公开(公告)号：US20230122909A1

公开(公告)日：2023-04-20

申请号：US17937977

申请日：2022-10-04

Applicant: Repare Therapeutics Inc.

Inventor： Janek SZYCHOWSKI ,  Bingcan LIU ,  Evelyne DIETRICH ,  Frédéric VALLÉE ,  Alexander PERRYMAN ,  Jean-François TRUCHON ,  Robert PAPP ,  Patrick BEAULIEU ,  Vouy Linh TRUONG ,  Kaveh MATINKHOO ,  Sheldon N. CRANE

IPC: C07D487/04 ,  C07D471/04 ,  C07D209/12

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

公开(公告)号：US20230151014A1

公开(公告)日：2023-05-18

申请号：US17916760

申请日：2021-04-01

Applicant: Repare Therapeutics Inc.

Inventor： Janek SZYCHOWSKI ,  Bingcan LIU ,  Evelyne DIETRICH ,  Frédéric VALLÉE ,  Alexander PERRYMAN ,  Jean-François TRUCHON ,  Robert PAPP ,  Patrick BEAULIEU

IPC: C07D487/04 ,  C07D471/04 ,  C07D519/00 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00 ,  A61P35/00 ,  C07B2200/05

Abstract: Disclosed are compounds and pharmaceutically acceptable salts thereof that may be used in the treatment of subjects in need thereof. The compounds disclosed herein may be inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1). Also disclosed are pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and methods of their preparation and use.

公开(公告)号：US20230158022A1

公开(公告)日：2023-05-25

申请号：US17916773

申请日：2021-04-01

Applicant: Repare Therapeutics Inc. ,  Sinai Health System

Inventor： Daniel DUROCHER ,  Jordan YOUNG ,  Frank SICHERI ,  Janek SZYCHOWSKI ,  Bingcan LIU ,  Evelyne DIETRICH ,  Frédéric VALLÉE ,  Alexander PERRYMAN ,  Jean-François TRUCHON ,  Robert PAPP ,  Theresa ZHANG ,  Artur VELOSO ,  Jimmy FOURTOUNIS ,  Patrick BEAULIEU

IPC: A61K31/4985 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/506 ,  A61K31/541 ,  A61K31/55 ,  A61K31/501 ,  A61P35/00 ,  A61K31/444

CPC classification number: A61K31/4985 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/506 ,  A61K31/541 ,  A61K31/55 ,  A61K31/501 ,  A61P35/00 ,  A61K31/444

Abstract: Disclosed are methods of using inhibitors of tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1), e.g., in the treatment of subjects in need thereof.