公开(公告)号：US20190329197A1

公开(公告)日：2019-10-31

申请号：US16504612

申请日：2019-07-08

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Sebastien CHAUSSIN ,  Jeremy GIBELIN ,  Stefan ZEUCH ,  Michael BATES

IPC: B01F13/08 ,  C12M1/00 ,  B01F3/04 ,  B01F15/00 ,  B65D77/06 ,  B01F7/00 ,  B01F7/22 ,  B01F7/16

Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

公开(公告)号：US20180221838A1

公开(公告)日：2018-08-09

申请号：US15750048

申请日：2016-08-02

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Sebastien CHAUSSIN ,  Jeremy GIBELIN ,  Stefan ZEUCH ,  Michael BATES

IPC: B01F13/08 ,  B01F15/00 ,  B01F3/04 ,  C12M1/00

CPC classification number: B01F13/0836 ,  B01F3/04248 ,  B01F3/04531 ,  B01F7/00633 ,  B01F7/00716 ,  B01F7/00725 ,  B01F7/1695 ,  B01F7/22 ,  B01F15/0085 ,  B01F2003/04326 ,  B01F2003/04673 ,  B01F2215/0032 ,  B01F2215/0073 ,  B65D77/06 ,  C12M23/26

Abstract: Disclosed is a method for assembling a mixer-container intended for receiving a biopharmaceutical fluid in which: a container is provided, the container including: a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to the wall, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container is provided; a drive motor located outside the container is provided; the first bearing of the container is placed so as to be spaced apart from the motor; the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

公开(公告)号：US20160186906A1

公开(公告)日：2016-06-30

申请号：US14392172

申请日：2014-06-25

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Florian BLAKE ,  Jeremy GIBELIN

IPC: F16L37/098 ,  A61M39/10 ,  A61M39/16 ,  F16L33/025

CPC classification number: F16L37/098 ,  A61J1/1481 ,  A61M39/1011 ,  A61M39/165 ,  A61M39/18 ,  A61M2039/1027 ,  A61M2039/1066 ,  A61M2205/6072 ,  A61M2205/6081 ,  F16L33/025 ,  F16L2201/10 ,  F16L2201/44

Abstract: Fluid-connection device for connecting a flexible pipe defining a first fluid space to a second flexible pipe or a flexible fluid enclosure in a biopharmaceutical assembly, includes a first connector and a second connector equivalent thereto, the first connector and second connector adapted to be coupled together in a genderless manner, by an insertion movement that is essentially an axial translation, into a relative coupling position, which defines a mating plane, each of the connectors including, in an alternating manner along the circumferential direction, N flexible snap-fitting tabs and N stop surfaces, the flexible snap-fitting tabs projecting axially forwards relative to the mating plane, and the stop surfaces being set back from the mating plane so that, in the coupling position, the snap-fitting tabs of one connector clip into place on the stop surfaces of the other connector, such that the resulting position is locked by the snap-fitting tabs.

Abstract translation: 用于将限定第一流体空间的柔性管连接到生物药物组件中的第二柔性管或柔性流体外壳的流体连接装置包括第一连接器和等效于其的第二连接器，所述第一连接器和第二连接器适于被联接 通过基本上是轴向平移的插入运动，以无性别的方式组合成限定配合平面的相对联接位置，每个连接器沿着圆周方向以交替的方式包括N个柔性卡扣配合片 和N个止动表面，柔性卡扣配件突片相对于配合平面轴向向前突出，并且止动表面从配合平面回缩，使得在联接位置，将一个连接器夹的卡扣配合片固定到位 在另一个连接器的停止表面上，使得所得到的位置被卡扣配合片锁定。

公开(公告)号：US20170138518A1

公开(公告)日：2017-05-18

申请号：US15323804

申请日：2015-06-29

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Florian BLAKE ,  Jeremy GIBELIN

IPC: F16L33/207 ,  F16L33/22

CPC classification number: F16L13/146 ,  F16L33/2071 ,  F16L33/2076 ,  F16L33/225

Abstract: A fluid connection set includes a connector (1), a flexible hose (2), and a crimping collar (5) for fixing the front end of the flexible hose to the connector, the connector including a connector body (10), a tubular nozzle (3), the tubular nozzle including retaining radial projections (31) of the hose as well as a clamping area (30) of the hose, and a temporary accommodation space (4), arranged between the tubular nozzle (3) and the connector body (10), for housing the collar during the operation of inserting the flexible tube, after which the collar is moved with respect to the clamping area and then crimped.

公开(公告)号：US20170051859A1

公开(公告)日：2017-02-23

申请号：US15118794

申请日：2015-02-11

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Florian BLAKE ,  Jeremy GIBELIN

IPC: F16L37/084 ,  F16B21/18

CPC classification number: F16L37/0841 ,  F16B21/186

Abstract: A female connector (1) configured to receive a male connector (2), having an annular exterior retaining rim (24), the female connector including a body (10), and a transverse slide (4) forming a housing, the housing (4) including two lateral grooves (41,42), the female connector including a separate deformable locking ring (3) capable of being inserted in the housing and of locking the male connector in the coupling position, the locking ring including two first concave arched portions (31), as viewed from the axis, and two second arched portions (32), with inverse curvature, i.e. convex when viewed from the axis, the second arched portions being capable of flexing towards the exterior during insertion of the male connector and capable of abutting on the external annular retaining rim and preventing withdrawal of the male connector, whereby after locking of the male connector in the female connector a definitive locking is obtained.

Abstract translation: 一个阴连接器（1），其构造成接收具有环形外部保持边缘（24）的阳连接器（2），所述阴连接器包括主体（10）和形成壳体的横向滑动件（4） 4）包括两个横向凹槽（41,42），阴连接器包括能够插入壳体中并将阳连接器锁定在联接位置的单独的可变形锁定环（3），该锁定环包括两个第一凹形拱形 从轴线观察的部分（31）和两个第二拱形部分（32），具有相反的曲率，即当从轴线观察时是凸的，所述第二拱形部分能够在插入阳连接器期间朝向外部弯曲，并且 能够抵靠外部环形保持边缘并防止阳连接器的撤回，由此在公连接器锁定在阴连接器中之后，获得了明确的锁定。

公开(公告)号：US20160369922A1

公开(公告)日：2016-12-22

申请号：US14901582

申请日：2014-06-25

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Florian BLAKE ,  Jeremy GIBELIN

IPC: F16L37/098 ,  A61J1/14 ,  F16L33/025

CPC classification number: F16L37/0987 ,  A61J1/1481 ,  A61J2205/60 ,  A61M39/1011 ,  A61M2039/1027 ,  F16L33/025 ,  F16L2201/10 ,  F16L2201/44 ,  F16L2201/60

Abstract: Disclosed is a fluid-connection device for connecting a first wall defining a first fluid space, for example a flexible pipe, to a second wall defining a second fluid space, in the form of a flexible pipe or enclosure, including a first male connector, the first connector including a seal and a snap-fitting collar, the seal extending radially prior to coupling from the axis until a first radial distance R1, a second female connector capable of receiving the first connector, the second connector including at least one flexible tab with one end against which the locking collar abuts in coupling position, in order to prevent retraction from the coupling position, the flexible tab being defined relative to the axis between a second radial distance R2 and a third radial distance R3, which is greater than the second radial distance R2, wherein R2>R1.

Abstract translation: 公开了一种用于将限定第一流体空间（例如柔性管）的第一壁连接到限定第二流体空间的第二壁的流体连接装置，该第二流体空间以柔性管或外壳的形式包括第一阳连接器， 所述第一连接器包括密封件和卡扣配合套环，所述密封件在从所述轴线到第一径向距离R1的耦合之前径向延伸，第二阴连接器能够接收所述第一连接器，所述第二连接器包括至少一个柔性突片 其中锁定套环的一端与联接位置邻接，为了防止从联接位置退回，柔性突片相对于第二径向距离R2和第三径向距离R3之间的轴限定，该第二径向距离R3大于 第二径向距离R2，其中R2> R1。

公开(公告)号：US20160146386A1

公开(公告)日：2016-05-26

申请号：US14901524

申请日：2014-06-24

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Florian BLAKE ,  Jeremy GIBELIN ,  Sabelle GAY

IPC: F16L37/08 ,  F16L57/00 ,  A61M39/10 ,  F16L33/02

CPC classification number: F16L37/08 ,  A61J1/1481 ,  A61M39/1011 ,  A61M39/12 ,  A61M2039/1027 ,  A61M2039/1066 ,  F16L33/02 ,  F16L33/025 ,  F16L33/227 ,  F16L37/0987 ,  F16L57/00 ,  F16L2201/10 ,  F16L2201/44

Abstract: Disclosed is a fluid-connection device for connecting a first wall defining a first fluid space, in the form of a flexible pipe, to a second wall defining a second fluid space, in the form of a flexible or rigid disposable pipe or enclosure, in a biopharmaceutical assembly, including a first connector in fluid communication with the first space, the first connector including a tubular nozzle for receiving the pipe by insertion along the axis A, a pipe clamp arranged around the end of the pipe in order to clamp the pipe onto the tubular nozzle of the first connector, a protective cover forming a separate part, capable of being snap-fit in an operative position in which the cover is at least partially surrounding the first connector and the pipe clamp thereof, by way of which the pipe clamp cannot come into direct contact with external elements.

Abstract translation: 公开了一种流体连接装置，其用于将限定以柔性管的形式的第一流体空间的第一壁连接到限定具有柔性或刚性的一次性管或外壳形式的第二流体空间的第二壁， 生物药物组件，包括与第一空间流体连通的第一连接器，第一连接器包括用于通过沿着轴线A插入来接收管的管状喷嘴，围绕管端部布置的管夹，以便夹紧管 在第一连接器的管状喷嘴上，形成独立部件的保护盖，其能够卡扣配合在其中盖至少部分地围绕第一连接器及其管夹的操作位置，通过该盖 管夹不能直接与外部元件接触。

公开(公告)号：US20170045169A1

公开(公告)日：2017-02-16

申请号：US15118769

申请日：2015-02-11

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Jeremy GIBELIN ,  Florian BLAKE

IPC: F16L37/084

CPC classification number: F16L37/0841 ,  F16L37/00 ,  F16L37/08 ,  F16L37/084 ,  F16L37/088 ,  F16L2201/44

Abstract: Female connector for accepting a male connector having a retaining external annular rim, a slot including two parallel lateral grooves and the slot opening at least at one of its ends forming a mouth of the housing, the female connector including a locking slide distinct from the body, movable between a locking position and an unlocking position, the locking slide including a locking plate and an actuating knob formed integrally with the plate, with a retaining portion belonging to the locking plate to come into abutment against the retaining outer annular rim, the locking slide including at least one flexible tab formed integrally, returning the slide toward the first position, the flexible tab pressing on each side of the mouth in the axial direction X so that the return force is balanced about X and creates no torque that could have a tendency to cause the locking plate to jam.

Abstract translation: 用于接纳具有保持外部环形边缘的阳连接器的阴连接器，包括两个平行横向凹槽的槽，并且至少在其一个端部处形成狭缝开口，形成壳体的口部，阴连接器包括不同于主体的锁定滑块 ，可在锁定位置和解锁位置之间移动，所述锁定滑动件包括锁定板和与所述板一体形成的致动旋钮，所述保持部分属于所述锁定板以抵靠所述保持外部环形边缘，所述锁定 滑动件包括一体地形成的至少一个柔性凸片，使滑动件朝向第一位置返回，柔性凸片在轴向方向X上按压嘴的每一侧，使得返回力在X平衡，并且不产生可能具有 导致锁板卡住的趋势。

公开(公告)号：US20170045168A1

公开(公告)日：2017-02-16

申请号：US15118715

申请日：2015-02-11

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Florian BLAKE ,  Jeremy GIBELIN

IPC: F16L37/084

CPC classification number: F16L37/0841 ,  A61M39/00 ,  A61M39/10

Abstract: A modular fluid connection assembly includes a female connector (1) for fluid connection, provided to receive a male connector (2) having an external annular retaining rim (24), the female connector including a body (10) with an axial bore X, and a slide forming a transverse housing (4), the housing (4) including two parallel lateral grooves (41, 42) and the housing opening at at least one of its ends (40) along the direction of the slide Z, the assembly including a non-unlocking locking element (3), in the form of a deformable locking ring (3), the assembly including an unlocking locking element (5), in the form of a locking slider (5), in which the female connector is configured to receive equally either a non-unlocking element, or an unlocking element.

Abstract translation: 模块化流体连接组件包括用于流体连接的阴连接器（1），用于容纳具有外部环形保持边缘（24）的阳连接器（2），阴连接器包括具有轴向孔X的主体（10） 以及形成横向壳体（4）的滑块，所述壳体（4）沿着所述滑动件Z的方向在其至少一个端部（40）处包括两个平行的横向槽（41,42）和所述壳体开口，所述组件 包括可变形锁定环（3）形式的非解锁锁定元件（3），所述组件包括呈锁定滑块（5）形式的解锁锁定元件（5），其中所述母连接器 被配置为同样接收非解锁元件或解锁元件。

公开(公告)号：US20160178101A1

公开(公告)日：2016-06-23

申请号：US14392169

申请日：2014-06-26

Applicant: SARTORIUS STEDIM FMT SAS

Inventor： Florian BLAKE ,  Jeremy GIBELIN ,  Isabelle GAY

IPC: F16L33/22 ,  A61J1/20 ,  F16L37/098

CPC classification number: F16L33/225 ,  A61J1/1481 ,  A61J1/2048 ,  A61M39/1011 ,  A61M39/12 ,  A61M2039/1027 ,  F16L33/221 ,  F16L37/0987 ,  F16L2201/44

Abstract: Disclosed is a coupling device for sealingly coupling a first wall defining a flexible pipe (11) to a tubular nozzle (9) of a connector (1) in a biopharmaceutical assembly, the coupling device including the connector (1) including the tubular nozzle (9), on which one end of the pipe can be inserted along an axis A, a plurality of flexible tabs (3) extending from an intermediate area (7) of the coupling body toward the free end (la) of the nozzle, an abutment clamp (16), a connection interface (6), a separate ring (2), axially movable between an inoperative position and an operative position, for covering the flexible tabs (3) such as to push same radially inward in order to press the pipe onto the nozzle in the operative position, the tabs extending substantially parallel to the axis (A) when the ring (2) is in the operative position.

Abstract translation: 公开了一种用于将限定柔性管道（11）的第一壁密封地连接到生物药物组件中的连接器（1）的管状喷嘴（9）的联接装置，所述联接装置包括连接器（1），该连接器包括管状喷嘴 9），管道的一端可以沿其轴线A插入;多个柔性突片（3），其从联接体的中间区域（7）延伸到喷嘴的自由端（1a）， 邻接夹具（16），连接接口（6），可在非操作位置和操作位置之间轴向移动的单独的环（2），用于覆盖柔性突片（3），以便径向向内推动以便按压 管道处于工作位置的喷嘴上，当环（2）处于操作位置时，突出部基本上平行于轴线（A）延伸。