公开(公告)号：US20240150728A1

公开(公告)日：2024-05-09

申请号：US18379644

申请日：2023-10-12

申请人： Resilience Government Services, Inc.

发明人： Perry NEWTON ,  Dalton BERRIE ,  Tyler GROW ,  Sheldon DOXILLY ,  Christopher J. MONTOYA ,  Sara Jane TERPENING ,  Eric VELA

IPC分类号： C12N7/00 ,  C12M1/12 ,  C12M1/34

CPC分类号： C12N7/00 ,  C12M25/18 ,  C12M41/12 ,  C12M41/26 ,  C12M41/34 ,  C12M41/36 ,  C12N2760/20234 ,  C12N2760/20243 ,  C12N2760/20251

摘要： The invention relates to a method of increasing the yield of virus, virus particles, or viral vectors from host cells in a bioreactor. The invention provides a reproducible and robust method and system of determining and controlling the optimal time of infection of host cells using a correlation of process air parameters including Air flow, O2 flow, and respective trends thereof resulting in increased virus yield.