公开(公告)号：US10294217B2

公开(公告)日：2019-05-21

申请号：US15758313

申请日：2016-07-19

Applicant: Suven Life Sciences Limited

Inventor： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Abdul Rasheed Mohammed ,  Ramkumar Subramanian ,  Vijay Sidram Benade ,  Gopinadh Bhyrapuneni ,  Venkateswarlu Jasti

IPC: A61P25/28 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor. (Formula I)(I)

公开(公告)号：US20180244655A1

公开(公告)日：2018-08-30

申请号：US15758313

申请日：2016-07-19

Applicant: Suven Life Sciences Limited

Inventor： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Abdul Rasheed Mohammed ,  Ramkumar Subramanian ,  Vijay Sidram Benade ,  Gopinadh Bhyrapuneni ,  Venkateswarlu Jasti

IPC: C07D403/06 ,  C07D401/06 ,  C07D417/06 ,  C07D401/14 ,  C07D401/12 ,  C07D417/14 ,  A61P25/28

CPC classification number: C07D403/06 ,  A61P25/28 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D417/06 ,  C07D417/14

Abstract: The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor. (Formula I) (I)

公开(公告)号：US09957257B2

公开(公告)日：2018-05-01

申请号：US15549663

申请日：2016-01-07

Applicant: SUVEN LIFE SCIENCES LIMITED

Inventor： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Abdul Rasheed Mohammed ,  Sangram Keshari Saraf ,  Narsimha Bogaraju ,  Ramkumar Subramanian ,  Pradeep Jayarajan ,  Gopinadh Bhyrapuneni ,  Venkateswarlu Jasti

IPC: C07D405/12 ,  C07D405/14

CPC classification number: C07D405/12 ,  C07D405/14

Abstract: The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to 5-hydroxytryptamine 4 (5-HT4) receptor.

公开(公告)号：US12122779B2

公开(公告)日：2024-10-22

申请号：US17285432

申请日：2019-10-16

Applicant: SUVEN LIFE SCIENCES LIMITED

Inventor： Ramakrishna Nirogi ,  Abdul Rashee Mohammed ,  Anil Karbhari Shinde ,  Srinivasa Rao Ravella ,  Ramkumar Subramanian ,  Venkateswarlu Jasti

IPC: C07D487/04 ,  A61K45/06 ,  A61P1/00 ,  A61P25/00

CPC classification number: C07D487/04 ,  A61K45/06 ,  A61P1/00 ,  A61P25/00

Abstract: The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt(s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of such compounds. (I)