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公开(公告)号：US06641817B1
公开(公告)日：2003-11-04
申请号：US09744942
申请日：2001-08-06
IPC分类号： A61K39245
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5154 , A61K2039/5254 , C12N2710/16643
摘要： An attenuated herpes virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell. The attenuated herpes virus and dentrictic cells infected with the virus are useful in immunotherapeutic methods of treating disease.
摘要翻译： 能够有效感染树突状细胞而不防止感染细胞内发生抗原加工的减毒疱疹病毒。 减毒的疱疹病毒和感染病毒的牙质细胞可用于治疗疾病的免疫治疗方法。
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公开(公告)号：US20050249707A1
公开(公告)日：2005-11-10
申请号：US11155688
申请日：2005-06-20
申请人： Robert Coffin , Benjamin Chain
发明人： Robert Coffin , Benjamin Chain
IPC分类号： C12N15/09 , A61K35/14 , A61K35/76 , A61K39/00 , A61K39/12 , A61K48/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/02 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/869 , C12R1/91 , C12R1/93
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5154 , A61K2039/5254 , C12N2710/16643
摘要： An attenuated herpes virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell. The attenuated herpes virus and dendritic cells infected with the virus are useful immunotherapeutic methods of treating disease.
摘要翻译： 能够有效感染树突状细胞而不防止感染细胞内发生抗原加工的减毒疱疹病毒。 感染病毒的减毒疱疹病毒和树突细胞是治疗疾病的有用的免疫治疗方法。
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3.发明申请Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies 失效嵌合肽作为免疫原，其抗体，以及使用嵌合肽或抗体进行免疫的方法公开(公告)号：US20060088548A1
公开(公告)日：2006-04-27
申请号：US09731899
申请日：2000-12-08
申请人： Benjamin Chain
发明人： Benjamin Chain
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/00 , A61K2039/64 , C07K14/4711 , C07K19/00 , C07K2319/00 , C07K2319/40 , C12N15/62 , Y02A50/412 , Y02A50/423
摘要： The invention provides a chimeric peptide or mixture of chimeric peptides that can be formulated as an immunizing composition and used in a method for immunization of a mammal against an internal peptide cleavage product derived from a precursor or mature protein, for which the peptide cleavage product and the precursor or mature protein are self molecules. The chimeric peptide or peptides have an end-specific B cell epitope from a naturally-occurring internal peptide cleavage product of a precursor or mature protein, as a free N- or C-terminus, fused with or without spacer residues to a T helper cell epitope derived from a living source different from that of the internal peptide cleavage product.
摘要翻译： 本发明提供嵌合肽或嵌合肽的混合物，其可以配制成免疫组合物，并且用于免疫哺乳动物免受衍生自前体或成熟蛋白质的内肽切割产物的方法，其中肽切割产物和 前体或成熟蛋白是自身分子。 嵌合肽或肽具有来自前体或成熟蛋白的天然存在的内肽切割产物的末端特异性B细胞表位，作为游离N-或C-末端，与或不与间隔子残基融合到T辅助细胞 衍生自不同于内肽裂解产物的活体源的表位。
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4.发明申请CHIMERIC PEPTIDES AS IMMUNOGENS, ANTIBODIES THERETO, AND METHODS FOR IMMUNIZATION USING CHIMERIC PEPTIDES OR ANTIBODIES 审中-公开作为免疫调节剂的抗体，抗体，以及使用重组肽或抗体进行免疫的方法公开(公告)号：US20110280879A1
公开(公告)日：2011-11-17
申请号：US12951836
申请日：2010-11-22
申请人： Benjamin Chain
发明人： Benjamin Chain
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/00 , A61K2039/64 , C07K14/4711 , C07K19/00 , C07K2319/00 , C07K2319/40 , C12N15/62 , Y02A50/412 , Y02A50/423
摘要： The invention provides a chimeric peptide or mixture of chimeric peptides that can be formulated as an immunizing composition and used in a method for immunization of a mammal against an internal peptide cleavage product derived from a precursor or mature protein, for which the peptide cleavage product and the precursor or mature protein are self molecules. The chimeric peptide or peptides have an end-specific B cell epitope from a naturally-occurring internal peptide cleavage product of a precursor or mature protein, as a free N- or C-terminus, fused with or without spacer residues to a T helper cell epitope derived from a living source different from that of the internal peptide cleavage product.
摘要翻译： 本发明提供嵌合肽或嵌合肽的混合物，其可以配制成免疫组合物，并且用于免疫哺乳动物免受衍生自前体或成熟蛋白质的内肽切割产物的方法，其中肽切割产物和 前体或成熟蛋白是自身分子。 嵌合肽或肽具有来自前体或成熟蛋白的天然存在的内肽切割产物的末端特异性B细胞表位，作为游离N-或C-末端，与或不与间隔子残基融合到T辅助细胞 衍生自不同于内肽裂解产物的活体源的表位。
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5.发明授权Chimeric peptides as immunogens, antibodies thereto, and methods for immunization using chimeric peptides or antibodies 失效嵌合肽作为免疫原，其抗体，以及使用嵌合肽或抗体进行免疫的方法公开(公告)号：US07901689B2
公开(公告)日：2011-03-08
申请号：US09731899
申请日：2000-12-08
申请人： Benjamin Chain
发明人： Benjamin Chain
CPC分类号： A61K39/0007 , A61K38/00 , A61K39/00 , A61K2039/64 , C07K14/4711 , C07K19/00 , C07K2319/00 , C07K2319/40 , C12N15/62 , Y02A50/412 , Y02A50/423
摘要： The invention provides a chimeric peptide or mixture of chimeric peptides that can be formulated as an immunizing composition and used in a method for immunization of a mammal against an internal peptide cleavage product derived from a precursor or mature protein, for which the peptide cleavage product and the precursor or mature protein are self molecules. The chimeric peptide or peptides have an end-specific B cell epitope from a naturally-occurring internal peptide cleavage product of a precursor or mature protein, as a free N- or C-terminus, fused with or without spacer residues to a T helper cell epitope derived from a living source different from that of the internal peptide cleavage product.
摘要翻译： 本发明提供嵌合肽或嵌合肽的混合物，其可以配制成免疫组合物，并且用于免疫哺乳动物免受衍生自前体或成熟蛋白质的内肽切割产物的方法，其中肽切割产物和 前体或成熟蛋白是自身分子。 嵌合肽或肽具有来自前体或成熟蛋白的天然存在的内肽切割产物的末端特异性B细胞表位，作为游离N-或C-末端，与或不与间隔子残基融合到T辅助细胞 衍生自不同于内肽裂解产物的活体源的表位。
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