公开(公告)号：US20250044304A1

公开(公告)日：2025-02-06

申请号：US18784874

申请日：2024-07-25

Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. ,  HyTest Ltd.

Inventor： Karina R. Seferian ,  Evgenia O. Kuzichkina ,  Erzhena G. Altaeva ,  Fedor N. Rozov ,  Stanislav V. Kozlovsky ,  Yury N. Lezhnin ,  Kristina M. Gaynova ,  Liudmila V. Ageeva ,  Natalia A. Gruzdeva ,  Natalia N. Tamm ,  Elizaveta D. Kulieva ,  Anna A. Trufanova ,  Sergei A. Kotlov ,  Chengxiong ZHAN ,  Qixue SONG ,  Tao TANG ,  Yufeng YAN ,  Ke LI

IPC: G01N33/76 ,  C07K16/26 ,  G01N21/76 ,  G01N33/53

Abstract: The present application relates to an antibody, kit, detection method, and sample analyzer for detecting thyroid stimulating hormone. Specifically, the present application relates to a monoclonal antibody or antigen-binding antibody fragment thereof that specifically binds to thyroid stimulating hormone (TSH), wherein the antibody can recognize TSH variant R55G and does not cross-react with an α-subunit shared by human luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), and free glycoprotein hormones, and is particularly suitable for developing TSH detection kit with a functional sensitivity of ≤0.0015 μIU/ml. The present application also relates to a thyroid stimulating hormone detection kit, detection method, and sample analyzer.

公开(公告)号：US20250034236A1

公开(公告)日：2025-01-30

申请号：US18784880

申请日：2024-07-25

Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. ,  HyTest Ltd.

Inventor： Alexander G. Semenov ,  Evgeniya E. Feygina ,  Elizaveta E. Sokolova ,  Chengxiong ZHAN ,  Xiaotong LI ,  Tao TANG ,  Puguang CHEN ,  Ke LI

IPC: C07K16/18 ,  G01N33/564 ,  G01N33/574

Abstract: This application provides an antibody or antigen-binding fragment thereof that binds to thyroglobulin, including: a heavy chain variable region having: CDR-H1 having an amino acid sequence selected from SEQ ID NOs: 1, 7, 13, 19, 25, 31, and variants thereof, CDR-1-12 having an amino acid sequence selected from SEQ ID NOs: 2, 8, 14, 20, 26, 32, and variants thereof, and CDR-H3 having an amino acid sequence selected from SEQ ID NOs: 3, 9, 15, 21, 27, 33, and variants thereof; and a light chain variable region having: CDR-L1 having an amino acid sequence selected from SEQ ID NOs: 4, 10, 16, 22, 28, 34, and variants thereof, CDR-L2 having an amino acid sequence selected from SEQ ID NOs: 5, 11, 17, 23, 29, 35, and variants thereof, and CDR-L3 having an amino acid sequence selected from SEQ ID NOs: 6, 12, 18, 24, 30, 36, and variants thereof.

公开(公告)号：US20240360205A1

公开(公告)日：2024-10-31

申请号：US18648572

申请日：2024-04-29

Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. ,  HyTest Ltd.

Inventor： Vladimir L. Filatov ,  Petr N. Datskevich ,  Antonina S. Kokisheva ,  Alexey G. Katrukha ,  Stanislav V. Kozlovsky ,  Alexander B. Postnikov ,  Fedor N. Rozov ,  Tao TANG ,  Chengxiong ZHAN ,  Lingjia WU ,  Shibo ZHU ,  Ke LI ,  Yue WU

IPC: C07K16/18 ,  G01N33/68

CPC classification number: C07K16/18 ,  G01N33/6854 ,  C07K2317/565

Abstract: The present application relates to a PINP-specific antibody, kit and use thereof. Specifically, the present invention provides a PINP-specific antibody, as well as a kit containing the antibody, and use thereof in detecting the presence or level of tPINP in a sample.