公开(公告)号：US10046117B2

公开(公告)日：2018-08-14

申请号：US14782742

申请日：2014-04-08

申请人： SANOFI

发明人： Bjorn Wilden ,  Stefan Bayer ,  Philipp Zeitz ,  Wolfgang Pelzer

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： Drive mechanism for a drug delivery device is disclosed. The drive mechanism includes an elongated housing extending in an axial direction. It includes a piston rod that operably engages with a piston of a cartridge to displace the piston in an axial distal direction. It includes a first dose indicating member that is rotatably supported on a longitudinal axis. It includes a second dose indicating member axially adjacent to the first dose indicating member and rotatably supported on the longitudinal axis. It includes a dose setting sleeve extending in an axial direction, rotatably engaged with the first dose indicating member and axially extending through the first dose indicating member to rotatably engage with the second dose indicating member.

公开(公告)号：US10105493B2

公开(公告)日：2018-10-23

申请号：US14783535

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Wolfgang Pelzer ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a drive wheel (110) axially fixed to the housing (20), engaged with the piston rod (160) and rotatable relative to the housing (20) for driving the piston rod (160) in distal direction (1), a drive sleeve (30) axially displaceable relative to the drive wheel (110) to rotatably engage with the drive wheel (110) in a distal dose dispensing position and to disengage from the drive wheel (110) in a proximal dose setting position, wherein the drive sleeve (30) is rotatably secured to the housing (20) in the proximal dose setting position by means of a ratchet member (32).

公开(公告)号：US20160045666A1

公开(公告)日：2016-02-18

申请号：US14782742

申请日：2014-04-08

申请人： SANOFI

发明人： Bjorn Wilden ,  Stefan Bayer ,  Philipp Zeitz ,  Wolfgang Pelzer

IPC分类号： A61M5/315

CPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31511 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/31583 ,  A61M2005/3126 ,  A61M2205/581 ,  A61M2205/582

摘要： The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises:—an elongated housing (20) extending in an axial direction (1, 2),—a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1),—a first dose indicating member (81) rotatably supported on a longitudinal axis (4),—a second dose indicating member (82) axially adjacent to the first dose indicating member (81) and rotatably supported on the longitudinal axis (4),—a dose setting sleeve (50) extending in axial direction (1, 2), rotatably engaged with the first dose indicating member (81) and axially extending through the first dose indicating member (81) to rotatably engage with the second dose indicating member (82).

摘要翻译： 本发明涉及一种用于分配药物剂量的药物输送装置的驱动机构，以及相应的药物输送装置，其中驱动机构包括： - 沿轴向方向（1）延伸的细长壳体（20） ，2）， - 活塞杆（160），其可与所述药筒（12）的活塞（14）可操作地接合以沿轴向远端方向（1）移动所述活塞（14）， - 第一剂量指示构件（81） 可旋转地支撑在纵向轴线（4）上， - 第二剂量指示构件（82），其轴向地邻近第一剂量指示构件（81）并且可旋转地支撑在纵向轴线（4）上;剂量设定套筒（50） 沿轴向方向（1,2），与第一剂量指示部件（81）可旋转地接合并且轴向延伸通过第一剂量指示部件（81）以与第二剂量指示部件（82）可旋转地接合。

公开(公告)号：US10420893B2

公开(公告)日：2019-09-24

申请号：US14916836

申请日：2014-09-08

申请人： Sanofi

发明人： Stefan Bayer ,  Philippe Blank ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315 ,  A61M5/24 ,  A61M5/28

摘要： A drug delivery device for dispensing of a dose of a medicament includes an elongated body extending in an axial direction, a cartridge holder to accommodate a cartridge at least partially filled with the medicament and having an axially displaceable piston, and a piston rod to operably engage with the piston of the cartridge to displace the piston in axial distal direction. The drug delivery device further includes a coupling member connected with the cartridge holder and being axially displaceably arranged in the body for retracting the cartridge holder into the body during setting of a dose.

公开(公告)号：US20160193421A1

公开(公告)日：2016-07-07

申请号：US14916836

申请日：2014-09-08

申请人： SANOFI

发明人： Stefan Bayer ,  Philippe Blank ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315

摘要： The present invention relates a drug delivery device for dispensing of a dose of a medicament, comprising: an elongated body (20) extending in an axial direction (1, 2), a cartridge holder (13) to accommodate a cartridge (12) at least partially filled with the medicament and having an axially displaceable piston (14), a piston rod (110) to operably engage with the piston (14) of the cartridge (12) to displace the piston (14) in axial distal direction (1), a coupling member (100) connected with the cartridge holder (13) and being axially displaceably arranged in the body (20) for retracting the cartridge holder (13) into the body (20) during setting of a dose.

摘要翻译： 本发明涉及一种用于分配药物剂量的药物递送装置，包括：沿轴向方向（1,2）延伸的细长体（20），用于容纳盒（12）的药筒保持器（13） 至少部分地填充有药物并且具有可轴向移动的活塞（14），活塞杆（110），其与所述药筒（12）的活塞（14）可操作地接合，以使所述活塞（14）在轴向远端方向（1 ），与所述盒保持器（13）连接并且在所述主体（20）中轴向移位地布置以用于在设定剂量期间将所述盒保持器（13）缩回到所述主体（20）中的联接构件（100）。

公开(公告)号：US10668223B2

公开(公告)日：2020-06-02

申请号：US14916834

申请日：2014-09-08

申请人： Sanofi

发明人： Stefan Bayer ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： A dose indicating mechanism for a drug delivery device for displaying of a dose of a medicament to be dispensed by the drug delivery device includes an elongated housing extending in an axial direction and having at least a first window and a second window that are spaced apart from each other in axial direction. The dose indicating mechanism further includes a dose indicating sleeve movably disposed in the housing and having at least one dose indication coinciding with the first window to display the size of a dose actually set, and an indicator operably engaged with the dose indicating sleeve and axially displaceable relative to the housing to coincide with the second window for indicating an operational status of the dose indicating mechanism.

公开(公告)号：US10420896B2

公开(公告)日：2019-09-24

申请号：US14916818

申请日：2014-09-08

申请人： Sanofi

发明人： Stefan Bayer ,  Wolfgang Pelzer ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/24

摘要： A drive mechanism of a drug delivery device for dispensing of a dose of a medicament, includes an elongated housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in axial distal direction, a drive sleeve rotatably supported in the housing at least in a dose incrementing direction against the action of a spring element, and a ratchet mechanism to rotatably fix the drive sleeve relative to the housing. A first ratchet body has a first and a second ratchet element to alternately engage with a toothed profile of a second ratchet body. One of the first and second ratchet bodies is operably engaged with the housing and wherein the other one of the first and second ratchet bodies is operably engaged with the drive sleeve.

公开(公告)号：US20160045667A1

公开(公告)日：2016-02-18

申请号：US14783010

申请日：2014-04-08

申请人： SANOFI

发明人： Björn Wilden ,  Stefan Bayer ,  Philipp Zeitz ,  Wolfgang Pelzer

IPC分类号： A61M5/315

CPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31511 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M2205/581

摘要： The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a dose setting member (120; 220) rotatably arranged at a proximal end of the housing (20) for setting of a dose, a base member (60; 260) having a proximally extending shaft portion (61; 261) at least partially enclosed by the dose setting member (120; 220), a last dose limiting member (140; 240) radially disposed between the dose setting member (120; 220) and the base member (60; 260) and having at least one radial stop (143; 243a, 243b) to limit a rotational displacement of the dose setting member (120; 220) relative to the base member (60; 260), wherein the last dose limiting member (140; 240) is rotatably locked but axially displaceable to one of the base member (60; 260) and the dose setting member (120; 220) and wherein the last dose limiting member (140; 240) is threadedly engaged with the other one of the base member (60; 260) and the dose setting member (120; 220).

摘要翻译： 本发明涉及用于分配药物剂量的药物输送装置的驱动机构，该机构包括：沿轴向方向（1,2）延伸的细长壳体（20），活塞杆（160）至 与柱塞（12）的活塞（14）可操作地接合以沿轴向远端方向（1）移动活塞（14）;剂量设定构件（120; 220），可旋转地布置在壳体（20）的近端处， 用于设定剂量的基部构件（60; 260）具有至少部分地由剂量设定构件（120; 220）封闭的近端延伸的轴部分（61; 261），最后剂量限制构件（140,240） 径向地设置在剂量设定部件（120; 220）和基部部件（60,260）之间并具有至少一个径向止动件（143; 243a，243b），以限制剂量设定部件（120; 220）的旋转位移， 相对于基部构件（60; 260），其中最后的剂量限制构件（140,240）可旋转地锁定，但可轴向移动到开 （60; 260）和所述剂量设定构件（120; 220），并且其中所述最后剂量限制构件（140; 240）与所述基座构件（60,260）和所述剂量设定构件（120; 220）中的另一个螺纹接合; 。

公开(公告)号：US10143805B2

公开(公告)日：2018-12-04

申请号：US14783010

申请日：2014-04-08

申请人： SANOFI

发明人： Björn Wilden ,  Stefan Bayer ,  Philipp Zeitz ,  Wolfgang Pelzer

IPC分类号： A61M5/315 ,  A61M5/20

摘要： The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: an elongated housing (20) extending in an axial direction (1, 2), a piston rod (160) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in axial distal direction (1), a dose setting member (120; 220) rotatably arranged at a proximal end of the housing (20) for setting of a dose, a base member (60; 260) having a proximally extending shaft portion (61; 261) at least partially enclosed by the dose setting member (120; 220), a last dose limiting member (140; 240) radially disposed between the dose setting member (120; 220) and the base member (60; 260) and having at least one radial stop (143; 243a, 243b) to limit a rotational displacement of the dose setting member (120; 220) relative to the base member (60; 260), wherein the last dose limiting member (140; 240) is rotatably locked but axially displaceable to one of the base member (60; 260) and the dose setting member (120; 220) and wherein the last dose limiting member (140; 240) is threadedly engaged with the other one of the base member (60; 260) and the dose setting member (120; 220).

公开(公告)号：US20160193425A1

公开(公告)日：2016-07-07

申请号：US14916834

申请日：2014-09-08

申请人： SANOFI

发明人： Stefan Bayer ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden ,  Philipp Zeitz

IPC分类号： A61M5/315

摘要： The present invention relates to a dose indicating mechanism for a drug delivery device for displaying of a dose of a medicament to be dispensed by the drug delivery device, the dose indicating mechanism comprising: an elongated housing (212) extending in an axial direction (1, 2) and having at least a first window (225) and a second window (235) that are spaced apart from each other in axial direction (1, 2), a dose indicating sleeve (200) movably disposed in the housing (212) and having at least one dose indication (204) coinciding with the first window (225) to display the size of a dose actually set, an indicator (206) operably engaged with the dose indicating sleeve (200) and axially displaceable relative to the housing (212) to coincide with the second window (235) for indicating an operational status of the dose indicating mechanism.

摘要翻译： 本发明涉及药物递送装置的剂量指示机构，用于显示由药物递送装置分配的药物的剂量，剂量指示机构包括：沿轴向方向（1）延伸的细长壳体（212） ，2）并且具有在轴向方向（1,2）上彼此间隔开的至少第一窗口（225）和第二窗口（235），剂量指示套筒（200）可移动地设置在所述壳体（212）中 并且具有与第一窗口（225）重合以显示实际设定的剂量的至少一个剂量指示（204），与剂量指示套筒（200）可操作地接合并相对于所述剂量指示套筒（200）可轴向移位的指示器（206） 壳体（212）与第二窗口（235）重合，用于指示剂量指示机构的操作状态。