公开(公告)号：US4160819A

公开(公告)日：1979-07-10

申请号：US871010

申请日：1978-01-20

Applicant: Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

Inventor： Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

IPC: A61K8/36 ,  A61K8/81 ,  A61K9/06 ,  A61K9/10 ,  A61K9/12 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K31/74 ,  A61K31/78 ,  A61Q17/00 ,  A61Q19/00 ,  A61L9/04 ,  A61K31/13 ,  A61K31/135

CPC classification number: A61K8/8147 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K8/361 ,  A61K9/06 ,  A61Q17/00 ,  A61Q19/00 ,  A61K2800/75

Abstract: A method of inhibiting or reducing the irritation of skin resulting from allergic contact dermatitis, caused by contact with natural or synthetic allergenic agents, e.g. poison ivy, and dinitrochlorobenzene, respectively, is described. The method comprises applying to the skin an irritating reducing effective amount of a protective agent which is an organic compound having at least two polar groups, e.g. carboxyl groups, separated by a chain of at least 15 atoms the majority of which are carbon atoms and optionally containing a cyclic moiety of at least 5 atoms, prior to contact of the skin with the allergenic agent. The protective agent may be combined in a pharmacologically acceptable base for application to the skin.

公开(公告)号：US4137301A

公开(公告)日：1979-01-30

申请号：US871009

申请日：1978-01-20

Applicant: Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

Inventor： Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

IPC: A61K8/36 ,  A61K8/81 ,  A61K9/06 ,  A61K9/10 ,  A61K9/12 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K31/74 ,  A61K31/78 ,  A61Q17/00 ,  A61Q19/00 ,  A61L9/04 ,  A61K31/08

CPC classification number: A61K8/8147 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K8/361 ,  A61K9/06 ,  A61Q17/00 ,  A61Q19/00 ,  A61K2800/75

Abstract: A method of inhibiting or reducing the irritation of skin resulting from allergic contact dermatitis, caused by contact with natural or synthetic allergenic agents, e.g. poison ivy, and dinitrochlorobenzene, respectively, is described. The method comprises applying to the skin an irritating reducing effective amount of a protective agent which is an organic compound having at least two polar groups, e.g. carboxyl groups, separated by a chain of at least 15 atoms the majority of which are carbon atoms and optionally containing a cyclic moiety of at least 5 atoms, prior to contact of the skin with the allergenic agent. The protective agent may be combined in a pharmacologically acceptable base for application to the skin.

公开(公告)号：US4141966A

公开(公告)日：1979-02-27

申请号：US871008

申请日：1978-01-20

Applicant: Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

Inventor： Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

IPC: A61K8/36 ,  A61K8/81 ,  A61K9/06 ,  A61K9/10 ,  A61K9/12 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K31/74 ,  A61K31/78 ,  A61Q17/00 ,  A61Q19/00 ,  A61L9/04 ,  A61K31/19

CPC classification number: A61K8/8147 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K8/361 ,  A61K9/06 ,  A61Q17/00 ,  A61Q19/00 ,  A61K2800/75

Abstract: A method of inhibiting or reducing the irritation of skin resulting from allergic contact dermatitis, caused by contact with natural or synthetic allergenic agents, e.g. poison ivy, and dinitrochlorobenzene, respectively, is described. The method comprises applying to the skin an irritating reducing effective amount of a protective agent which is an organic compound having at least two polar groups, e.g. carboxyl groups, separated by a chain of at least 15 atoms the majority of which are carbon atoms and optionally containing a cyclic moiety of at least 5 atoms, prior to contact of the skin with the allergenic agent. The protective agent may be combined in a pharmacologically acceptable base for application to the skin.

公开(公告)号：US4144319A

公开(公告)日：1979-03-13

申请号：US871012

申请日：1978-01-20

Applicant: Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

Inventor： Sharon G. Willer ,  Paul R. Yust ,  Ralph Kelly

IPC: A61K8/36 ,  A61K8/81 ,  A61K9/06 ,  A61K9/10 ,  A61K9/12 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K31/74 ,  A61K31/78 ,  A61Q17/00 ,  A61Q19/00 ,  A61L9/04 ,  A61K31/25

CPC classification number: A61K8/8147 ,  A61K31/20 ,  A61K31/205 ,  A61K31/23 ,  A61K8/361 ,  A61K9/06 ,  A61Q17/00 ,  A61Q19/00 ,  A61K2800/75

Abstract: A method of inhibiting or reducing the irritation of skin resulting from allergic contact dermatitis, caused by contact with natural or synthetic allergenic agents, e. g. poison ivy, and dinitrochlorobenzene, respectively, is described. The method comprises applying to the skin an irritating reducing effective amount of a protective agent which is an organic compound having at least two polar groups, e.g. carboxyl groups, separated by a chain of at least 15 atoms the majority of which are carbon atoms and optionally containing a cyclic moiety of at least 5 atoms, prior to contact of the skin with the allergenic agent. The protective agent may be combined in a pharmacologically acceptable base for application to the skin.

Abstract translation: 一种抑制或减少由与天然或合成过敏原接触导致的过敏性接触性皮炎引起的皮肤刺激的方法， G。 毒藤和二硝基氯苯分别被描述。 该方法包括向皮肤施用刺激性还原有效量的作为具有至少两个极性基团的有机化合物的保护剂，例如， 羧基，其由至少15个原子的链分开，其中大多数是碳原子，并且任选地含有至少5个原子的环状部分，在皮肤与变应原剂接触之前。 保护剂可以组合在药理学上可接受的基质中以用于皮肤。