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公开(公告)号：US5710164A
公开(公告)日：1998-01-20
申请号：US470603
申请日：1995-06-06
IPC分类号： C07D319/18 , A61K31/335 , A61K31/357 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/47 , A61P9/10 , C07D213/57 , C07D215/12 , C07D401/06 , C07D405/06 , C07D471/04 , C07D213/04
CPC分类号： C07D401/06 , C07D213/57 , C07D405/06 , C07D471/04
摘要： Disclosed herein are compounds of the formula: ##STR1## where Ar.sub.1 and Ar.sub.2 are, independently, pyridinyl, quinolinyl, 1,4-benzodioxanyl, dihydro-1,4-benzodioxanyl, pyrrolyl, azaindolyl or carbazolyl, or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.
摘要翻译： 本文公开的是下式的化合物：其中Ar 1和Ar 2独立地是吡啶基，喹啉基，1,4-苯并二氧杂环戊烷基，二氢-1,4-苯并二恶烷基，吡咯基，氮杂吲哚基或咔唑基或其药学上可接受的盐 ，其可用作平滑肌细胞增殖的抑制剂。
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公开(公告)号：US5654436A
公开(公告)日：1997-08-05
申请号：US477842
申请日：1995-06-07
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61P9/00 , A61P43/00 , C07D235/08 , C07D235/10 , C07D401/04 , C07D235/12
CPC分类号： C07D401/04 , C07D235/08 , C07D235/10
摘要： Disclosed herein are compounds of the formula: ##STR1## where R.sub.1 is alkyl, trifluoromethyl or pyridinyl;R.sub.2 is H, alkyl or substituted arylalkyl, in which the substituents are one or two halogens, carboxyl or alkoxycarbonyl groups;R.sub.3 and R.sub.4 are H, alkyl, halogen or nitro;or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.
摘要翻译： 本文公开的是下式的化合物：其中R 1是烷基，三氟甲基或吡啶基; R2是H，烷基或取代的芳基烷基，其中取代基是一个或两个卤素，羧基或烷氧基羰基; R3和R4是H，烷基，卤素或硝基; 或其药学上可接受的盐，其可用作平滑肌细胞增殖的抑制剂。
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公开(公告)号：US06288100B1
公开(公告)日：2001-09-11
申请号：US08468482
申请日：1995-06-06
IPC分类号： A61K31415
CPC分类号： C07D235/12 , C07D235/08 , C07D235/18
摘要： Disclosed herein are compounds of formula I or II: wherein R is alkyl phenyl or substituted phenyl; R2 is hydrogen, halogen, alkoxy or alkyl; R1 is hydrogen, alkyl, aryl, arylalkyl, or substituted benzyl; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.
摘要翻译： 本文公开的是式I或II的化合物：其中R是烷基苯基或取代的苯基; R 2是氢，卤素，烷氧基或烷基; R 1是氢，烷基，芳基，芳基烷基或取代的苄基;或其药学上可接受的盐， 可用作平滑肌细胞增殖抑制剂。
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4.发明授权Use of 2-substituted benzimidazole as smooth muscle cell proliferation inhibitors 失效使用2-取代苯并咪唑作为平滑肌细胞增殖抑制剂
公开(公告)号：US5763473A
公开(公告)日：1998-06-09
申请号：US761694
申请日：1996-12-06
IPC分类号： A61K31/4184 , A61K31/4439 , A61K31/415
CPC分类号： A61K31/4184 , A61K31/4439
摘要： The use of compounds of the formula: ##STR1## where R.sub.1 is alkyl, trifluoromethyl or pyridinyl; R.sub.2 is H, alkyl or substituted arylalkyl, in which the substituents are one or two halogens, carboxyl or alkoxycarbonyl groups; R.sub.3 and R4 are H, alkyl, halogen or nitro; or a pharmaceutically acceptable salt thereof, as inhibitors of smooth muscle cell proliferation.
摘要翻译： 使用下式的化合物：其中R 1是烷基，三氟甲基或吡啶基; R2是H，烷基或取代的芳基烷基，其中取代基是一个或两个卤素，羧基或烷氧基羰基; R3和R4是H，烷基，卤素或硝基; 或其药学上可接受的盐作为平滑肌细胞增殖的抑制剂。
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公开(公告)号：US06444694B1
公开(公告)日：2002-09-03
申请号：US08468271
申请日：1995-06-06
IPC分类号： A61K31415
CPC分类号： C07D401/06 , A61K31/4184 , C07D235/12 , C07D405/06
摘要： Disclosed herein are compounds of the formula: wherein R is phenyl or substituted phenyl; or R is furyl, pyridyl or quinolinyl; R1 and R2 are hydrogen, halogen, alkyl, alkoxy, nitro, carboxyl, alkoxy-carbonyl or aryloxycarbonyl; R3 is hydrogen, alkyl, aryl or arylalkyl; R4 and R5 are hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.
摘要翻译： 本文公开的是下式的化合物：其中R是苯基或取代的苯基;或R是呋喃基，吡啶基或喹啉基; R1和R2是氢，卤素，烷基，烷氧基，硝基，羧基，烷氧基羰基或芳氧基羰基; R3是氢， 烷基，芳基或芳烷基; R4和R5是氢或烷基;或其药学上可接受的盐，其可用作平滑肌细胞增殖的抑制剂。
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公开(公告)号：US5861517A
公开(公告)日：1999-01-19
申请号：US749367
申请日：1996-11-21
IPC分类号： C07D233/86
CPC分类号： C07D233/86
摘要： The compound of formula I: ##STR1## in which R.sup.1 is alkyl or alkenyl; R.sup.2 is alkyl and R.sup.3 and R.sup.4 are, independently, hydrogen or alkyl; or R.sup.2 is hydrogen and R.sup.3 and R.sup.4 taken together are ortho substituted trimethylene or tetramethylene are useful for increasing blood serum HDL levels.
摘要翻译： 式I化合物：其中R 1是烷基或链烯基; R2是烷基，R3和R4独立地是氢或烷基; 或R2是氢，R3和R4一起是邻位取代的三亚甲基或四亚甲基可用于增加血清HDL水平。
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公开(公告)号：US5783707A
公开(公告)日：1998-07-21
申请号：US754440
申请日：1996-11-21
IPC分类号： C07D233/70 , C07D233/84 , C07D233/86
CPC分类号： C07D233/86
摘要： The compound of formula I ##STR1## in which R.sup.1 is alkyl; and R is alkyl, naphthyl, benzhydryl, fluorophenylmethyl, phenethyl, 1-(fluorophenyl)ethyl, 5-chloro-2-methoxyphenyl, trifluoromethoxyphenyl, trifluoromethylphenyl, methylsulfanylphenyl or pyridyl are useful for increasing blood serum HDL levels.
摘要翻译： 式Ⅰ化合物其中R 1是烷基; 和R是烷基，萘基，二苯甲基，氟苯基甲基，苯乙基，1-（氟苯基）乙基，5-氯-2-甲氧基苯基，三氟甲氧基苯基，三氟甲基苯基，甲硫基苯基或吡啶基可用于提高血清HDL水平。
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公开(公告)号：US5663363A
公开(公告)日：1997-09-02
申请号：US754449
申请日：1996-11-21
IPC分类号： C07D233/86 , C07D233/42 , C07D233/32
CPC分类号： C07D233/86
摘要： The compound of formula I ##STR1## in which R is alkynyl; and X and Y are, independently, alkyl, halo, perfluoralkyl, perfluoralkoxy, or, taken together, X and Y are ortho substituted trimethylene or tetramethylene are useful for increasing blood serum HDL levels.
摘要翻译： 其中R是炔基的式Ⅰ化合物; 并且X和Y独立地是烷基，卤素，全氟烷基，全氟烷氧基，或者X和Y一起是邻位取代的三亚甲基或四亚甲基可用于增加血清HDL水平。
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9.发明授权Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives 失效咪唑并 - 异喹啉-5-酮衍生物，嘧啶并 - 异喹啉-6-酮衍生物和咪唑并 - 萘啶-5-酮衍生物公开(公告)号：US06448255B1
公开(公告)日：2002-09-10
申请号：US09965957
申请日：2001-09-28
IPC分类号： C07D48704
CPC分类号： A61K41/0057
摘要： Antiatherosclerotic compounds are provided which have the following structure: wherein: R is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, heteroaryl, or aryl or heteroaryl substituted with one or more members of the group consisting of alkyl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, and halogen; D is C—H, carbon bound to R5 or nitrogen; R1, R2, R3, and R4 are each independently hydrogen, alkyl, or taken together form a ring; R5 is one or more groups selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, or halogen; n is an integer of 0-3; or pharmaceutically acceptable salts thereof.
摘要翻译： 提供具有以下结构的抗动脉粥样硬化化合物：其中：R是氢，低级烷基，烯基，炔基，芳基，杂芳基或被一个或多个由烷基，羟基，烷氧基，全氟烷基， 全氟烷氧基，烷硫基，硝基，氨基，一或二烷基氨基和卤素; D是CH，与R5或氮键合的碳原子; R1，R2，R3和R4各自独立地为氢，烷基或一起形成环; R5是选自氢，烷基，烯基，炔基，芳基，羟基，烷氧基，全氟烷基，全氟烷氧基，烷硫基，硝基，氨基，单或二烷基氨基或卤素中的一个或多个基团; n是0-3的整数; 或其药学上可接受的盐。
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公开(公告)号：US5821372A
公开(公告)日：1998-10-13
申请号：US754451
申请日：1996-11-21
IPC分类号： C07D233/86 , A61K31/415
CPC分类号： C07D233/86
摘要： The compound of formula I ##STR1## in which R.sup.1 is alkyl, alkenyl, aryl or arylalkyl; R.sup.2 is alkyl, R.sup.3 is a halogen and R.sup.4 is hydrogen; or R.sup.2 is hydrogen, R.sup.3 is a halogen, and R.sup.4 is alkyl are useful for increasing blood serum HDL levels.
摘要翻译： 其中R1是烷基，烯基，芳基或芳基烷基的式Ⅰ化合物; R2是烷基，R3是卤素，R4是氢; 或R 2为氢，R 3为卤素，且R 4为烷基可用于增加血清HDL水平。
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