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    PARTICLES, METHODS AND USES THEREOF
    3.
    发明申请
    PARTICLES, METHODS AND USES THEREOF 审中-公开
    颗粒，方法及其用途

    公开(公告)号：US20150258218A1

    公开(公告)日：2015-09-17

    申请号：US14423946

    申请日：2013-08-30

    申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

    发明人： Moritz Kircher ,  Stefan Harmsen ,  Matthew Wall

    IPC分类号： A61K49/00 ,  A61K51/12

    CPC分类号： A61K49/0093 ,  A61K49/00 ,  A61K49/0002 ,  A61K49/1878 ,  A61K49/1881 ,  A61K51/1251

    摘要： The present disclosure, among other things, provides a composition including a nanoscale core; a plurality of capping agent entities associated on the core; an outer encapsulant layer; and a plurality of dopant entities distributed at locations selected from the group consisting of: on or within the nanoscale core, on or between capping agent entities, on or within the encapsulating layer, and combinations thereof. Provided technologies can achieve unprecedented levels of dopant entity density and/or surface localization, which, for a SE(R)RS-active agent dopant, results in dramatically improved signal intensity and/or imaging sensitivity.

    摘要翻译： 本公开内容尤其提供了包括纳米尺度核心的组合物; 在核心上相关联的多个封盖代理实体; 外包封层; 以及分布在选自以下的位置处的多个掺杂剂实体以及其组合：在纳米级核心上或纳米级核心之上，覆盖剂实体之间或之上，在封装层上或封装层内。 所提供的技术可以实现前所未有的掺杂剂实体密度和/或表面定位水平，对于SE（R）RS-活性剂掺杂剂，其导致显着改善的信号强度和/或成像灵敏度。

    Multimodal particles, methods and uses thereof
    4.
    发明授权
    Multimodal particles, methods and uses thereof 有权

    公开(公告)号：US10105456B2

    公开(公告)日：2018-10-23

    申请号：US14653177

    申请日：2013-12-19

    申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

    发明人： Stefan Harmsen ,  Matthew Wall ,  Moritz Kircher

    IPC分类号： A61K49/00 ,  A61K49/18 ,  A61K51/12

    摘要： The present disclosure, among other things, provides a composition of a particle including a substrate; at least a first condensation layer comprising at least a first dopant entity; and at least a second layer comprising a second dopant entity. In some embodiments, different dopant entities are included in different layers. In some embodiments, such dopant entities are or comprise detectable entities. This, in some embodiments, provided technologies achieve multi-modality particles. Among the many advantages of provided technologies include the ability to image particles by a plurality of distinct imaging modalities and/or in a plurality of contexts (e.g., pre-surgical, intraoperative and/or post-surgical environments). The present invention provides methods that include a single administration of particles to a subject, followed by a plurality of steps that comprise imaging the administered particles, which steps may utilize different imaging technologies and/or be performed at different times and/or in different environments.

    Particles, methods and uses thereof
    5.
    发明授权
    Particles, methods and uses thereof 有权

    公开(公告)号：US10322194B2

    公开(公告)日：2019-06-18

    申请号：US14423946

    申请日：2013-08-30

    申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

    发明人： Moritz Kircher ,  Stefan Harmsen ,  Matthew Wall

    IPC分类号： A61K49/00 ,  A61K51/12 ,  A61K49/18

    摘要： The present disclosure, among other things, provides a composition including a nanoscale core; a plurality of capping agent entities associated on the core; an outer encapsulant layer; and a plurality of dopant entities distributed at locations selected from the group consisting of: on or within the nanoscale core, on or between capping agent entities, on or within the encapsulating layer, and combinations thereof. Provided technologies can achieve unprecedented levels of dopant entity density and/or surface localization, which, for a SE(R)RS-active agent dopant, results in dramatically improved signal intensity and/or imaging sensitivity.