公开(公告)号：US20200046674A1

公开(公告)日：2020-02-13

申请号：US16654168

申请日：2019-10-16

申请人： SK BIOPHARMACEUTICALS CO., LTD.

发明人： Young-Soon KANG ,  Jin-Yong CHUNG ,  Cheol-Young MAENG ,  Han-Ju YI ,  Ki-Ho LEE ,  Joon HEO ,  Eun-Hee CHAE ,  Yu-Jin SHIN

IPC分类号： A61K31/325 ,  C07C275/60 ,  A61K45/06 ,  A61K31/27 ,  A61P25/00 ,  A61K9/00

摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

公开(公告)号：US20210113514A1

公开(公告)日：2021-04-22

申请号：US17136153

申请日：2020-12-29

申请人： SK BIOPHARMACEUTICALS CO., LTD.

发明人： Young-Soon KANG ,  Jin-Yong CHUNG ,  Cheol-Young MAENG ,  Han-Ju YI ,  Ki-Ho LEE ,  Joon HEO ,  Eun-Hee CHAE ,  Yu-Jin SHIN

IPC分类号： A61K31/325 ,  A61K9/00 ,  C07C275/60 ,  A61K45/06 ,  A61P25/00 ,  A61K31/27

摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

公开(公告)号：US20230218562A1

公开(公告)日：2023-07-13

申请号：US18124697

申请日：2023-03-22

申请人： SK BIOPHARMACEUTICALS CO., LTD.

发明人： Young-Soon KANG ,  Jin-Yong CHUNG ,  Cheol-Young MAENG ,  Han-Ju YI ,  Ki-Ho LEE ,  Joon HEO ,  Eun-Hee CHAE ,  Yu-Jin SHIN

IPC分类号： C07C275/60 ,  A61K45/06 ,  A61P25/26

CPC分类号： C07C275/60 ,  A61K45/06 ,  A61P25/26

摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound:






wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

公开(公告)号：US20190247356A1

公开(公告)日：2019-08-15

申请号：US16395422

申请日：2019-04-26

申请人： SK BIOPHARMACEUTICALS CO., LTD.

发明人： Young-Soon KANG ,  Jin-Yong CHUNG ,  Cheol-Young MAENG ,  Han-Ju YI ,  Ki-Ho LEE ,  Joon HEO ,  Eun-Hee CHAE ,  Yu-Jin SHIN

IPC分类号： A61K31/325 ,  A61P25/00 ,  A61K9/00 ,  C07C275/60 ,  A61K45/06 ,  A61K31/27

CPC分类号： A61K31/325 ,  A61K9/0053 ,  A61K31/27 ,  A61K45/06 ,  A61P25/00 ,  C07C275/60

摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

公开(公告)号：US20180085337A1

公开(公告)日：2018-03-29

申请号：US15805293

申请日：2017-11-07

申请人： SK BIOPHARMACEUTICALS CO., LTD.

发明人： Young-Soon KANG ,  Jin-Yong CHUNG ,  Cheol-Young MAENG ,  Han-Ju YI ,  Ki-Ho LEE ,  Joon HEO ,  Eun-Hee CHAE ,  Yu-Jin SHIN

IPC分类号： A61K31/325 ,  A61K31/27 ,  A61K45/06 ,  C07C275/60 ,  A61K9/00

CPC分类号： A61K31/325 ,  A61K9/0053 ,  A61K31/27 ,  A61K45/06 ,  A61P25/00 ,  C07C275/60

摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

公开(公告)号：US20160303067A1

公开(公告)日：2016-10-20

申请号：US15195326

申请日：2016-06-28

申请人： SK BIOPHARMACEUTICALS CO., LTD.

发明人： Young-Soon KANG ,  Jin-Yong CHUNG ,  Cheol-Young MAENG ,  Han-Ju YI ,  Ki-Ho LEE ,  Joon HEO ,  Eun-Hee CHAE ,  Yu-Jin SHIN

IPC分类号： A61K31/325 ,  A61K45/06 ,  A61K9/00

CPC分类号： A61K31/325 ,  A61K9/0053 ,  A61K31/27 ,  A61K45/06 ,  C07C275/60

摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

公开(公告)号：US20150246874A1

公开(公告)日：2015-09-03

申请号：US14633388

申请日：2015-02-27

申请人： SK BIOPHARMACEUTICALS CO., LTD.

发明人： Young-Soon KANG ,  Jin-Yong CHUNG ,  Cheol-Young MAENG ,  Han-Ju YI ,  Ki-Ho LEE ,  Joon HEO ,  Eun-Hee CHAE ,  Yu-Jin SHIN

IPC分类号： C07C275/60 ,  A61K31/27 ,  A61K45/06

CPC分类号： A61K31/325 ,  A61K9/0053 ,  A61K31/27 ,  A61K45/06 ,  C07C275/60

摘要： The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R1 and R2 are independently H— or alkyl; R3 is H—, alkyl or aralkyl; and R4 is H— or aryl.

摘要翻译： 本公开内容提供了作为多巴胺再摄取抑制剂有效的由式（I）表示的化合物和药学上可接受的盐以及使用该化合物的方法：其中X独立地为卤素，烷基，烷氧基或硝基; m为0,1,2,3或4; n为1或2; R1和R2独立地为H或烷基; R3是H，烷基或芳烷基; R4是H或芳基。