公开(公告)号：US20220334089A1

公开(公告)日：2022-10-20

申请号：US17636047

申请日：2020-02-28

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke NAGAI ,  Yosuke IWATA

IPC: G01N30/20

Abstract: A sample injection device is used to inject a sample into a chromatograph and includes a flow vial, a sampling needle and one or more than one sample dissolution devices. A sample is supplied to the flow vial. The sample that has been supplied to the flow vial is collected by the sampling needle and injected into the chromatograph. At least one of ultrasonic waves, an electric field and a magnetic field is used, so that dissolution of a sample to be injected into the chromatograph is promoted by one or more than one sample dissolution devices.

公开(公告)号：US20250050300A1

公开(公告)日：2025-02-13

申请号：US18793757

申请日：2024-08-03

Applicant: SHIMADZU CORPORATION ,  WASEDA UNIVERSITY

Inventor： Yusuke NAGAI ,  Yosuke IWATA ,  Takeo SUGA

IPC: B01J19/00

Abstract: A synthesis system includes a first flow-path portion, a second flow-path portion, a third flow-path portion and a switcher. The first flow-path portion is connected to a first container in which a liquid raw material is containable. The second flow-path portion is connected to a second container in which a liquid raw material is containable. The third flow-path portion connects the first container and the second container to each other. To the third flow-path portion, a synthesis reaction device that produces a reactant from a liquid raw material is connected. The switcher is switchable between a flow-path state in which gas supplied by a gas supplier is guided to the first flow-path portion and a flow-path state in which gas supplied by the gas supplier is guided to the second flow-path portion.

公开(公告)号：US20220260535A1

公开(公告)日：2022-08-18

申请号：US17630125

申请日：2019-08-05

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke NAGAI

IPC: G01N30/74

Abstract: A detector for liquid chromatograph includes a light source, a flow cell that includes a linear capillary, a holding member that holds one end portion of the capillary, an entrance port for allowing light to enter one end of the capillary, and an emission port for allowing light to be emitted from another end of the capillary, a condensing mirror for guiding light from the light source to the entrance port, and a light receiver for detecting the light emitted from the emission port, a lens is provided between the one end of the capillary and the condensing mirror, and the lens is arranged so as to parallelize light in a center region around an optical axis among light directed to the one end of the capillary from the condensing mirror and distance a first reflection position of the light in the center region from the one end.

公开(公告)号：US20230314390A1

公开(公告)日：2023-10-05

申请号：US18105398

申请日：2023-02-03

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke NAGAI ,  Yosuke IWATA

IPC: G01N30/86 ,  G01N30/14 ,  G01N30/38 ,  B01D15/08

CPC classification number: G01N30/8665 ,  G01N30/14 ,  G01N30/38 ,  B01D15/08 ,  G01N2030/385 ,  G01N2030/027

Abstract: A monitoring analysis device includes an acquirer that sequentially acquires reaction products produced by a reactor, an analyzer that sequentially analyzes the reaction products acquired by the acquirer, a pre-processor that performs a pre-process to be performed before an analysis of the reaction products by the analyzer, and a controller that controls the pre-processor such that the pre-process for a second analysis to be performed subsequently to a first analysis is performed during the first analysis by the analyzer.

公开(公告)号：US20220171375A1

公开(公告)日：2022-06-02

申请号：US17509020

申请日：2021-10-24

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke NAGAI

IPC: G05B19/418

Abstract: To prevent operation of an analysis system from being stopped every time an error occurs in an analysis device of a monitoring system. A monitoring system includes an analysis device provided with a plurality of sensors, an error detector configured to detect occurrence of an error in the analysis device based on an output signal of a plurality of the sensors, and to identify a type of the detected error, an information storage part storing levels set in advance for each of a plurality of types of errors that may occur in the analysis device, and an error level identification part configured to identify a level of an error detected by the error detector based on information stored in the information storage part Where an error occurs in the analysis device, a measure according to the level of the error identified is executed in the analysis device.

公开(公告)号：US20190187045A1

公开(公告)日：2019-06-20

申请号：US16318789

申请日：2016-08-25

Applicant: Shimadzu Corporation

Inventor： Yusuke NAGAI ,  Masato WATANABE

IPC: G01N21/01

Abstract: A flow cell includes a housing, a window member, and a pressing member. The housing includes a cell channel in which a sample flows through, has, on at least one end side of the cell channel, an opening communicating with the cell channel, and has a flat surface at an edge of the opening. The window member has a lens portion at a central portion and a peripheral edge portion whose one surface and the other surface are flat. In the window member, one surface of the peripheral edge portion is provided facing the flat surface of the housing so as to seal the opening.

公开(公告)号：US20180246060A1

公开(公告)日：2018-08-30

申请号：US15754405

申请日：2015-08-24

Applicant: Shimadzu Corporation

Inventor： Yusuke NAGAI

IPC: G01N27/62

CPC classification number: G01N27/622 ,  G01N27/62

Abstract: A rectangular cylindrical drift cell is formed by bonding four resistive film layer members in which a resistive film layer having a uniform film thickness is formed on a surface of a plate member formed of an insulator of alumina or the like through a coating method or a vapor deposition. A predetermined voltage is applied from a drift voltage generator to the resistive film layers of both ends of the drift cell so that an accelerating electric field having a linear potential gradient is formed along a center axis (C) in a desolvation region and a drift region inside the drift cell. Ions are drifted by the accelerating electric field and are separated in response to the ion mobility.

公开(公告)号：US20160313248A1

公开(公告)日：2016-10-27

申请号：US15135626

申请日：2016-04-22

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke NAGAI ,  Keisuke OGAWA ,  Masato WATANABE ,  Kumiko JINGU ,  Masanori FUJIWARA ,  Tomoyuki YAMAZAKI

IPC: G01N21/64 ,  G01N21/25 ,  G01N21/31

CPC classification number: G01N21/645 ,  G01N21/255 ,  G01N2021/641 ,  G01N2201/06153

Abstract: Light emitted from a light casting unit 1 including an LED as its light source is cast into a sample cell 2, and a photodetector 3 is placed at a position where the resultant passing light can be detected. The LED is driven to blink, and a data extracting section 71 extracts data obtained in a period in which the LED is turned on, as data (absorbance data) in which absorption of light by the sample solution is reflected. Moreover, in the case where a fluorescent component is contained in the sample solution, fluorescent light is emitted by the cast light serving as excitation light. Even after the excitation light ceases, the emission of the fluorescent light continues for a short time, and hence the data extracting section 71 extracts data obtained immediately after the LED is turned off, as data (fluorescence data) in which the fluorescent light is reflected. An absorbance computing section 72 calculates absorbance based on the absorbance data, and a fluorescence computing section 73 calculates fluorescence intensity based on the fluorescence data. Accordingly, it is possible to simultaneously perform an absorbance measurement and a fluorescence measurement on one sample while using one photodetector and thus simplifying the configuration of an optical system.

Abstract translation: 从包括LED作为其光源的光铸造单元1发射的光被投射到样品池2中，并且将光电检测器3放置在可以检测所得到的通过光的位置。 LED被驱动闪烁，并且数据提取部71提取在LED被接通的时段中获得的数据作为反映样品溶液的光吸收的数据（吸光度数据）。 此外，在样品溶液中含有荧光成分的情况下，作为激发光的投射光发出荧光。 即使在激发光停止之后，荧光的发射持续很短的时间，因此数据提取部71提取在关闭LED之后立即获得的数据作为反射荧光的数据（荧光数据） 。 吸光度计算部72基于吸光度数据计算吸光度，荧光运算部73基于荧光数据计算荧光强度。 因此，可以在使用一个光电检测器的同时对一个样品进行吸光度测量和荧光测量，从而简化了光学系统的结构。

公开(公告)号：US20240302250A1

公开(公告)日：2024-09-12

申请号：US18594095

申请日：2024-03-04

Applicant: SHIMADZU CORPORATION ,  DIRECTOR GENERAL OF NATIONAL INSTITUTE OF HEALTH SCIENCES

Inventor： Takuya YOSHIOKA ,  Yosuke IWATA ,  Yusuke NAGAI ,  Katsumasa SAKAMOTO ,  Takuji SHODA ,  Tomoaki SAKAMOTO

IPC: G01N1/20 ,  G01N1/14 ,  G01N1/40

CPC classification number: G01N1/20 ,  G01N1/14 ,  G01N1/40

Abstract: A liquid sampling method in a flow monitoring system including a sampling section having a needle for performing sampling of a liquid, an analysis section that performs analysis of the liquid sampled by the sampling section, and a fluid supply section that supplies a sample fluid in a state of gas-liquid two-phase flow containing a gas phase and a liquid phase with the sample remaining in the state of gas-liquid two-phase flow. The liquid sampling method includes: a storage step of storing, in the storage container, a liquid phase contained in the sample fluid; a separation step of separating, from a liquid phase, a gas phase contained in the liquid phase stored in the storage container; and an injection step of suctioning, as a sample, the liquid phase stored in the storage container from a distal end of the needle after the separation step and injecting a predetermined amount of the sample into the analysis section through the injection port.

公开(公告)号：US20230324261A1

公开(公告)日：2023-10-12

申请号：US18132371

申请日：2023-04-08

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke NAGAI ,  Yosuke IWATA ,  Tomoyuki YAMAZAKI

IPC: G01N1/20 ,  G01N1/14

CPC classification number: G01N1/2035 ,  G01N1/14 ,  G01N2001/205

Abstract: It is an object to enable a sample of a sample source to be injected into a LC while a pressure state of the sample source is maintained. There are provided an injector (2) including a first sample loop (18) and an injection valve (20), a sample supply channel (26), a pump part (4), a second sample loop (12), a sample source channel (52), and a path construction part. The path construction part is configured to be capable of selectively constructing a sampling path and a sample supply path. The sampling path is configured so that the sample source channel (52) and the pump part (4) are fluidly connected to each other in a closed system with the second sample loop (12) interposed therebetween and the sample is drawn from the sample source to the second sample loop (12) using the pump part (4), and the sample supply path is configured so that the second sample loop (12) is separated from the sample source channel (52) while maintaining a closed system state of the sample source channel (52) and the pump part (4) or another pump (40) different from the pump part and the sample supply channel (26) are fluidly connected to each other with the second sample loop (12) interposed therebetween and the sample held in the second sample loop (12) is supplied to the injector (2) through the sample supply channel (26) using the pump part (4) or the other pump (40).