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公开(公告)号：US20190117560A1
公开(公告)日：2019-04-25
申请号：US16225485
申请日：2018-12-19
发明人： Samarth KUMAR , Prashant KANE , Subhas Balaram BHOWMICK , Milan Natvarbhai THAKKAR , Kandarp Maheshkumar DAVE
IPC分类号： A61K9/00 , A61K9/08 , A61K31/4468 , A61K47/26
摘要： A method of treating a patient in need of therapy with fentanyl or a salt thereof, the method comprising providing a ready-to-administer solution consisting essentially of fentanyl or a salt thereof as the sole active ingredient, a sugar or sugar alcohol and water for injection, the solution having a pH in the range of 3.5 to 7.5, and parenterally administering the solution to the patient.
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公开(公告)号：US20190008847A1
公开(公告)日：2019-01-10
申请号：US15748878
申请日：2016-08-01
发明人： Subhas Balaram BHOWMICK , Prashant KANE , Samarth KUMAR , Ramaji Karshanbhai VARU , Nisarg Bipinchandra MISTRY , Swapnil Ramesh PATIL
IPC分类号： A61K31/475 , A61K9/00
摘要： The present invention relates to a dosage form comprising an aqueous solution of a vinca alkaloid drug or its pharmaceutically acceptable salt in a flexible infusion container, and a light protective secondary packaging containing the flexible infusion container, wherein the dosage form is ready-to-infuse and wherein the aqueous solution is stable at room temperature.
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公开(公告)号：US20240165016A1
公开(公告)日：2024-05-23
申请号：US18418053
申请日：2024-01-19
发明人： Samarth KUMAR , Ramaji Karshanbhai VARU , Nishit PATEL , Prashant KANE , Subhas Balaram BHOWMICK
CPC分类号： A61K9/0019 , A61J1/10 , A61K9/08 , A61K31/519 , B32B27/08 , B32B27/306 , B32B27/32
摘要： The present invention relates to an intravenous infusion dosage form comprising: an aqueous solution of pemetrexed or its pharmaceutically acceptable salt at a concentration ranging from 1.0 mg/ml to 20.0 mg/ml present in a multilayered flexible plastic infusion container, wherein the multilayered flexible plastic infusion container has an oxygen scavenger layer sandwiched between an outermost and an innermost layer of the container, the container being free of a polyimide and wherein the multilayered flexible plastic infusion container filled with the aqueous solution of pemetrexed is autoclavable.
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公开(公告)号：US20230158226A1
公开(公告)日：2023-05-25
申请号：US18057595
申请日：2022-11-21
CPC分类号： A61M5/14 , A61K9/0019 , A61M5/16827 , A61M5/1407 , A61M2205/6009
摘要： A perfusion container for directly administering to patients a dose of an antineoplastic drug calculated according to a patient's parameter, wherein the first perfusion container comprises a solution of antineoplastic drug at a concentration and volume such that the amount of antineoplastic drug in the container is equal to the calculated dose for one patient but less than the calculated dose for a second patient, the calculated dose is provided to first patient within 5% variance by directly administering the full volume of the solution of antineoplastic drug from the first perfusion container, further the first perfusion container is accompanied by a second top-up perfusion container comprising a solution of antineoplastic drug at a concentration and volume such that the calculated dose is provided within 5% variance by directly administering the full volume of the solution of antineoplastic drug from the first perfusion container and the second top-up container to the second patient.
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公开(公告)号：US20180036310A1
公开(公告)日：2018-02-08
申请号：US15550638
申请日：2016-02-12
发明人： Samarth KUMAR , Prashant KANE , Subhas Balaram BHOWMICK , Kirti GANORKAR , Nisarg Bipinchandra MISTRY , Ramaji Karshanbhai VARU
IPC分类号： A61K31/519 , A61K41/00 , A61K9/08 , B65B55/06 , A61J1/10 , B65B3/00 , B65B7/02 , A61K9/00 , A61K47/02
CPC分类号： A61K31/519 , A61J1/10 , A61K9/0019 , A61K9/08 , A61K41/0009 , A61K47/02 , A61M5/14 , B65B3/003 , B65B7/02 , B65B55/06
摘要： The present invention relates to an intravenous infusion dosage form of pemetrexed or its pharmaceutically acceptable salt, having long term stability.
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公开(公告)号：US20190105262A1
公开(公告)日：2019-04-11
申请号：US16156575
申请日：2018-10-10
发明人： Samarth KUMAR , Ramaji Karshanbhai VARU , Nishit PATEL , Prashant KANE , Subhas Balaram BHOWMICK
IPC分类号： A61K9/00 , A61K31/519 , A61K9/08 , A61J1/10
摘要： The present invention relates to an intravenous infusion dosage form comprising: an aqueous solution of pemetrexed or its pharmaceutically acceptable salt at a concentration ranging from 1.0 mg/ml to 20.0 mg/ml present in a multilayered flexible plastic infusion container, wherein the multilayered flexible plastic infusion container has an oxygen scavenger layer sandwiched between an outermost and an innermost layer of the container, the container being free of a polyamide and wherein the multilayered flexible plastic infusion container filled with the aqueous solution of pemetrexed is autoclavable.
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公开(公告)号：US20180064703A1
公开(公告)日：2018-03-08
申请号：US15694243
申请日：2017-09-01
发明人： Samarth KUMAR , Prashant KANE , Subhas Balaram BHOWMICK , Milan Natvarbhai THAKKAR , Kandarp Maheshkumar DAVE
IPC分类号： A61K31/485 , A61K9/00 , A61K9/08 , A61K47/02 , A61L2/00 , A61J1/10 , A61J1/14 , B65D81/26 , B65D81/20 , B65D77/00 , A61M5/00
CPC分类号： A61K31/485 , A61J1/10 , A61J1/1468 , A61K9/0019 , A61K9/08 , A61K47/02 , A61L2/0023 , A61L2202/21 , A61L2202/23 , A61M5/002 , A61M2209/06 , B65D77/003 , B65D81/2015 , B65D81/2023 , B65D81/2076 , B65D81/2084 , B65D81/267
摘要： The present invention relates to an infusion dosage form comprising (i) an aqueous solution of morphine or its pharmaceutically acceptable salt as a sole active ingredient in a concentration ranging from about 0.1 mg/ml to about 10.0 mg/ml, filled in containers in volumes ranging from about 50 ml to about 250 ml, and having dissolved oxygen content of less than 2 ppm, (ii) the container being surrounded by an outer covering, and (iii) an inert gas or vacuum is present in the space between the container and outer covering, wherein the infusion dosage form is sterilized by autoclaving and is stable upon autoclaving, and further wherein the space between the container and outer covering does not have an oxygen scavenger pouch before or during autoclaving.
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公开(公告)号：US20170340579A1
公开(公告)日：2017-11-30
申请号：US15606261
申请日：2017-05-26
发明人： Madhusudhan BOMMAGANI , Pijush Kanti MIDYA , Krunal RAVAL , Subhas Balaram BHOWMICK , Prashant KANE
IPC分类号： A61K9/70 , B65D81/26 , A61K31/4458 , A61F15/00 , A61J1/00
CPC分类号： A61K9/7053 , A61F15/001 , A61J1/00 , A61K31/4458 , B65D81/268
摘要： A transdermal delivery system comprising a drug-containing matrix layer, a release liner and a backing layer. The drug-containing matrix layer further comprises a methylphenidate base, an adhesive polymer made up of a styrene rubber block copolymer having a styrene content of 24% or above by weight of the adhesive polymer; the adhesive polymer is present in an amount of 20% to 45% by weight of the drug-containing matrix layer, a tackifier present in an amount of 30% to 45% by weight of the drug-containing matrix layer, and a hydrocarbon plasticizer present in an amount of 1% to 30% by weight of the drug-containing matrix layer.
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公开(公告)号：US20160367476A1
公开(公告)日：2016-12-22
申请号：US15185452
申请日：2016-06-17
发明人： Samarth KUMAR , Prashant KANE , Subhas Balaram BHOWMICK , Milan Natvarbhai THAKKAR , Kandarp Maheshkumar DAVE
IPC分类号： A61K9/00 , A61K47/26 , A61K31/4468
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/4468 , A61K47/26
摘要： A method of treating a patient in need of therapy with fentanyl or a salt thereof, the method comprising providing a ready-to-administer solution consisting essentially of fentanyl or a salt thereof as the sole active ingredient, a sugar or sugar alcohol and water for injection, the solution having a pH in the range of 3.5 to 7.5, and parenterally administering the solution to the patient.
摘要翻译： 一种治疗需要用芬太尼或其盐治疗的患者的方法，所述方法包括提供基本上由芬太尼或其盐作为唯一活性成分，糖或糖醇和水的即用型溶液，其用于 注射，溶液的pH在3.5至7.5的范围内，并且将溶液肠胃外施用于患者。
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