公开(公告)号：US4517211A

公开(公告)日：1985-05-14

申请号：US462193

申请日：1983-01-31

申请人： Roland Haraldsson ,  Jan Bengtsson ,  Claes Friberg

发明人： Roland Haraldsson ,  Jan Bengtsson ,  Claes Friberg

IPC分类号： A23B7/04 ,  A23L19/12 ,  A23L1/216

CPC分类号： A23B7/0441 ,  A23L19/13

摘要： A method for the production of concentrated, frozen puree, especially potato puree, in which method the potatoes are first washed, peeled, cut into pieces, blanched, cooled and dewatered. The potatoes thus processed are then dried to reduce their weight by 40-60%, whereupon the potatoes are steamed and then mashed, frozen and crushed. By drying the potatoes before they are steamed, a final product of higher quality is obtained, while at the same time chemical additives, such as antioxidants, consistency agents etc., are rendered superfluous.

摘要翻译： 一种生产浓缩，冷冻泥浆，特别是马铃薯泥的方法，首先将土豆洗涤，去皮，切成块，漂白，冷却和脱水。 然后将如此处理的马铃薯干燥以将其重量减少40-60％，然后将马铃薯蒸，然后捣碎，冷冻并粉碎。 通过在蒸煮之前将马铃薯干燥，可以获得更高品质的最终产品，同时使化学添加剂如抗氧化剂，稠度剂等变得多余。

公开(公告)号：US20050063911A1

公开(公告)日：2005-03-24

申请号：US10870945

申请日：2004-06-21

申请人： Thomas Nilsson ,  Mattias Myrman ,  Claes Friberg ,  Sven Calander

发明人： Thomas Nilsson ,  Mattias Myrman ,  Claes Friberg ,  Sven Calander

IPC分类号： A61J1/00 ,  A61K20060101 ,  A61K9/14 ,  A61K45/06 ,  A61L9/04 ,  A61M15/00 ,  A61P11/06 ,  A61P11/08

CPC分类号： A61K9/0075

摘要： The present invention discloses pharmaceutical dry powder combined doses for the administration by inhalation of metered dry powder combined doses of finely divided dry medication powders. Formoterol and an anticholinergic agent are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally suitable quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the delivered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments, whereby a desired therapeutic or treating effect to the user is achieved.

摘要翻译： 本发明公开了用于通过吸入计量干粉末组合剂量的细碎干药物粉末施用的药物干粉组合剂量。 选择福莫特罗和抗胆碱剂是用于形成组合剂量的药物。 制备计量的干粉药物组合剂量，其包含分别计量的每种药物合适量的定量沉积物，其中计量沉积物的总量构成组合剂量的计量量的粉末，并且药物组合剂量被引入 适合的吸入器装置，用于在用户单次吸入过程中大致同时或顺序递送药物组合剂量，使得每一个递送的药物组合剂量由高比例的 选择的药物或药物，从而实现对用户的期望的治疗或治疗效果。

公开(公告)号：USD454781S1

公开(公告)日：2002-03-26

申请号：US29139836

申请日：2001-04-06

申请人： Christian Assargren ,  Claes Friberg

设计人： Christian Assargren ,  Claes Friberg

公开(公告)号：US07069963B2

公开(公告)日：2006-07-04

申请号：US10777682

申请日：2004-02-13

申请人： Claes Friberg ,  Lars Kax

发明人： Claes Friberg ,  Lars Kax

IPC分类号： B65B1/04

CPC分类号： A61M15/0045 ,  A61M15/005 ,  A61M2202/064 ,  G01F11/24

摘要： The invention discloses a method and a tool for exact metering and volumetric filling of finely divided dry powder medicament doses into preformed containers, whereby the doses and containers are adapted for administration by inhalation using a dry powder inhaler (DPI). A filling tool illustrating the invention includes at least one receptacle (10). The shape and size of a receptacle may vary depending on the size and mass of the powder load to be metered. A stretched woven filter (106) is positioned between the second opening of the receptacle (10) and a suction nozzle (13), using flexible seals at joints to stop air and powder leakage. The shape may be circular or elliptical, the wideness and depth, i.e. the volume, is adapted to the intended load and the method of filling and unloading.

摘要翻译： 本发明公开了一种用于将精细分散的干粉药物剂量精确计量和体积填充到预成型容器中的方法和工具，由此剂量和容器适于使用干粉吸入器（DPI）通过吸入给药。 示出本发明的填充工具包括至少一个容器（10）。 容器的形状和尺寸可以根据要计量的粉末负载的尺寸和质量而变化。 拉伸的编织过滤器（106）位于容器（10）的第二开口和吸嘴（13）之间，在接头处使用柔性密封件来阻止空气和粉末泄漏。 形状可以是圆形或椭圆形，宽度和深度（即体积）适合于预期的载荷和填充和卸载的方法。

公开(公告)号：US07431916B2

公开(公告)日：2008-10-07

申请号：US10603819

申请日：2003-06-26

申请人： Thomas Nilsson ,  Mattias Myrman ,  Claes Friberg ,  Sven Calander

发明人： Thomas Nilsson ,  Mattias Myrman ,  Claes Friberg ,  Sven Calander

IPC分类号： A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K31/46 ,  A61K31/56 ,  A61K47/28

CPC分类号： A61M15/0045 ,  A61K9/0075 ,  A61M15/0003 ,  A61M15/0051 ,  A61M2202/064 ,  Y10S514/826

摘要： A method of administering a metered dry powder combined dose of finely divided dry medication powders is disclosed, wherein said method comprises providing a relative motion between a nozzle of a dry powder inhaler and a dose bed carrying said combined dose of finely divided dry medication powder intended for delivery by the dry powder inhaler, the combined dose comprises metered quantities of at least two medicaments separately deposited on the dose bed, the relative motion causing the nozzle to pass over the combined dose for a simultaneous or sequential delivery of the medicaments during the course of a single suction of air.

摘要翻译： 公开了一种施用计量干粉末组合剂量的细碎干药粉的方法，其中所述方法包括提供干粉吸入器的喷嘴与携带所述组合剂量的细碎干药粉的剂量床之间的相对运动 为了通过干粉吸入器输送，组合剂量包括计量的至少两种药物，分别沉积在剂量床上，相对运动导致喷嘴通过组合剂量以在该过程中同时或顺序递送药物 单吸空气。

公开(公告)号：US20080202630A1

公开(公告)日：2008-08-28

申请号：US10588214

申请日：2005-02-08

申请人： Lars Kax ,  Claes Friberg

发明人： Lars Kax ,  Claes Friberg

IPC分类号： B65B1/36

CPC分类号： A61M15/0045 ,  A61M15/005 ,  A61M2202/064 ,  G01F11/24

摘要： A method and an apparatus for exact metering and volumetric filling of dry powder medicament doses into preformed containers, which are adapted for administration by a dry powder inhaler. The filling apparatus includes at least a bulk powder source, a feeding chamber, and a receptacle providing the volume for a specified load mass of dry powder. The bulk powder source releases a portion of powder discontinuously to the feeding chamber, but is disconnected from the feeding chamber and receptacle during the filling operation. The filling apparatus further presents a plane surface in contact with the movable feeding chamber and provides a hard-wearing, low friction coating for reducing dynamic friction and powder retention.

摘要翻译： 用于将干粉药剂剂量精确计量和体积填充到预成型容器中的方法和装置，其适于通过干粉吸入器施用。 填充装置至少包括散装粉末源，进料室和提供用于特定负载量干粉的体积的容器。 散装粉末源将一部分粉末不连续地释放到进料室，但在填充操作期间与进料室和容器断开连接。 填充装置还具有与可移动进料室接触的平面，并提供耐磨耗低的摩擦涂层，以减少动摩擦和粉末保持。

公开(公告)号：US20050173552A1

公开(公告)日：2005-08-11

申请号：US10777682

申请日：2004-02-13

申请人： Claes Friberg ,  Lars Kax

发明人： Claes Friberg ,  Lars Kax

IPC分类号： A61M15/00 ,  A62C5/02 ,  B05B7/04 ,  B05D1/00 ,  B65B20060101 ,  B65B1/36 ,  F23D11/36 ,  F23D11/40 ,  G01F11/24

CPC分类号： A61M15/0045 ,  A61M15/005 ,  A61M2202/064 ,  G01F11/24

摘要： The invention discloses a method and a tool for exact metering and volumetric filling of finely divided dry powder medicament doses into preformed containers, whereby the doses and containers are adapted for administration by inhalation using a dry powder inhaler (DPI). A filling tool illustrating the invention includes at least one receptacle (10). The shape and size of a receptacle may vary depending on the size and mass of the powder load to be metered. A stretched woven filter (106) is positioned between the second opening of the receptacle (10) and a suction nozzle (13), using flexible seals at joints to stop air and powder leakage. The shape may be circular or elliptical, the wideness and depth, i.e. the volume, is adapted to the intended load and the method of filling and unloading.

摘要翻译： 本发明公开了一种用于将精细分散的干粉药物剂量精确计量和体积填充到预成型容器中的方法和工具，由此剂量和容器适于使用干粉吸入器（DPI）通过吸入给药。 示出本发明的填充工具包括至少一个容器（10）。 容器的形状和尺寸可以根据要计量的粉末负载的尺寸和质量而变化。 拉伸的编织过滤器（106）位于容器（10）的第二开口和吸嘴（13）之间，在接头处使用柔性密封件来阻止空气和粉末泄漏。 形状可以是圆形或椭圆形，宽度和深度（即体积）适合于预期的载荷和填充和卸载的方法。

公开(公告)号：US20050042175A1

公开(公告)日：2005-02-24

申请号：US10870909

申请日：2004-06-21

申请人： Thomas Nilsson ,  Mattias Myrman ,  Claes Friberg ,  Sven Calander

发明人： Thomas Nilsson ,  Mattias Myrman ,  Claes Friberg ,  Sven Calander

IPC分类号： A61J3/00 ,  A61K9/14 ,  A61K31/167 ,  A61K31/58 ,  A61K45/06 ,  A61L9/04 ,  A61M20060101 ,  A61P11/06 ,  A61P11/08

CPC分类号： A61K9/0075 ,  A61K45/06

摘要： The present invention discloses pharmaceutical dry powder combined doses for administration by inhalation of metered dry powder combined doses of finely divided dry medication doses. Formoterol and budesonide are selected medicaments for forming the combined doses. Metered dry powder medicinal combined doses comprising separately metered deposits of medicinally effective quantities of each of the selected medicaments are prepared, in which the sum of the metered deposits constitutes the metered quantities of powder of the combined doses and the medicinal combined doses are introduced into an adapted inhaler device for a generally simultaneous or sequential prolonged delivery of the medicinal combined doses during the course of a single inhalation by a user, such that each one of the administered medicinal combined doses is composed of a high proportion of de-aggregated fine particles of the selected medicament or medicaments and directed to a selected location in the lungs of a user.

摘要翻译： 本发明公开了药物干粉组合剂量，用于通过吸入计量干粉末组合剂量的细分干药剂量给药。 选择福莫特罗和布地奈德是用于形成组合剂量的药物。 制备计量的干粉药物组合剂量，其包含分别计量的药物有效量的每种选定药物的定量沉积物，其中定量沉积物的总量构成组合剂量的计量量的粉末，并且药物组合剂量被引入 适合的吸入器装置，用于在使用者的单次吸入过程中通常同时或顺序地延长药物组合剂量的递送，使得所施用的药物组合剂量中的每一个由高比例的 所选择的药物或药物并且被引导到使用者的肺中的选定位置。

公开(公告)号：US20060239933A1

公开(公告)日：2006-10-26

申请号：US11272859

申请日：2005-11-15

申请人： Thomas Nilsson ,  Sven Calander ,  Alf Niemi ,  Claes Friberg ,  Lars Kax ,  Mattias Myrman

发明人： Thomas Nilsson ,  Sven Calander ,  Alf Niemi ,  Claes Friberg ,  Lars Kax ,  Mattias Myrman

IPC分类号： A61K9/14 ,  A61L9/04 ,  A61K38/28

CPC分类号： A61K9/0075 ,  A61K38/26

摘要： A medical product is disclosed. The medical product contains an accurately metered dose of at least one GLP medicament intended for pulmonary inhalation put into a moisture-tight, high barrier seal container. The medical product optionally also contains a dose of insulin. The container is adapted for application into a dry powder inhaler. The dose loaded in the container is intended for a prolonged delivery by inhalation to the deep lung where the active ingredients are absorbed into the system. Optionally the medical product also may comprise at least one biologically acceptable excipient.

摘要翻译： 披露了医疗产品。 医疗产品包含准确计量剂量的至少一种用于肺部吸入的GLP药物放入防潮密封的高屏障密封容器中。 医疗产品任选还含有一定剂量的胰岛素。 容器适用于干粉吸入器。 装载在容器中的剂量旨在通过吸入长时间地输送到深肺，其中活性成分被吸收到系统中。 任选地，医疗产品还可以包含至少一种生物可接受的赋形剂。

公开(公告)号：US20060067911A1

公开(公告)日：2006-03-30

申请号：US11111888

申请日：2005-04-22

申请人： Thomas Nilsson ,  Claes Friberg ,  Lars Kax ,  Alf Niemi ,  Mattias Myrman ,  Sven Calander

发明人： Thomas Nilsson ,  Claes Friberg ,  Lars Kax ,  Alf Niemi ,  Mattias Myrman ,  Sven Calander

IPC分类号： A61K38/28 ,  A61K38/22 ,  A61K38/19

CPC分类号： A61K9/0075 ,  A61K38/00 ,  A61M15/0045 ,  A61M15/0051 ,  A61M2202/064

摘要： The invention discloses a metered medication dose of a dry powder protein medicament, particularly a peptide medicament, intended for inhalation by use of an adapted dry powder inhaler. An active peptide agent is presented in a pure, natural, crystalline, micronized, dry powder form. A dose comprises at least one such peptide powder and may optionally comprise at least one biologically acceptable excipient in dry powder form. The dose does not include any substances that are intended to change one, some or all properties of the at least one peptide with an object of improving the stability or systemic absorption of the active peptide or peptides deposited.

摘要翻译： 本发明公开了一种计量药物剂量的干粉蛋白药物，特别是肽药物，其旨在通过使用适合的干粉吸入器吸入。 活性肽剂以纯的，天然的，结晶的，微粉化的干粉形式呈现。 剂量包含至少一种这样的肽粉末，并且可以任选地包含至少一种干粉形式的生物可接受的赋形剂。 剂量不包括旨在改变至少一种肽的一种，一些或所有性质的任何物质，其目的是改善沉积的活性肽或肽的稳定性或全身吸收。