phase; where the polymer is formed from monomers that are insoluble in the continuous phase; a chemical agent is present within the polymer particles; and the dispersion is not a Pickering dispersion; and optionally the polymer molecules that form the polymer particles contain hydrophilic groups that hydrate on exposure to water in a manner that renders the particles permeable and that allows the chemical agent to diffuse out, and optionally at least one non-cross-linkable mobile chemical such that the extraction of this chemical from the dispersed phase renders it porous in a manner that allows the chemical agent to diffuse out.
摘要翻译： 一种分散体，包括（a）连续液相; 和（b）分散在连续液相中的环氧聚合物颗粒的固相; 其中聚合物由不溶于连续相的单体形成; 聚合物颗粒内存在化学试剂; 并且分散体不是皮克林分散体; 并且任选地，形成聚合物颗粒的聚合物分子含有亲水基团，其以暴露于水中的方式水合，使得颗粒可渗透并允许化学试剂扩散出来，以及任选地至少一种不可交联的移动化学品 从分散相中提取该化学物质使其以允许化学试剂扩散出去的方式多孔化。
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