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公开(公告)号：US20210371536A1
公开(公告)日：2021-12-02
申请号：US17281058
申请日：2019-10-07
申请人： Seoul National University R&DB Foundation , Ewha University - industry Collaboration Foundation
发明人： Soohyun KIM , Hyori KIM , Dong Hyun JO , Jeong Hun KIM , Suree KIM , Dongmin KANG , Dobeen HWANG , Junho CHUNG
摘要： The present invention relates to an antibody against a PDGF receptor, an antibody-drug conjugate in which a chemotherapeutic agent is conjugated to the antibody against PDGF receptor, and a use of prevention or treatment of ocular neovascular diseases.
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公开(公告)号：US20190328894A1
公开(公告)日：2019-10-31
申请号：US16309577
申请日：2017-06-21
发明人： Junho CHUNG , Junyeong JIN , Hyori KIM , Gunwoo PARK , Soohyun KIM
IPC分类号： A61K47/68 , C07K16/46 , A61K47/65 , A61P35/00 , A61K31/4188 , A61K31/407 , C07K16/28
摘要： The present invention relates to an antibody drug conjugate using a bispecific antibody and its use. The antibody drug conjugate of the present invention can easily form a conjugate of an antibody and a drug without a multistep synthetic process though binding of a conjugate of a bivalent cotinine-peptide and a drug, and an anti-cotinine single chain variable fragment. In addition, the antibody drug conjugate can effectively deliver a drug to a target to which the antibody binds specifically, and can enhance a half-life of a drug in the body, thereby improving a therapeutic effect.
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公开(公告)号：US20230238535A1
公开(公告)日：2023-07-27
申请号：US18010183
申请日：2021-08-10
发明人： Soohyun KIM , Jong-Chan LEE , Seokin CHOI , Kwonnam SOHN , Dong Gi HONG , Ji-Hoon BAIK , Jin Hong LEE
IPC分类号： H01M4/62 , H01M10/052
CPC分类号： H01M4/622 , H01M10/052 , H01M2004/028
摘要： Disclosed are a positive electrode binder for a lithium secondary battery capable of improving battery performance, by being constituted by a cationic monomer, and thus capturing lithium polysulfide that occurs during charging and discharging of the battery, and a positive electrode for a lithium secondary battery and a lithium secondary battery comprising the same. The positive electrode binder for the lithium secondary battery comprises a cationic (meth)acrylate-based monomer containing one or more cations, or a derivative thereof.
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公开(公告)号：US20220384782A1
公开(公告)日：2022-12-01
申请号：US17775258
申请日：2021-08-10
发明人： Soohyun KIM , Jong-Chan LEE , Seokin CHOI , Kwonnam SOHN , Daun JEONG , Huiseob SHIN
IPC分类号： H01M4/36 , H01M4/587 , H01M4/38 , H01M10/0525
摘要： Disclosed are a positive electrode for a lithium secondary battery which can improve battery performance by coating the modified bottom-up graphene oxide (SBGO) on the positive electrode active material, and thus preventing the leaching of lithium polysulfide, a manufacturing method thereof, and a lithium secondary battery comprising the positive electrode. The positive electrode for the lithium secondary battery includes a positive electrode active material; and bottom-up graphene oxides coated on a surface of the positive electrode active material, where the bottom-up graphene oxides are cross-linked with each other through a hydrocarbon compound containing a cationic functional group.
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公开(公告)号：US20180256744A1
公开(公告)日：2018-09-13
申请号：US15753212
申请日：2016-08-17
发明人： Kyungho CHOI , Hyung-Bae PARK , Ji Eun LEE , Yumi OH , Ki-Hyun KIM , Soohyun KIM , Hyori KIM , Junho CHUNG
CPC分类号： A61K47/6819 , A61K35/17 , A61K38/17 , A61K39/395 , A61K39/39558 , A61P35/00 , C07K16/16 , C07K16/2809 , C07K16/2818 , C07K2317/53 , C07K2317/622 , C07K2317/73 , C07K2319/02 , C07K2319/03 , C07K2319/10 , C12N15/85
摘要： The present invention relates to chimeric antibody receptors with anti-cotinine antibodies linked, and use thereof. A T cell presenting the chimeric antibody receptor on the surface secretes interferon gamma specifically for a target molecule of a cotinine-conjugated binding molecule that is added together therewith and induces cell death of the cell expressing the target molecule by the T cell. On the contrary, by administering a cytotoxic agent conjugated with cotinine, cell death of the chimeric antigen receptor T cell is induced. Therefore, if necessary, a cytotoxic agent conjugated with cotinine can be administered to remove the chimeric antigen receptor T cells that have been already administered, thereby suppressing immune side effects due to hyperactivity of T cells. Thus, the chimeric antigen receptor to which the anti-cotinine antibody is linked can be effectively and safely used for the treatment of cancer.
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公开(公告)号：US20220411269A1
公开(公告)日：2022-12-29
申请号：US17781301
申请日：2021-08-10
发明人： Soohyun KIM , Jong-Chan LEE , Kihyun KIM , Kwonnam SOHN , Daun JEONG
IPC分类号： C01B32/198 , H01M10/052 , C01B32/194
摘要： Disclosed are a positive electrode coating material for a lithium secondary battery including graphene oxide surface-modified with cationic functional groups, a preparation method thereof, and a positive electrode and a lithium secondary battery comprising the coating material. The positive electrode coating material prevents the leaching of lithium polysulfide, thereby improving battery performance.
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公开(公告)号：US20220393157A1
公开(公告)日：2022-12-08
申请号：US17776508
申请日：2021-08-04
发明人： Soohyun KIM , Jong-Chan LEE , Kihyun KIM , Kwonnam SOHN , Daun JEONG , Chan Yeong KOONG
IPC分类号： H01M4/36 , H01M4/58 , H01M4/62 , H01M10/0525 , H01M4/04
摘要： The present disclosure relates to a positive electrode active material, a preparation method thereof, and a lithium-sulfur battery including the same, more particularly to a positive electrode active material including a particulate structure of a core-shell structure which comprises a core part and a shell part covering the whole surface or a part of the surface of the core part, wherein the core part comprises a sulfur compound, and the shell part comprises a polythiophene acetic acid-polyethylene glycol graft copolymer. The positive electrode active material of the present disclosure has excellent electrochemical reactivity and adsorbs lithium polysulfide to improve capacity and lifetime characteristics of the lithium-sulfur battery.
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