公开(公告)号：US20190388670A1

公开(公告)日：2019-12-26

申请号：US16480810

申请日：2018-01-30

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Johannes DE BROUWER ,  Herwig JUSTER ,  Pieter Jan Antoon JANSSEN ,  Marco NEFS

IPC: A61M37/00 ,  B29C55/02 ,  B29C59/02

Abstract: A method of forming a microneedle array having alternating layers of material includes transforming a multilayer sheet by cutting, assembling and stretching steps to form a stretched, stacked multilayer sheet. The stretched, stacked multilayer sheet is cut, assembled and stretched to form a film, the film is heated, and at least a portion of the film is caused to be displaced into a plurality of recesses thereby forming a plurality of protrusions at a surface of the film.

公开(公告)号：US20190388669A1

公开(公告)日：2019-12-26

申请号：US16480801

申请日：2018-01-29

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Maria Dolores MARTINEZ CANOVAS ,  Mark Adrianus Johannes VAN DER MEE ,  Robert Dirk VAN DE GRAMPEL ,  Johannes DE BROUWER ,  Herwig JUSTER

IPC: A61M37/00 ,  C08L69/00 ,  C08L83/04 ,  C08K5/01 ,  C08L23/02 ,  C08K5/103 ,  B29C39/02 ,  B29C39/36

Abstract: A microneedle comprising a shaft has a proximal end and a distal end and, optionally, a capillary space within said shaft, said capillary space (i) connecting said proximal and distal ends or (ii) extending from the distal end of the shaft and connecting with one or more external openings positioned between the proximal end and distal end or (iii) performing the functions of both (i) and (ii). The microneedle includes a polymer mixture that includes (a) polycarbonate, (b) polycarbonate-polysiloxane copolymer and (c) mold release agent.

公开(公告)号：US20190381708A1

公开(公告)日：2019-12-19

申请号：US16481534

申请日：2018-01-31

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Johannes DE BROUWER ,  Herwig JUSTER ,  Kenneth Francis LAWSON

IPC: B29C45/00 ,  A61M37/00 ,  B29C45/26

Abstract: A mold assembly 100 for forming a microneedle array, wherein the mold assembly facilitates expulsion of trapped gasses from the molding system. The mold assembly may comprise a first mold portion 102 comprising a plurality of recesses 104 formed therein, a second mold portion 106 disposed adjacent the first mold portion, wherein a surface of the second mold portion and the plurality of recesses of the first mold portion define a mold cavity, a mold film insert 112 disposed within the mold cavity between the first mold portion and the second mold portion of the mold assembly, the mold film insert comprising a plurality of perforated layers 114, each of the perforated layers comprising a plurality of perforations.

公开(公告)号：US20200094033A1

公开(公告)日：2020-03-26

申请号：US16471957

申请日：2017-12-21

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Johannes DE BROUWER ,  Herwig JUSTER

IPC: A61M37/00 ,  B29C43/22 ,  B29C33/42

Abstract: A method of forming a microneedle array comprising disposing a first curved laminate 100 adjacent an embossing roll 101. The laminate comprises a body having a first longitudinal side and a second longitudinal side extending from a curved base. The first longitudinal side comprises a plurality of recesses 111 disposed adjacent a periphery of the first longitudinal side. At least a second curved laminate 105 is disposed adjacent the embossing roll, defining a plurality of cavities 208 there between. A material is extruded at one or more of the first and second curved laminates. At least a portion of the embossing roll is heated at a point of contact between the material and one or more of the first and second curved laminates. The material is caused to move into the plurality of cavities forming a plurality of projections at a surface of the material and the material is demolded.

公开(公告)号：US20190381299A1

公开(公告)日：2019-12-19

申请号：US16481526

申请日：2018-01-31

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Johannes DE BROUWER ,  Herwig JUSTER

IPC: A61M37/00 ,  B29C43/46 ,  B29C43/52

Abstract: A mold assembly for forming a microneedle array via variothermal extrusion at a laser-drilled mold.