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    PREPARATION OF ERTAPENEM INTERMEDIATES
    2.
    发明申请
    PREPARATION OF ERTAPENEM INTERMEDIATES 有权
    ERTAPENEM中间体的制备

    公开(公告)号：US20150274732A1

    公开(公告)日：2015-10-01

    申请号：US14434550

    申请日：2013-10-11

    Applicant: Sandoz AG

    Inventor： Hannes Lengauer ,  Birgit Endl ,  Wolfgang Felzmann

    IPC: C07D477/20

    CPC classification number: C07D477/08 ,  C07B2200/13 ,  C07D477/20

    Abstract: The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof.

    Abstract translation: 本发明涉及化合物的制备，特别是涉及可用作制备抗生素，优选碳青霉烯类抗生素，更优选厄来替班及其盐的中间体的化合物的制备。

    PROCESS FOR THE SYNTHESIS OF TELAPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF
    4.
    发明申请
    PROCESS FOR THE SYNTHESIS OF TELAPREVIR, OR PHARMACEUTICALLY ACCEPTABLE SALTS OR SOLVATES AS WELL AS INTERMEDIATE PRODUCTS THEREOF 审中-公开
    合成TELAPREVIR或药物可接受的盐或溶剂作为其中间产物的方法

    公开(公告)号：US20150038677A1

    公开(公告)日：2015-02-05

    申请号：US14384268

    申请日：2013-03-15

    Applicant: SANDOZ AG

    Inventor： Wolfgang Felzmann ,  Stefanie Brunner ,  Thorsten Wilhelm

    IPC: C07K5/117 ,  C07K5/08

    CPC classification number: C07K5/1024 ,  C07B2200/13 ,  C07D403/12 ,  C07K5/0202 ,  C07K5/08

    Abstract: The invention relates to a process for the preparation of telaprevir, or a pharmaceutically acceptable salt or solvate thereof, wherein the process requires a smaller number of process steps and/or does not require the use of toxic and instable compounds compared to the known processes. Another embodiment refers to telaprevir, or a pharmaceutically acceptable salt or solvate thereof as well as to intermediate products for preparation of the same, wherein the afore-mentioned products are obtained by the process described herein.

    Abstract translation: 本发明涉及一种制备特拉匹韦或其药学上可接受的盐或溶剂化物的方法，其中与已知方法相比，该方法需要较少数量的工艺步骤和/或不需要使用有毒和不稳定的化合物。 另一个实施方案是指特拉匹韦或其药学上可接受的盐或溶剂化物以及用于制备其的中间产物，其中上述产物通过本文所述的方法获得。

    Active Acrylamides
    7.
    发明申请
    Active Acrylamides 审中-公开

    公开(公告)号：US20180282336A1

    公开(公告)日：2018-10-04

    申请号：US15522889

    申请日：2015-10-29

    Applicant: Sandoz AG

    Inventor： Wolfgang Felzmann ,  Stefanie Brunner ,  Hannes Lengauer

    IPC: C07D487/04 ,  A61K31/519 ,  C07D211/42 ,  C07D487/14

    Abstract: The present invention refers to the synthesis and intermediates of substituted bicyclic compounds, which are used as a masked form of acrylamides and in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (ibrutinib) and its synthesis intermediates.

    Preparation of ertapenem intermediates
    9.
    发明授权
    Preparation of ertapenem intermediates 有权
    ertapenem中间体的制备

    公开(公告)号：US09546171B2

    公开(公告)日：2017-01-17

    申请号：US14434550

    申请日：2013-10-11

    Applicant: Sandoz AG

    Inventor： Hannes Lengauer ,  Birgit Endl ,  Wolfgang Felzmann

    IPC: C07D477/08 ,  C07D477/20

    CPC classification number: C07D477/08 ,  C07B2200/13 ,  C07D477/20

    Abstract: The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof.

    Abstract translation: 本发明涉及化合物的制备，特别是涉及可用作制备抗生素，优选碳青霉烯类抗生素，更优选厄来替班及其盐的中间体的化合物的制备。

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