公开(公告)号：US20100047329A1

公开(公告)日：2010-02-25

申请号：US12223722

申请日：2007-02-07

Applicant: Shinobu Watarai ,  Kenji Kono

Inventor： Shinobu Watarai ,  Kenji Kono

IPC: A61K9/127 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K9/127 ,  A61K9/1272 ,  A61K39/005 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/085 ,  A61K39/12 ,  A61K39/17 ,  A61K2039/521 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/55555 ,  C12N2760/18111 ,  C12N2760/18134 ,  C12N2760/18151

Abstract: An object of the present invention is to prepare novel vaccine carriers that can be used to produce vaccines that are capable of efficient induction of humoral and cellular immune responses. Another object of the present invention is to provide vaccines that are capable of efficient induction of humoral and cellular immune responses.The present inventors revealed that the above-stated objects of the present invention could be attained by using liposomes containing succinylated poly(glycidol) and this finding has led to the accomplishment of the invention. Stated specifically, the present invention can attain the aforementioned objects by providing vaccine carriers comprising liposomes containing succinylated poly(glycidol).

Abstract translation: 本发明的目的是制备可用于产生能够有效诱导体液和细胞免疫应答的疫苗的新型疫苗载体。 本发明的另一个目的是提供能够有效诱导体液和细胞免疫应答的疫苗。 本发明人揭示了本发明的上述目的可以通过使用含有琥珀酰化聚（缩水甘油）的脂质体来实现，这一发现导致了本发明的实现。 特别地，本发明可以通过提供包含含有琥珀酰化聚（缩水甘油）的脂质体的疫苗载体来实现上述目的。

公开(公告)号：US20090304658A1

公开(公告)日：2009-12-10

申请号：US12375663

申请日：2007-08-01

Applicant: Shinobu Watarai ,  Shigeru Nishikawa

Inventor： Shinobu Watarai ,  Shigeru Nishikawa

IPC: A61K35/12 ,  C12N5/00 ,  C12M1/00 ,  A61P35/00 ,  A61P37/04 ,  A61P31/00

CPC classification number: C12N5/0638 ,  A61K35/12 ,  A61K2039/515 ,  C12N2501/23 ,  C12N2501/59

Abstract: The present application aims at providing a treatment method effective for various cancers, immune deficiency diseases and infections, and a method of proliferating/activating cells associated therewith, which can be performed at such low costs that the methods can be applicable to nonhuman animals.A method of proliferating/activating cells of the present application comprises steps of, during the cell culture, supplementing a plant lectin (such as concanavalin A) and a growth factor having interleukin-2-like activity to the culture medium. Accordingly, the present method can proliferate/activate, on a preferential basis, aβ-type T cells associated with cell-mediated immunity for cancers, immunodeficiency diseases and infectious diseases.

Abstract translation: 本申请旨在提供对各种癌症，免疫缺陷病和感染有效的治疗方法，以及与其相关的增殖/激活细胞的方法，其可以以低成本进行，以使得该方法可应用于非人动物。 本申请的增殖/活化细胞的方法包括以下步骤：在细胞培养过程中，向培养基补充植物凝集素（如刀豆素A）和具有白细胞介素-2样活性的生长因子。 因此，本发明方法可以优先地增殖/激活与细胞介导的针对癌症，免疫缺陷病和感染性疾病的免疫相关的abeta型T细胞。