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公开(公告)号：US07132399B2
公开(公告)日：2006-11-07
申请号：US10619992
申请日：2003-07-15
申请人： Steven Hefeneider , Robert Bennett
发明人： Steven Hefeneider , Robert Bennett
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , C07K16/28 , G01N2500/10 , G01N2800/382
摘要： The present invention relates to novel mammalian DNA-R proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian DNA-R proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian DNA-R gene. Also provided are recombinant expression constructs capable of expressing the mammalian DNA-R genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian catecholamine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian DNA-R proteins of the invention, and further characterizing the binding properties of such compounds in comparison with known DNA-R agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
摘要翻译： 本发明涉及新型哺乳动物DNA-R蛋白和编码这种蛋白质的基因。 本发明涉及哺乳动物DNA-R蛋白的分离和表征。 本发明特别提供了与哺乳动物DNA-R基因的大鼠和人类同系物相对应的mRNA的分离的互补DNA拷贝。 还提供了能够在转化的原核和真核细胞的培养物中表达本发明的哺乳动物DNA-R基因以及合成其中编码的哺乳动物儿茶酚胺受体蛋白质的转化细胞的这种培养物的重组表达构建体。 本发明还提供了在体外筛选能够结合本发明的哺乳动物DNA-R蛋白的方法，并且与已知的DNA-R激动剂和拮抗剂相比进一步表征了这些化合物的结合特性。 从而提供改进的药理学筛选方法。
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2.发明申请公开(公告)号：US20050239163A1
公开(公告)日：2005-10-27
申请号：US10619992
申请日：2003-07-15
申请人： Steven Hefeneider , Robert Bennett
发明人： Steven Hefeneider , Robert Bennett
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K48/00 , A61P11/00 , A61P29/00 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , C07H21/04 , C12N1/00
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , C07K16/28 , G01N2500/10 , G01N2800/382
摘要： The present invention relates to novel mammalian DNA-R proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian DNA-R proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian DNA-R gene. Also provided are recombinant expression constructs capable of expressing the mammalian DNA-R genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian catecholamine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian DNA-R proteins of the invention, and further characterizing the binding properties of such compounds in comparison with known DNA-R agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
摘要翻译： 本发明涉及新型哺乳动物DNA-R蛋白和编码这种蛋白质的基因。 本发明涉及哺乳动物DNA-R蛋白的分离和表征。 本发明特别提供了与哺乳动物DNA-R基因的大鼠和人类同系物相对应的mRNA的分离的互补DNA拷贝。 还提供了能够在转化的原核和真核细胞的培养物中表达本发明的哺乳动物DNA-R基因以及合成其中编码的哺乳动物儿茶酚胺受体蛋白质的转化细胞的这种培养物的重组表达构建体。 本发明还提供了在体外筛选能够结合本发明的哺乳动物DNA-R蛋白的方法，并且与已知的DNA-R激动剂和拮抗剂相比进一步表征了这些化合物的结合特性。 从而提供改进的药理学筛选方法。
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公开(公告)号：US20070129308A1
公开(公告)日：2007-06-07
申请号：US11656512
申请日：2007-01-23
申请人： Steven Hefeneider , Sharon McCoy
发明人： Steven Hefeneider , Sharon McCoy
IPC分类号： A61K38/10
CPC分类号： C07K19/00 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/005 , C12N2710/24122
摘要： Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject.
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公开(公告)号：US20060009391A1
公开(公告)日：2006-01-12
申请号：US11178316
申请日：2005-07-12
申请人： Steven Hefeneider , Sharon McCoy
发明人： Steven Hefeneider , Sharon McCoy
CPC分类号： C07K19/00 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/005 , C12N2710/24122
摘要： Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject.
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公开(公告)号：US06602707B2
公开(公告)日：2003-08-05
申请号：US09921099
申请日：2001-08-01
IPC分类号： C07H2104
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00 , C07K16/28 , G01N2500/10 , G01N2800/382
摘要： The present invention relates to novel mammalian DNA-R proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian DNA-R proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian DNA-R gene. Also provided are recombinant expression constructs capable of expressing the mammalian DNA-R genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian catecholamine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian DNA-R proteins of the invention, and further characterizing the binding properties of such compounds in comparison with known DNA-R agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
摘要翻译： 本发明涉及新型哺乳动物DNA-R蛋白和编码这种蛋白质的基因。 本发明涉及哺乳动物DNA-R蛋白的分离和表征。 本发明特别提供了与哺乳动物DNA-R基因的大鼠和人类同系物相对应的mRNA的分离的互补DNA拷贝。 还提供了能够在转化的原核和真核细胞的培养物中表达本发明的哺乳动物DNA-R基因以及合成其中编码的哺乳动物儿茶酚胺受体蛋白质的转化细胞的这种培养物的重组表达构建体。 本发明还提供了在体外筛选能够结合本发明的哺乳动物DNA-R蛋白的方法，并且与已知的DNA-R激动剂和拮抗剂相比进一步表征了这些化合物的结合特性。 从而提供改进的药理学筛选方法。
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