公开(公告)号：US20230348456A1

公开(公告)日：2023-11-02

申请号：US18140302

申请日：2023-04-27

Applicant: Repare Therapeutics Inc.

Inventor： Janek SZYCHOWSKI ,  Bingcan LIU ,  Evelyne DIETRICH ,  Alexander PERRYMAN ,  Sheldon N. CRANE ,  Vouy Linh TRUONG ,  Abbas ABDOLI ,  Alexanne BOUCHARD

IPC: C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D491/107 ,  C07D209/46 ,  C07D493/08 ,  C07D411/14

CPC classification number: C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D491/107 ,  C07D209/46 ,  C07D493/08 ,  C07D411/14

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

公开(公告)号：US20210277002A1

公开(公告)日：2021-09-09

申请号：US17245574

申请日：2021-04-30

Applicant: Repare Therapeutics Inc.

Inventor： Sheldon N. CRANE ,  Vouy Linh TRUONG ,  Abbas ABDOLI ,  Jean-François TRUCHON ,  Cameron BLACK ,  Stéphane DORICH ,  Lee FADER ,  Stéphanie LANOIX ,  Paul JONES ,  Miguel ST-ONGE ,  Audrey PICARD ,  Cyrus M. LACBAY

IPC: C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of Ataxia-telangiectasia and RAD-3-related protein kinase (ATR). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

公开(公告)号：US20230122909A1

公开(公告)日：2023-04-20

申请号：US17937977

申请日：2022-10-04

Applicant: Repare Therapeutics Inc.

Inventor： Janek SZYCHOWSKI ,  Bingcan LIU ,  Evelyne DIETRICH ,  Frédéric VALLÉE ,  Alexander PERRYMAN ,  Jean-François TRUCHON ,  Robert PAPP ,  Patrick BEAULIEU ,  Vouy Linh TRUONG ,  Kaveh MATINKHOO ,  Sheldon N. CRANE

IPC: C07D487/04 ,  C07D471/04 ,  C07D209/12

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.