公开(公告)号：US20220169674A1

公开(公告)日：2022-06-02

申请号：US17396464

申请日：2021-08-06

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

公开(公告)号：US20210369734A1

公开(公告)日：2021-12-02

申请号：US17401787

申请日：2021-08-13

Applicant: Sage Therapeutics, Inc.

Inventor： James J. Doherty

IPC: A61K31/569 ,  A61P25/28 ,  A61P25/22 ,  A61P25/08 ,  A61K9/00 ,  A61K31/568 ,  A61K31/5685 ,  A61K31/573 ,  A61K31/58

Abstract: Compounds, compositions, and methods for treating injuries caused by exposure to chemical warfare and similar agents are described herein.

公开(公告)号：US20240252514A1

公开(公告)日：2024-08-01

申请号：US18289550

申请日：2022-05-04

Applicant: SAGE THERAPEUTICS, INC.

Inventor： James J. Doherty ,  Michael C. Quirk ,  Aaron Michael Koenig ,  Jason Karl Johannesen

IPC: A61K31/575 ,  A61P25/16 ,  A61P25/28

CPC classification number: A61K31/575 ,  A61P25/16 ,  A61P25/28

Abstract: Provided herein are methods for improving working memory and/or executive function in a subject suffering from Parkinson's Disease, comprising administering to the subject a compound having the formula.

公开(公告)号：US20230218638A1

公开(公告)日：2023-07-13

申请号：US17947844

申请日：2022-09-19

Applicant: SAGE THERAPEUTICS, INC.

Inventor： Michael C. Quirk ,  James J. Doherty ,  Gabriel Martinez Botella

IPC: A61K31/575 ,  A61K45/06 ,  A61K31/00 ,  A61K45/00

CPC classification number: A61K31/575 ,  A61K45/06 ,  A61K31/00 ,  A61K45/00

Abstract: Methods for treating a subject suffering from a sterol synthesis disorder or a sterol deficiency disorder, e.g., Smith-Lemli-Opitz syndrome, the method comprising administering to the subject an effective amount of an NMDA receptor modulating compound, are provided.

公开(公告)号：US20220323462A1

公开(公告)日：2022-10-13

申请号：US17843031

申请日：2022-06-17

Applicant: Sage Therapeutics, Inc.

Inventor： Stephen Jay Kanes ,  James J. Doherty ,  Handan Gunduz-Bruce ,  Jeffrey M. Jonas ,  Robert Alfonso Lasser

IPC: A61K31/58 ,  A61P25/24 ,  A61P25/28

Abstract: Provided herein are methods for treating depression, such as postpartum depression or major depressive disorder, in a subject in need thereof, comprising administering to the subject an effective amount of Compound 1 or a pharmaceutically acceptable salt thereof:

公开(公告)号：US20220110949A1

公开(公告)日：2022-04-14

申请号：US16647203

申请日：2018-09-14

Applicant: Sage Therapeutics, Inc.

Inventor： James J. Doherty ,  Stephen Jay Kanes ,  Jeffrey M. Jonas ,  Inderjit Kaul

IPC: A61K31/58 ,  A61P25/20

Abstract: Provided herein are methods for treating a sleep disorder, e.g., insomnia, in a subject, comprising administering to the subject an effective amount of a compound having the formula (Compound 1) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11236121B2

公开(公告)日：2022-02-01

申请号：US16326977

申请日：2017-08-23

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed herein are methods of making crystalline solid forms of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.

公开(公告)号：US20230399357A1

公开(公告)日：2023-12-14

申请号：US18455324

申请日：2023-08-24

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08

CPC classification number: C07J43/003 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08 ,  C07B2200/13

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I),




and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

公开(公告)号：US20210228596A1

公开(公告)日：2021-07-29

申请号：US16755307

申请日：2018-10-12

Applicant: SAGE THERAPEUTICS, INC. ,  TRUSTEES OF TUFTS COLLEGE

Inventor： Michael Andrew Ackley ,  James J. Doherty ,  Stephen James Moss ,  Manasa Lakshmi Parakala ,  Paul A. Davies

IPC: A61K31/57 ,  A61P25/00 ,  A61K45/06

Abstract: Provided herein are methods, therapeutic agents and composition for treating a CNS-related disorder.

公开(公告)号：US20200341000A1

公开(公告)日：2020-10-29

申请号：US16755303

申请日：2018-10-12

Applicant: SAGE THERAPEUTICS, INC. ,  TRUSTEES OF TUFTS COLLEGE

Inventor： Michael Andrew Ackley ,  James J. Doherty ,  Stephen James Moss ,  Manasa Lakshmi Parakala ,  Paul A. Davies

IPC: G01N33/68 ,  G01N33/50 ,  G01N33/94 ,  G01N33/74 ,  G01N27/40

Abstract: Provided herein are screening methods and systems for the identification and evaluation of candidate GABAergic modulators. These candidate agents or compounds are useful for treating or preventing CNS-related disorders.