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公开(公告)号：US20080118312A1
公开(公告)日：2008-05-22
申请号：US11940413
申请日：2007-11-15
Applicant: Reinhard Lihl , Michael Zimmermann , Andreas Hallady , Guenther Bock
Inventor： Reinhard Lihl , Michael Zimmermann , Andreas Hallady , Guenther Bock
IPC: B26D1/12
CPC classification number: G01N1/06 , Y10T83/7788 , Y10T83/8807 , Y10T407/1906
Abstract: An apparatus (1) for processing specimens (15), comprising an observation device (2), a specimen holder (3) for receiving the specimen (15) to be processed, and a tool holder (6), the tool holder (6) being pivotable in a plane normal to its longitudinal axis (L′) by means of a pivot arm (22), and being rotatable about its longitudinal axis (L′); furthermore a drive system for selectable execution of the pivoting of the pivot arm (22) is provided.
Abstract translation: 一种用于加工试样（15）的装置（1），包括观察装置（2），用于接收待加工的试样（15）的试样支架（3）和工具夹具（6），工具夹具 ）可以通过枢转臂（22）在垂直于其纵向轴线（L'）的平面中枢转，并且可围绕其纵向轴线（L'）旋转; 此外，提供了用于可选地执行枢转臂（22）的枢转的驱动系统。
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公开(公告)号：US20090183613A1
公开(公告)日：2009-07-23
申请号：US12337193
申请日：2008-12-17
Applicant: Reinhard Lihl , Michael Zimmermann
Inventor： Reinhard Lihl , Michael Zimmermann
CPC classification number: G01N1/06 , B26D1/00 , B26D1/105 , B26D1/1575 , G01N1/42 , Y10T83/222 , Y10T83/283 , Y10T83/6508 , Y10T83/6571
Abstract: A microtome system has a cryomicrotome with a sectioning device in which is provided a preparation holder and a knife edge that are guided past one another inside a working space during a sectioning operation, in order to produce thin sections of a preparation retained in the preparation holder. A micromanipulator is operable outside the working space. With the micromanipulator, a tool for retention of a specimen support is positioned proximate the knife edge during a sectioning operation in order to receive the sections that are produced, preferably for substantially stationary retention of the specimen support.
Abstract translation: 切片机系统具有冷冻切片机，其具有切片装置，在切片装置中设置有准备保持器和刀刃，其在切片操作期间在工作空间内相互引导，以便制备保留在制备保持架中的制剂的薄部分 。 微操纵器可在工作空间外操作。 使用显微操纵器，用于保持试样支架的工具在切割操作期间被定位在刀刃附近，以便接收所生产的部分，优选地基本上固定保持试样支架。
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3.发明授权Dewar vessel for automated cryosubstitution or low-temperature substitution, and apparatus for automated cryosubstitution or low-temperature substitution 有权用于自动冷冻置换或低温置换的杜瓦瓶，以及用于自动冷冻置换或低温替代的装置公开(公告)号：US07547416B2
公开(公告)日：2009-06-16
申请号：US11335104
申请日：2006-01-19
Applicant: Reinhard Lihl , Michael Zimmermann , Hubert Goll , Paul Wurzinger
Inventor： Reinhard Lihl , Michael Zimmermann , Hubert Goll , Paul Wurzinger
CPC classification number: G01N1/42 , A01N1/0257 , F17C2270/0509 , F25D3/10 , Y10T436/2525
Abstract: A Dewar vessel (1) for automated cryosubstitution or low-temperature substitution is disclosed. The invention further discloses an apparatus (10) for automated liquid transfer for cryosubstitution or low-temperature substitution. The apparatus (10) encompasses a container (50) that encompasses at least one specimen holder (2) and at least one reservoir holder (20); and wherein a movable transfer container (35) for automated exchange of at least one liquid (42) between the at least one specimen holder (2) and the at least one reservoir holder (20) is provided.
Abstract translation: 公开了用于自动冷冻置换或低温置换的杜瓦瓶（1）。 本发明还公开了一种用于冷冻置换或低温替代的自动化液体转移的装置（10）。 装置（10）包括容纳至少一个样本保持器（2）和至少一个储存器保持器（20）的容器（50）; 并且其中提供用于自动更换所述至少一个样本保持器（2）和所述至少一个储存器保持器（20）之间的至少一个液体（42）的可移动转移容器（35）。
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4.发明授权公开(公告)号：US08516909B2
公开(公告)日：2013-08-27
申请号：US12841240
申请日：2010-07-22
Applicant: Reinhard Lihl , Michael Zimmermann
Inventor： Reinhard Lihl , Michael Zimmermann
IPC: G01N1/42
CPC classification number: G01N1/42
Abstract: The present invention relates to a cryopreparation chamber (100) for preparing and manipulating a sample for electron microscopy, the cryopreparation chamber (100) being cooled by a primary cryogen, the cryopreparation chamber (100) including a first and a second chamber portion (101,102), the second chamber portion (102) being detachably placeable (101) on the first chamber portion (101), and moreover, the second chamber portion (102) being provided, in its outer wall (106), with an access port (107) through which a specimen holder (108) for an electron microscope can be inserted into the cryopreparation chamber (100). The present invention also relates to a cryopreparation device (200) which is suitable for cryopreparing a sample for an electron microscope and includes such a cryopreparation chamber (100).
Abstract translation: 本发明涉及一种用于制备和操纵用于电子显微镜的样品的冷冻制备腔室（100），所述冷冻制备腔室（100）由一级冷冻剂冷却，所述冷冻制备腔室（100）包括第一和第二腔室部分（101,102 ），第二室部分（102）可拆卸地放置在第一室部分（101）上，此外，第二室部分（102）在其外壁（106）中设置有进入端口 107），用于电子显微镜的样本保持器（108）可以通过其插入冷冻制备室100中。 本发明还涉及适用于冷冻制备用于电子显微镜的样品的冷冻制备装置（200），并且包括这种冷冻制备腔室（100）。
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公开(公告)号：US08113099B2
公开(公告)日：2012-02-14
申请号：US11940413
申请日：2007-11-15
Applicant: Reinhard Lihl , Michael Zimmermann , Andreas Hallady , Guenther Bock
Inventor： Reinhard Lihl , Michael Zimmermann , Andreas Hallady , Guenther Bock
IPC: B26D5/16
CPC classification number: G01N1/06 , Y10T83/7788 , Y10T83/8807 , Y10T407/1906
Abstract: An apparatus (1) for processing specimens (15), comprising an observation device (2), a specimen holder (3) for receiving the specimen (15) to be processed, and a tool holder (6), the tool holder (6) being pivotable in a plane normal to its longitudinal axis (L′) by a pivot arm (22), and being rotatable about its longitudinal axis (L′); furthermore a drive system for selectable execution of the pivoting of the pivot arm (22) is provided.
Abstract translation: 一种用于加工试样（15）的装置（1），包括观察装置（2），用于接收待加工的试样（15）的试样支架（3）和工具夹具（6），工具夹具 ）能够通过枢转臂（22）在垂直于其纵向轴线（L'）的平面中枢转，并且可围绕其纵向轴线（L'）旋转; 此外，提供了用于可选地执行枢转臂（22）的枢转的驱动系统。
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Patent Agency Ranking
公开(公告)号：US07232546B2
公开(公告)日：2007-06-19
申请号：US10100850
申请日：2002-03-18
Applicant: Reinhard Lihl , Guenther Bock , Ian Lamswood , Michael Zimmermann
Inventor： Reinhard Lihl , Guenther Bock , Ian Lamswood , Michael Zimmermann
IPC: G01N25/00
CPC classification number: G01N1/36 , G01N1/31 , Y10T436/11 , Y10T436/112499 , Y10T436/115831
Abstract: An apparatus (1) for tissue preparation for the tissue embedding, having a transport plate (15) that is surrounded by a housing (5). The housing defines an inner upper side (8a), a heating and cooling device (3), that is provided on the inner upper side (8a) of the housing (5) and a mechanic module (24) for turning the transport plate (15) and for raising and lowering the transport plate (15). The mechanic module (24) comprises a first motor (42) exclusively for turning the transport plate (15) around an axle (18) and a second motor (44) exclusively for raising and lowering the transport plate (15) in the direction of the axle (18).
Abstract translation: 一种用于组织包埋的组织制备的装置（1），具有由壳体（5）包围的传送板（15）。 壳体限定设置在壳体（5）的内侧上侧（8a）上的内部上侧（8a），加热和冷却装置（3）以及用于转动运输工具的机械模块（24） 板（15）并且用于升高和降低运输板（15）。 机械模块（24）包括专门用于使运输板（15）围绕轴（18）转动的第一马达（42）和专门用于沿运输板（15）的方向升高和降低运输板（15）的第二马达（44） 轴（18）。
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7.发明申请Dewar vessel for automated cryosubstitution or low-temperature substitution, and apparatus for automated cryosubstitution or low-temperature substitution 有权用于自动冷冻置换或低温置换的杜瓦瓶，以及用于自动冷冻置换或低温替代的装置公开(公告)号：US20060162653A1
公开(公告)日：2006-07-27
申请号：US11335104
申请日：2006-01-19
Applicant: Reinhard Lihl , Michael Zimmermann , Hubert Goll , Paul Wurzinger
Inventor： Reinhard Lihl , Michael Zimmermann , Hubert Goll , Paul Wurzinger
CPC classification number: G01N1/42 , A01N1/0257 , F17C2270/0509 , F25D3/10 , Y10T436/2525
Abstract: A Dewar vessel (1) for automated cryosubstitution or low-temperature substitution is disclosed. The invention further discloses an apparatus (10) for automated liquid transfer for cryosubstitution or low-temperature substitution. The apparatus (10) encompasses a container (50) that encompasses at least one specimen holder (2) and at least one reservoir holder (20); and wherein a movable transfer container (35) for automated exchange of at least one liquid (42) between the at least one specimen holder (2) and the at least one reservoir holder (20) is provided.
Abstract translation: 公开了用于自动冷冻置换或低温置换的杜瓦瓶（1）。 本发明还公开了一种用于冷冻置换或低温替代的自动化液体转移的装置（10）。 装置（10）包括容纳至少一个样本保持器（2）和至少一个储存器保持器（20）的容器（50）; 并且其中提供用于自动更换所述至少一个样本保持器（2）和所述至少一个储存器保持器（20）之间的至少一个液体（42）的可移动转移容器（35）。
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公开(公告)号：US20050078471A1
公开(公告)日：2005-04-14
申请号：US10711406
申请日：2004-09-16
Applicant: Reinhard Lihl , Siegfried Tanki , Michael Zimmermann
Inventor： Reinhard Lihl , Siegfried Tanki , Michael Zimmermann
CPC classification number: G02B21/28 , G01N1/06 , G01N1/42 , G01N2001/068 , Y10S362/80 , Y10T83/283 , Y10T83/828
Abstract: A cooling chamber 10 for a microtome 1 is disclosed. A knife 2 having a cutting edge 16 is arranged in the cooling chamber 10 opposite a sample holder 4 having a sample 4a retained therein. The microtome 1 further possesses a stereomicroscope 12 having an optical system 14, the optical system 14 defining an optical axis 11. The region of the sample 4a and of the cutting edge 16 of the knife 2 is observable with the stereomicroscope 12. There is mounted in the cooling chamber 10 an illumination system 20 that emits light 20a and is directed onto a surface 2a of the knife 2 in such a way that the light 20a reflects from the surface 2a parallel to the optical axis 11.
Abstract translation: 公开了一种用于切片机1的冷却室10。 具有切削刃16的刀具2布置在冷却室10中，与具有保留在其中的样品4a的样品保持器4相对。 切片机1还具有立体显微镜12，其具有光学系统14，光学系统14限定光轴11.样品4a的区域和刀2的切割边缘16的区域可用立体显微镜12观察到。安装 在冷却室10中，照射系统20发射光20a并被引导到刀2的表面2a上，使得光20a从平行于光轴11的表面2a反射。
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公开(公告)号：US20070033681A1
公开(公告)日：2007-02-08
申请号：US11462378
申请日：2006-08-04
Applicant: Reinhard Lihl , Michael Zimmermann
Inventor： Reinhard Lihl , Michael Zimmermann
IPC: A61B17/32
CPC classification number: G01N1/06 , B01L1/00 , B01L2300/1894 , G01N1/42 , Y10T83/222
Abstract: A device (1) for sectioning specimens comprises a microtome or an ultramicrotome (3) for generating thin specimen pieces. A table (5) for placement of the microtome or ultramicrotome (3) is provided, a cold chamber (30) being provided that surrounds a region of the microtome or ultramicrotome (3) for generating thin specimen pieces. A glovebox (42) surrounds the microtome or ultramicrotome (3) and the cold chamber (30). The glovebox (30) stands on the table (5), and a coolant hose (37) connects a reservoir vessel (35) with coolant to the cold chamber (30). The coolant evaporating out of the cold chamber (30) fills the glovebox (42).
Abstract translation: 用于切片试样的装置（1）包括用于产生薄样品的切片机或超薄切片机（3）。 提供了用于放置切片机或超薄切片机（3）的台（5），设置有围绕切片机或超薄切片机（3）的区域的冷室（30），用于产生薄的样品片。 手套箱（42）围绕切片机或超薄切片机（3）和冷室（30）。 手套箱（30）站立在工作台（5）上，并且冷却剂软管（37）将储存容器（35）与冷却剂连接到冷室（30）。 从冷室（30）中蒸发的冷却剂填充手套箱（42）。
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公开(公告)号：US07104666B2
公开(公告)日：2006-09-12
申请号：US10711406
申请日：2004-09-16
Applicant: Reinhard Lihl , Siegfried Tanki , Michael Zimmermann
Inventor： Reinhard Lihl , Siegfried Tanki , Michael Zimmermann
IPC: F21V33/00
CPC classification number: G02B21/28 , G01N1/06 , G01N1/42 , G01N2001/068 , Y10S362/80 , Y10T83/283 , Y10T83/828
Abstract: A cooling chamber 10 for a microtome 1 is disclosed. A knife 2 having a cutting edge 16 is arranged in the cooling chamber 10 opposite a sample holder 4 having a sample 4a retained therein. The microtome 1 further possesses a stereomicroscope 12 having an optical system 14, the optical system 14 defining an optical axis 11. The region of the sample 4a and of the cutting edge 16 of the knife 2 is observable with the stereomicroscope 12. There is mounted in the cooling chamber 10 an illumination system 20 that emits light 20a and is directed onto a surface 2a of the knife 2 in such a way that the light 20a reflects from the surface 2a parallel to the optical axis 11.
Abstract translation: 公开了一种用于切片机1的冷却室10。 具有切削刃16的刀具2布置在冷却室10中，与具有保持在其中的样品4a的样品架4相对。 切片机1还具有具有光学系统14的立体显微镜12，光学系统14限定光轴11。 用立体显微镜12观察刀2的样品4a和切割刃16的区域。 在冷却室10中安装有照射系统20，该照明系统20发光20a，并且以这样的方式被引导到刀2的表面2a上，使得光20a从表面2a平行于光轴11反射 。
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