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公开(公告)号：US10597367B2
公开(公告)日：2020-03-24
申请号：US15950683
申请日：2018-04-11
发明人： Nicholas David Peter Cosford , Dhanya Raveendra-Panickar , Douglas J. Sheffler , John Howard Hutchinson , Reto Andreas Gadient
IPC分类号： C07D243/12 , A61K31/551 , A61P25/00 , C07D243/14 , A61K31/4196 , A61K31/426 , A61K31/427 , A61K31/433 , C07D217/06 , C07D417/04 , C07D249/08 , C07D277/20 , C07D285/08 , C07D403/12 , C07D233/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/04 , C07D239/26 , C07D409/04 , C07D271/06 , C07D275/02 , C07D277/30 , A61K31/505 , A61K31/506 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/26 , C07D307/38 , C07D333/24 , C07D401/14 , C07D405/10 , C07D409/02 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/10 , C07D417/14
摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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公开(公告)号：US11447453B2
公开(公告)日：2022-09-20
申请号：US16817209
申请日：2020-03-12
发明人： Nicholas David Peter Cosford , Dhanya Raveendra-Panickar , Douglas J. Sheffler , John Howard Hutchinson , Reto Andreas Gadient
IPC分类号： C07D277/20 , C07D285/08 , C07D249/08 , A61K31/426 , A61K31/433 , A61K31/4196 , A61P25/00 , C07D243/14 , A61K31/427 , C07D217/06 , C07D417/04 , C07D403/12 , C07D233/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/04 , C07D239/26 , C07D409/04 , C07D243/12 , C07D271/06 , C07D275/02 , C07D277/30 , A61K31/505 , A61K31/506 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/26 , C07D307/38 , C07D333/24 , C07D401/14 , C07D405/10 , C07D409/02 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/10 , C07D417/14
摘要： Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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