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公开(公告)号：US10988743B2
公开(公告)日：2021-04-27
申请号：US16079896
申请日：2017-02-24
发明人： Masayuki Inui , Kazumi Hiraga , Masako Suda , Takeshi Kubota
摘要： Provided is a microorganism that is capable of efficiently producing para-aminobenzoic acid (4-ABA) or a salt thereof, using saccharides as raw materials, and a method for efficiently producing 4-ABA or a salt thereof by using this microorganism.
A transformant obtained by introducing, into a coryneform bacterium, a gene that encodes 4-amino-4-deoxychorismate lyase, a gene that encodes a para-aminobenzoate synthase component I, and a gene that encodes a para-aminobenzoate synthase component II, is capable of efficiently producing 4-ABA or a salt thereof from saccharides.-
公开(公告)号：US10961526B2
公开(公告)日：2021-03-30
申请号：US16089567
申请日：2017-02-24
发明人： Masayuki Inui , Kazumi Hiraga , Masako Suda , Takahisa Kogure
摘要： Provided is a microorganism that is able to efficiently produce protocatechuic acid or a salt thereof by using a saccharide as a raw material, and a method of efficiently producing protocatechuic acid or a salt thereof by using the microorganism. Provided is a transformant having protocatechuic acid producing ability, subjected to modifications of enhancement of 3-dehydroshikimate dehydratase activity; enhancement of chorismate pyruvate lyase activity; and enhancement of 4-hydroxybenzoate hydroxylase activity. Also provided is a method of producing protocatechuic acid or a salt thereof, including the step of culturing the transformant in a reaction solution containing a saccharide so as to cause the transformant to produce protocatechuic acid or a salt thereof.
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公开(公告)号：US20220025412A1
公开(公告)日：2022-01-27
申请号：US17414021
申请日：2019-12-19
发明人： Masayuki Inui , Kazumi Hiraga , Masako Suda , Masayoshi Hashizume , Junya Ishida
摘要： Provided is a microorganism that is able to produce 2-phenylethanol at a high concentration, and a method of efficiently producing 2-phenylethanol by using a saccharide as a raw material.
Provided is a coryneform bacterium transformant in which a shikimate pathway is activated, and further, a gene that encodes an enzyme having phenylpyruvate decarboxylase activity is introduced in such a manner that the gene can be expressed.
Also provided is a 2-phenylethanol producing method that includes causing the coryneform bacterium transformant according to the present disclosure to react in water containing a saccharide.-
4.发明授权公开(公告)号：US10208313B2
公开(公告)日：2019-02-19
申请号：US15503813
申请日：2015-08-20
发明人： Masayuki Inui , Masako Suda , Kazumi Hiraga , Takahisa Kogure
摘要： A coryneform bacterium transformant engineered by the following (A) to (D): (A) enhancement of 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase activity; (B) prevention, inhibition, or reduction of intracellular sugar uptake mediated by phosphotransferase system (PTS); (C) enhancement of intracellular sugar uptake activity mediated by a sugar transporter different from phosphotransferase system and enhancement of glucokinase activity; and (D) enhancement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity is capable of efficiently producing shikimic acid or the like from a sugar.
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5.发明授权公开(公告)号：US11359217B2
公开(公告)日：2022-06-14
申请号：US17051514
申请日：2019-02-18
发明人： Masayuki Inui , Kazumi Hiraga , Masako Suda , Takeshi Kubota
摘要： Provided is a transformant of a microorganism that has improved catechol productivity.
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公开(公告)号：US09803223B2
公开(公告)日：2017-10-31
申请号：US14782893
申请日：2014-03-04
CPC分类号： C12P13/001 , C12N1/20 , C12N9/88 , C12Y401/01024
摘要： An objective of the present invention is to provide a microorganism capable of efficiently producing aniline from aminobenzoic acid, and a process for efficiently producing aniline from aminobenzoic acid. To achieve the objective, provided is an aniline-producing transformant constructed by introducing a gene which encodes an enzyme having aminobenzoate decarboxylase activity into a coryneform bacterium as a host, characterized in that the enzyme having aminobenzoate decarboxylase activity is composed of an amino acid sequence which is the same as that represented by SEQ ID NO: 2 except for having a mutation of at least proline (P) at position 309 from the N terminus.
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