公开(公告)号：US4134837A

公开(公告)日：1979-01-16

申请号：US694669

申请日：1976-06-10

申请人： Shuzo Yamashita ,  Shiro Nagata ,  Koichi Takakura

发明人： Shuzo Yamashita ,  Shiro Nagata ,  Koichi Takakura

IPC分类号： A61M1/16 ,  B01D71/38 ,  B01D71/78 ,  B01D71/80 ,  B29D27/04

CPC分类号： B01D71/76 ,  B01D67/0006 ,  B01D61/246 ,  B01D71/26 ,  B01D71/38 ,  Y10S264/62

摘要： Ethylene-vinyl alcohol copolymer membranes characterized by constituent particles having an average diameter within the range of from 100 to 10,000 Angstrom units, determined under an electron microscope for the dry membrane, bonded to each other, wherein the membrane is substantially free from pores in excess of from 2 microns in diameter.Such a membrane has a permeability to water of 10 to 200 .times. 10.sup.-16 cm.sup.2 and to vitamin B.sub.12 of not less than 0.8 .times. 10.sup.-7 cm.sup.2 per second, and being of particular value as a membrane for the dialysis of blood.The membrane is obtained by dissolving an ethylenevinyl alcohol copolymer in a solvent consisting essentially of dimethylsulfoxide or dimethylacetamide and causing the resulting solution to coagulate from an aqueous coagulation bath under mild conditions such that the coagulation time as defined in the specification is not less than 3 seconds.

摘要翻译： 乙烯 - 乙烯醇共聚物膜，其特征在于平均直径在100至10,000埃单位范围内的组成颗粒，在用于干膜的电子显微镜下测定，彼此粘合，其中膜基本上不含过量的孔 直径为2微米。

公开(公告)号：US4269713A

公开(公告)日：1981-05-26

申请号：US71671

申请日：1979-08-31

申请人： Shuzo Yamashita ,  Syuji Kawai ,  Hirokuni Tanii ,  Koichi Takakura

发明人： Shuzo Yamashita ,  Syuji Kawai ,  Hirokuni Tanii ,  Koichi Takakura

IPC分类号： B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B01D71/38 ,  B01D39/18 ,  B01D13/00 ,  B01D31/00

CPC分类号： B01D71/38 ,  B01D67/0009 ,  B01D69/02 ,  B01D69/08 ,  B01D2323/12 ,  B01D2325/02 ,  Y10T428/2975

摘要： There is described an ethylene-vinyl alcohol copolymer membrane comprising at least a skin layer on its surface and a porous layer supporting the skin layer. The porous layer, when the membrane is observed in the dry state with an electron microscope, contains vacuoles or voids, which present a mono- or multi-layer structure and have straight-line lengths corresponding to 20-99% of the whole thickness of the membrane. In addition, the polymer portion of the porous layer has micropores with an average pore diameter of 0.1-5 microns and the membrane has a porosity of 60-90%.

摘要翻译： 描述了在其表面上至少包含表层的乙烯 - 乙烯醇共聚物膜和支撑表皮层的多孔层。 当用电子显微镜在干燥状态下观察膜时，多孔层包含空泡或空隙，其呈现单层或多层结构，并且具有对应于整个厚度的20-99％的直线长度 膜。 此外，多孔层的聚合物部分具有平均孔径为0.1-5微米的微孔，并且膜具有60-90％的孔隙率。

公开(公告)号：US20090005862A1

公开(公告)日：2009-01-01

申请号：US12088000

申请日：2007-01-15

申请人： Tatsuyuki Nakatani ,  Keishi Okamoto ,  Shuzo Yamashita ,  Ikuo Komura ,  Koji Mori

发明人： Tatsuyuki Nakatani ,  Keishi Okamoto ,  Shuzo Yamashita ,  Ikuo Komura ,  Koji Mori

IPC分类号： A61F2/06

CPC分类号： A61L31/084 ,  A61F2/91 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L33/025 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/08

摘要： A stent includes a tubular stent body 11, a diamond-like carbon film 12 formed on the surface of the stent body 11 and having an activated surface, and a polymer layer 13 immobilized on the surface of the diamond-like carbon film. The polymer layer 13 contains a drug 14 having an effect to prevent restenosis, and the drug 14 is gradually released from the polymer layer 13.

摘要翻译： 支架包括管状支架体11，形成在支架主体11的表面上并具有活化表面的类金刚石碳膜12和固定在金刚石状碳膜表面上的聚合物层13。 聚合物层13含有具有防止再狭窄作用的药物14，药物14从聚合物层13逐渐释放。

公开(公告)号：US08435287B2

公开(公告)日：2013-05-07

申请号：US12088000

申请日：2007-01-15

申请人： Tatsuyuki Nakatani ,  Keishi Okamoto ,  Shuzo Yamashita ,  Ikuo Komura ,  Koji Mori

发明人： Tatsuyuki Nakatani ,  Keishi Okamoto ,  Shuzo Yamashita ,  Ikuo Komura ,  Koji Mori

IPC分类号： A61F2/06

CPC分类号： A61L31/084 ,  A61F2/91 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L33/025 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/08

摘要： A stent includes a tubular stent body 11, a diamond-like carbon film 12 formed on the surface of the stent body 11 and having an activated surface, and a polymer layer 13 immobilized on the surface of the diamond-like carbon film. The polymer layer 13 contains a drug 14 having an effect to prevent restenosis, and the drug 14 is gradually released from the polymer layer 13.

摘要翻译： 支架包括管状支架体11，形成在支架主体11的表面上并具有活化表面的类金刚石碳膜12和固定在金刚石状碳膜表面上的聚合物层13。 聚合物层13含有具有防止再狭窄作用的药物14，药物14从聚合物层13逐渐释放。

公开(公告)号：US20090209942A1

公开(公告)日：2009-08-20

申请号：US12301003

申请日：2007-01-15

申请人： Tatsuyuki Nakatani ,  Keishi Okamoto ,  Shuzo Yamashita ,  Koji Mori ,  Ikuo Komura

发明人： Tatsuyuki Nakatani ,  Keishi Okamoto ,  Shuzo Yamashita ,  Koji Mori ,  Ikuo Komura

IPC分类号： A61L27/30 ,  A61L29/10

CPC分类号： A61L31/088 ,  A61F2/0077 ,  A61L31/10 ,  A61M25/0045 ,  C08L43/04

摘要： A medical device includes a medial device body, and a diamond-like thin film covering the medical device body and containing silicon. The diamond-like thin film has a concentration of silicon which is lower in a surface thereof than in an interface thereof with the medical device body mentioned above, and continuously varies.

摘要翻译： 医疗装置包括中间装置主体和覆盖医疗装置主体并且含有硅的金刚石状薄膜。 菱形薄膜的表面的硅浓度比上述医疗装置体的界面低，连续变化。

公开(公告)号：US4362677A

公开(公告)日：1982-12-07

申请号：US270503

申请日：1981-06-04

申请人： Shuzo Yamashita ,  Taku Tanaka ,  Hirokuni Tanii ,  Akira Kubotsu ,  Syuji Kawai

发明人： Shuzo Yamashita ,  Taku Tanaka ,  Hirokuni Tanii ,  Akira Kubotsu ,  Syuji Kawai

IPC分类号： D01F6/04 ,  B01D69/08 ,  B01D71/38 ,  D01D5/24 ,  D01F6/30 ,  D01F6/34 ,  B29D27/00

CPC分类号： D01F6/30 ,  B01D69/08 ,  B01D71/38 ,  D01D5/24 ,  D01F6/34 ,  Y10T428/2935 ,  Y10T428/2975

摘要： A hollow fiber membrane made of an ethylene-vinyl alcohol copolymer is provided, which is characterized in that, when observed in a dry state with an electron microscope, the hollow fiber membrane has at least one dense, active layer (or skin layer) on the inside and/or outside surface thereof and further a three-layered structure comprising two layers respectively contacting the inside and outside surfaces and each consisting of a plurality of particles bonded together and having particle sizes of 0.01 to 2 microns and a substantially particle-free homogeneous layer lying between the two layers.A method of producing such hollow fiber membranes is also provided comprising spinning a spinning solution prepared by dissolving an ethylene-vinyl alcohol copolymer in a solvent mainly consisting of dimethyl sulfoxide, dimethylacetamide, pyrrolidone, N-methylpyrrolidone or a mixture of these through a spinneret for hollow fiber production while simultaneously introducing a coagulating liquid through the central aperture of said spinneret, passing the spun fiber through a gaseous atmosphere such that the fiber is drawn to 3 to 30 times its original length, and coagulating the fiber in a coagulation bath at a temperature within the range specified below:When 15.ltoreq.C.ltoreq.40, -15.ltoreq.T.ltoreq.1/4C+10where C is polymer concentration (weight %) and T is coagulation temperature (.degree.C.).

摘要翻译： 提供一种由乙烯 - 乙烯醇共聚物制成的中空纤维膜，其特征在于，当用电子显微镜在干燥状态下观察时，中空纤维膜具有至少一个致密的有源层（或表层） 其内部和/或外部表面，并且还包括三层结构，其包括分别接触内表面和外表面的两层，并且各自由粘合在一起并具有0.01至2微米的颗粒尺寸和基本上无颗粒的多个颗粒组成 均匀层位于两层之间。 还提供了制造这种中空纤维膜的方法，包括将通过将乙烯 - 乙烯醇共聚物溶解在主要由二甲基亚砜，二甲基乙酰胺，吡咯烷酮，N-甲基吡咯烷酮或它们的混合物的溶剂中制备的纺丝溶液通过喷丝头纺丝 中空纤维生产，同时通过所述喷丝头的中心孔引入凝固液，使纺丝纤维通过气态气氛，使得纤维被拉伸至其原始长度的3至30倍，并将纤维在凝固浴中凝固 温度在下面规定的范围内：当15℃/ 40℃时，-15℃= 1 / 4C + 10其中C是聚合物浓度（重量％），T是凝固温度（℃） ）。

公开(公告)号：US4279795A

公开(公告)日：1981-07-21

申请号：US429207

申请日：1973-12-28

申请人： Shuzo Yamashita ,  Kyoichiro Shibatani ,  Kiochi Takakura ,  Kiyokazu Imai

发明人： Shuzo Yamashita ,  Kyoichiro Shibatani ,  Kiochi Takakura ,  Kiyokazu Imai

IPC分类号： A61L27/16 ,  A61L27/58 ,  A61L33/06 ,  B01D71/38 ,  B01D71/40 ,  B01D71/80 ,  C08F290/04 ,  C08L51/00

CPC分类号： C08F290/04 ,  A61L27/16 ,  A61L27/58 ,  A61L33/064 ,  B01D71/38 ,  B01D71/40 ,  B01D71/80 ,  Y10S524/916

摘要： Materials for forming a hydrogel when contacted with water having improved anti-thrombogenic properties and a highly improved mechanical strength are obtained by the copolymerization of a free radical-polymerizable vinyl monomer capable of forming a hydrophilic polymer and a hydrophobic macromolecular compound having a chain-terminated polymerizable double bond and a molecular weight of 1,000 to 100,000.

摘要翻译： 通过使能够形成亲水性聚合物的自由基聚合性乙烯基单体与具有链终止性的疏水性高分子化合物的共聚，得到与水相接触形成水凝胶的材料，其具有改善的抗血栓形成性能和高度改善的机械强度 可聚合双键，分子量为1,000〜100,000。

公开(公告)号：US4220543A

公开(公告)日：1980-09-02

申请号：US962962

申请日：1978-11-22

申请人： Shuzo Yamashita

发明人： Shuzo Yamashita

IPC分类号： D01F6/34 ,  A61L27/00 ,  A61M1/18 ,  B01D67/00 ,  B01D69/02 ,  B01D71/38 ,  B01D71/78 ,  B01D71/80 ,  B29D27/04

CPC分类号： B01D67/0009 ,  B01D67/0016 ,  B01D69/02 ,  B01D71/38 ,  B01D2323/08 ,  B01D2323/12 ,  B01D2325/022 ,  B01D2325/20

摘要： A membrane made of a composition containing essentially two kinds of ethylene-vinyl alcohol copolymers with different ethylene unit contents and the membrane has such a microstructure that there are at least one active layer and a porous layer thereunder, the porous layer comprises mono- or multi-layer of a plurality of cylindrical voids and a plurality of spherical voids therein and the membrane is of a porosity of 70 to 95%.

摘要翻译： 由含有基本上两种具有不同乙烯单元含量的乙烯 - 乙烯醇共聚物的组合物制成的膜具有这样的微观结构，其中存在至少一个活性层和下面的多孔层，多孔层包括一个或多个 多个圆柱形空隙的层和多个球形空隙，并且该膜的孔隙率为70-95％。

公开(公告)号：US08641756B2

公开(公告)日：2014-02-04

申请号：US13492290

申请日：2012-06-08

申请人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

IPC分类号： A61F2/82

CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

摘要： A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.

摘要翻译： 支架包括具有外表面和内表面的圆柱形构造的支架体，至少涂覆外表面的第一涂层，以及基本上完全覆盖在第一涂层上的第二涂层涂层。 第一涂层由包含不抑制内皮细胞增殖的聚合物和血管内膜增生抑制剂（优选阿加曲班）的第一组合物制备，聚合物与抑制剂的重量组成比在该范围内 8：2到3：7。 另一方面，第二涂层由单独的聚合物或包含聚合物和药物的第二组合物制备，所述药物与所述聚合物的80重量％的重量组成比小于20重量％。

公开(公告)号：US08409272B2

公开(公告)日：2013-04-02

申请号：US12733460

申请日：2008-09-03

申请人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

发明人： Ikuo Omura ,  Zhen Yu Jin ,  Shuzo Yamashita ,  Hiroo Iwata ,  Akira Mochizuki

IPC分类号： A61F2/82

CPC分类号： A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2250/0067 ,  A61K9/0024 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08

摘要： A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer. The first coated layer is prepared of a first composition comprising a polymer and a vascular intimal hyperplasia inhibitor (preferably argatroban) of a kind, which does not inhibit proliferation of endothelial cells, the weight compositional ratio of the polymer to the inhibitor being within the range of 8:2 to 3:7. On the other hand, the second coated layer is prepared of a polymer alone or a second composition comprising a polymer and a drug, the weight compositional ratio of the drug to 80% by weight of the polymer being less than 20% by weight.

摘要翻译： 支架包括具有外表面和内表面的圆柱形构造的支架体，至少涂覆外表面的第一涂层，以及基本上完全覆盖在第一涂层上的第二涂层涂层。 第一涂层由包含不抑制内皮细胞增殖的聚合物和血管内膜增生抑制剂（优选阿加曲班）的第一组合物制备，聚合物与抑制剂的重量组成比在该范围内 8：2到3：7。 另一方面，第二涂层由单独的聚合物或包含聚合物和药物的第二组合物制备，所述药物与所述聚合物的80重量％的重量组成比小于20重量％。