公开(公告)号：US20150024447A1

公开(公告)日：2015-01-22

申请号：US14335632

申请日：2014-07-18

Applicant: Samsung Electronics Co., Ltd.

Inventor： Ji-eun KIM ,  Jin-woo Park ,  Jin-hwan Park ,  Yu-kyung Jung ,  Hwa-young Cho ,  Jae Chan Park ,  Kwang-myung Cho

IPC: C12P7/18 ,  C12N9/02

CPC classification number: C12P7/18 ,  C12N9/0008 ,  C12Y102/01057

Abstract: A mutant butyraldehyde dehydrogenase (Bld), a polynucleotide having a nucleotide encoding the mutant, a vector including the polynucleotide, a microorganism including a nucleotide encoding the mutant, and a method of producing 1,4-butanediol using the same.

Abstract translation: 突变体丁醛脱氢酶（Bld），具有编码突变体的核苷酸的多核苷酸，包含该多核苷酸的载体，包含编码该突变体的核苷酸的微生物，以及使用其的1,4-丁二醇的制造方法。

公开(公告)号：US08921083B2

公开(公告)日：2014-12-30

申请号：US13946179

申请日：2013-07-19

Applicant: Samsung Electronics Co., Ltd.

Inventor： Woo Yong Lee ,  Hyun Min Koo ,  Sung Soo Kim ,  Jae Young Kim ,  Jae Chan Park

IPC: C07K14/34 ,  C12N15/77 ,  C12P7/18 ,  C12P7/62 ,  C08G63/16 ,  C08G63/183 ,  C12N9/90 ,  C12N9/10

CPC classification number: C12P7/18 ,  C07K14/34 ,  C08G63/16 ,  C08G63/183 ,  C12N9/1029 ,  C12N9/90 ,  C12N15/77 ,  C12P7/62

Abstract: A modified microorganism for producing a high yield of 1,4-butanediol, and a method of producing 1,4-butanediol using the modified microorganism, wherein the modified microorganism is altered so as to delete or disrupt expression of at least one of transcription regulatory factor NCg12886, GCN5-related N-acetyltransferase NCg12090, hypothetical protein NCg10224 or sugar phosphate isomerase/epimerase NCg12956.

Abstract translation: 用于生产高产量的1,4-丁二醇的改性微生物以及使用该修饰的微生物生产1,4-丁二醇的方法，其中改变的微生物被改变以便删除或破坏至少一种转录调节物的表达 因子NCg12886，GCN5相关N-乙酰转移酶NCg12090，假想蛋白NCg10224或糖磷酸异构酶/差向异构酶NCg12956。