公开(公告)号：US12011463B2

公开(公告)日：2024-06-18

申请号：US16933492

申请日：2020-07-20

申请人： Reapplix ApS

发明人： Rasmus Lundquist ,  Niels Erik Holm

IPC分类号： A61K35/19 ,  A61K35/15 ,  A61K35/33 ,  A61K38/15 ,  A61K38/17 ,  A61K38/36 ,  A61L24/10 ,  B04B5/04 ,  C12N5/078 ,  C12N5/0787 ,  G01N33/49 ,  A61L26/00 ,  A61M1/02

CPC分类号： A61K35/19 ,  A61K35/15 ,  A61K35/33 ,  A61K38/15 ,  A61K38/17 ,  A61K38/36 ,  A61K38/363 ,  A61L24/106 ,  B04B5/04 ,  C12N5/0642 ,  C12N5/0644 ,  G01N33/49 ,  A61L26/0042 ,  A61M1/029 ,  B04B2005/0485 ,  C12N2501/905 ,  G01N33/491 ,  A61K38/363 ,  A61K2300/00 ,  A61K38/15 ,  A61K2300/00 ,  A61K38/17 ,  A61K2300/00 ,  A61K35/19 ,  A61K2300/00 ,  A61K35/15 ,  A61K2300/00

摘要： A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.

公开(公告)号：US11420138B2

公开(公告)日：2022-08-23

申请号：US16106595

申请日：2018-08-21

申请人： REAPPLIX APS

发明人： Rasmus Lundquist ,  Niels Erik Holm

IPC分类号： B01L3/00 ,  B01D21/26 ,  A61M1/02 ,  A61M1/36

摘要： A container to be used for preparing a multi-layered blood product by centrifugation comprises a substantially cylindrical body (2) with a closed bottom (3) and a top (4) having a filling opening as well as a filter device (15), which is slidable inside the container (1). The filing opening is closed by means of a penetrable membrane (13), and the filter device (15) comprises a substantially planar mesh (16) and a supporting buoyancy body (18). In addition to this, there are means (35, 36, 39, 40, 42), for releasable fixation of the filter device (15) adjacent to the bottom (3) of the container (1).

公开(公告)号：US10716812B2

公开(公告)日：2020-07-21

申请号：US14599641

申请日：2015-01-19

申请人： Reapplix ApS

发明人： Rasmus Lundquist ,  Niels Erik Holm

IPC分类号： A61K35/19 ,  A61K38/15 ,  A61K38/17 ,  A61K38/36 ,  B04B5/04 ,  A61K35/15 ,  A61L24/10 ,  A61K35/33 ,  C12N5/0787 ,  C12N5/078 ,  A61L26/00

摘要： A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.

公开(公告)号：US12029561B2

公开(公告)日：2024-07-09

申请号：US16068514

申请日：2017-01-06

申请人： REAPPLIX APS

发明人： Rasmus Lundquist ,  Niels Erik Holm

IPC分类号： A61B5/15 ,  A61B5/154 ,  B01L3/00 ,  G01N33/49

CPC分类号： A61B5/150755 ,  A61B5/15003 ,  A61B5/150099 ,  A61B5/150274 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473 ,  A61B5/154 ,  B01L3/5082 ,  G01N33/491 ,  A61B5/1438 ,  A61B5/150503 ,  B01L3/505

摘要： Provided is a blood collection unit suitable for accelerated blood coagulation of whole blood for subsequent autologous or allogeneic use. The blood collection unit includes an inside surface that an activation site accelerating coagulation by having a high roughness. Further provided is a blood collection unit including an inside surface that has an activation site having a high roughness area, and an interior of the blood collection unit has been prepared with a pressure of no more than 255 mBar, and preferably a pressure of no more than 130 mBar.

公开(公告)号：US10933095B2

公开(公告)日：2021-03-02

申请号：US14599641

申请日：2015-01-19

申请人： Reapplix ApS

发明人： Rasmus Lundquist ,  Niels Erik Holm

IPC分类号： A61K35/19 ,  A61K38/36 ,  A61K38/17 ,  A61K38/15 ,  A61K35/33 ,  A61K35/15 ,  A61L24/10 ,  B04B5/04 ,  C12N5/0787 ,  C12N5/078 ,  A61L26/00

摘要： A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.