知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

19 条记录 (耗时 0.014 秒)

    Benzimidazole derivatives
    1.
    发明授权
    Benzimidazole derivatives 失效
    苯并咪唑衍生物

    公开(公告)号：US06288100B1

    公开(公告)日：2001-09-11

    申请号：US08468482

    申请日：1995-06-06

    申请人： Hassan M. Elokdah ,  Sie-Yearl Chai ,  Theodore S. Sulkowski

    发明人： Hassan M. Elokdah ,  Sie-Yearl Chai ,  Theodore S. Sulkowski

    IPC分类号： A61K31415

    CPC分类号： C07D235/12 ,  C07D235/08 ,  C07D235/18

    摘要： Disclosed herein are compounds of formula I or II: wherein R is alkyl phenyl or substituted phenyl; R2 is hydrogen, halogen, alkoxy or alkyl; R1 is hydrogen, alkyl, aryl, arylalkyl, or substituted benzyl; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.

    摘要翻译： 本文公开的是式I或II的化合物：其中R是烷基苯基或取代的苯基; R 2是氢，卤素，烷氧基或烷基; R 1是氢，烷基，芳基，芳基烷基或取代的苄基;或其药学上可接受的盐， 可用作平滑肌细胞增殖抑制剂。

    Styryl benzimidazole derivatives
    3.
    发明授权
    Styryl benzimidazole derivatives 失效
    苯乙烯基苯并咪唑衍生物

    公开(公告)号：US06444694B1

    公开(公告)日：2002-09-03

    申请号：US08468271

    申请日：1995-06-06

    申请人： Sie-Yearl Chai ,  Hassan M. Elokdah ,  Theodore S. Sulkowski

    发明人： Sie-Yearl Chai ,  Hassan M. Elokdah ,  Theodore S. Sulkowski

    IPC分类号： A61K31415

    CPC分类号： C07D401/06 ,  A61K31/4184 ,  C07D235/12 ,  C07D405/06

    摘要： Disclosed herein are compounds of the formula: wherein R is phenyl or substituted phenyl; or R is furyl, pyridyl or quinolinyl; R1 and R2 are hydrogen, halogen, alkyl, alkoxy, nitro, carboxyl, alkoxy-carbonyl or aryloxycarbonyl; R3 is hydrogen, alkyl, aryl or arylalkyl; R4 and R5 are hydrogen or alkyl; or a pharmaceutically acceptable salt thereof, which are useful as inhibitors of smooth muscle cell proliferation.

    摘要翻译： 本文公开的是下式的化合物：其中R是苯基或取代的苯基;或R是呋喃基，吡啶基或喹啉基; R1和R2是氢，卤素，烷基，烷氧基，硝基，羧基，烷氧基羰基或芳氧基羰基; R3是氢， 烷基，芳基或芳烷基; R4和R5是氢或烷基;或其药学上可接受的盐，其可用作平滑肌细胞增殖的抑制剂。

    3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives
    8.
    发明授权
    3-thioxo-[1,2,4]-oxadiazinan-5-one derivatives 失效
    3-硫代 - [1,2,4] - 恶二嗪-5-酮衍生物

    公开(公告)号：US06562814B2

    公开(公告)日：2003-05-13

    申请号：US09965874

    申请日：2001-09-28

    申请人： Hassan M. Elokdah ,  Theodore S. Sulkowski

    发明人： Hassan M. Elokdah ,  Theodore S. Sulkowski

    IPC分类号： A61K31535

    CPC分类号： C07D273/04

    摘要： wherein R is alkyl, alkenyl, or alkynyl; R1 and R2 are each independently hydrogen alkyl, or aryl; and Ar is phenyl, indanyl, benzhydryl, or phenyl, substituted with one or more groups selected from the group consisting of halogen, alkyl, perfluoroalkyl, lower alkoxy, perfluoroalkylalkoxy, dialkylamino, and aroyloxy.

    摘要翻译： 其中R是烷基，烯基或炔基; R 1和R 2各自独立地是烷基或芳基; 并且Ar是被一个或多个选自卤素，烷基，全氟烷基，低级烷氧基，全氟烷基烷氧基，二烷基氨基和芳酰氧基的基团取代的苯基，茚满基，二苯甲基或苯基。

    Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives
    9.
    发明授权
    Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives 失效
    咪唑并 - 异喹啉-5-酮衍生物，嘧啶并 - 异喹啉-6-酮衍生物和咪唑并 - 萘啶-5-酮衍生物

    公开(公告)号：US06448255B1

    公开(公告)日：2002-09-10

    申请号：US09965957

    申请日：2001-09-28

    申请人： Hassan M. Elokdah ,  Theodore S. Sulkowski ,  Sie-Yearl Chai ,  John Babiak

    发明人： Hassan M. Elokdah ,  Theodore S. Sulkowski ,  Sie-Yearl Chai ,  John Babiak

    IPC分类号： C07D48704

    CPC分类号： A61K41/0057

    摘要： Antiatherosclerotic compounds are provided which have the following structure: wherein: R is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, heteroaryl, or aryl or heteroaryl substituted with one or more members of the group consisting of alkyl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, and halogen; D is C—H, carbon bound to R5 or nitrogen; R1, R2, R3, and R4 are each independently hydrogen, alkyl, or taken together form a ring; R5 is one or more groups selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, hydroxy, alkoxy, perfluoroalkyl, perfluoroalkoxy, alkylthio, nitro, amino, mono or di-alkylamino, or halogen; n is an integer of 0-3; or pharmaceutically acceptable salts thereof.

    摘要翻译： 提供具有以下结构的抗动脉粥样硬化化合物：其中：R是氢，低级烷基，烯基，炔基，芳基，杂芳基或被一个或多个由烷基，羟基，烷氧基，全氟烷基， 全氟烷氧基，烷硫基，硝基，氨基，一或二烷基氨基和卤素; D是CH，与R5或氮键合的碳原子; R1，R2，R3和R4各自独立地为氢，烷基或一起形成环; R5是选自氢，烷基，烯基，炔基，芳基，羟基，烷氧基，全氟烷基，全氟烷氧基，烷硫基，硝基，氨基，单或二烷基氨基或卤素中的一个或多个基团; n是0-3的整数; 或其药学上可接受的盐。