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公开(公告)号:US20240280558A1
公开(公告)日:2024-08-22
申请号:US18578513
申请日:2022-07-13
申请人: Seer, Inc.
发明人: Theodore Platt , Iman Mohtashemi , Hugo Kitano , Asim Siddiqui
IPC分类号: G01N33/487 , G01N30/86 , G01N33/68
CPC分类号: G01N33/48792 , G01N30/8631 , G01N33/6848
摘要: In some aspects, the present disclosure provides a method for normalizing and processing mass spectrometry datasets. In some embodiments, the method comprises loading a plurality of mass spectrometry data obtained from a plurality of samples into a memory of a computing node to generate a cached dataset. In some embodiments, the method comprises transmitting a copy of the cached dataset to a plurality of cache memories of a plurality of computing nodes. In some embodiments, the method comprises determining, using the plurality of computing nodes, a plurality of feature values for the plurality of mass spectrometry data. In some embodiments, the method comprises normalizing, using the plurality of computing nodes, across the plurality of mass spectrometry datasets using the plurality of feature values to generate a plurality of normalized mass spectrometry data.
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公开(公告)号:US20240219400A1
公开(公告)日:2024-07-04
申请号:US18557753
申请日:2022-04-29
申请人: Seer, Inc.
发明人: Asim Siddiqui , Daniel Hornburg , Craig Stolarczyk , Yina Li , Hongwei Xia
IPC分类号: G01N33/68 , G01N33/531 , G01N33/543
CPC分类号: G01N33/6851 , G01N33/531 , G01N33/54346 , G01N2333/976
摘要: The present disclosure provides a range of compositions and methods for enriching subsets of complex biological samples. Aspects of the present disclosure provide peptide-functionalized particles comprising affinities for subsets of biomolecules from complex biological samples. The present disclosure further provides methods for utilizing functionalized particles to fractionate and analyze complex biological samples.
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公开(公告)号:US20240125795A1
公开(公告)日:2024-04-18
申请号:US18547831
申请日:2022-02-25
申请人: Seer, Inc.
发明人: Daniel Hornburg , Craig Stolarczyk , Behzad Tangeysh , Asim Siddiqui , Tristan Brown , Shadi Roshdiferdosi , Martin Goldberg , Moaraj HASAN
IPC分类号: G01N33/68 , G01N33/543
CPC分类号: G01N33/6848 , G01N33/54346
摘要: Disclosed herein are methods for identifying physicochemical properties associated with protein corona formation at the level of proteins and NP-functionalization. Further disclosed herein are compositions comprising combinations of particles configured for low abundance protein collection and deep proteomic analysis.
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