公开(公告)号：US20150335390A1

公开(公告)日：2015-11-26

申请号：US14820310

申请日：2015-08-06

Applicant: RENISHAW (IRELAND) LIMITED

Inventor： Steven Streatfield GILL

IPC: A61B19/00 ,  A61B6/00 ,  A61G13/00 ,  G06T7/00 ,  A61B6/03

CPC classification number: A61B90/37 ,  A61B6/032 ,  A61B6/501 ,  A61B34/20 ,  A61B34/30 ,  A61B90/39 ,  A61B2017/00694 ,  A61B2034/107 ,  A61B2034/2065 ,  A61B2034/303 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/3966 ,  A61B2090/3983 ,  A61G13/00 ,  G06T7/0014 ,  G06T7/337 ,  G06T7/74 ,  G06T2200/04 ,  G06T2207/10081 ,  G06T2207/30016 ,  G06T2207/30101 ,  G06T2210/41

Abstract: A method is described for determining brain shift, such as the brain shift that occurs following a neurosurgical intervention. The method comprises taking a first image of the brain (4) of a subject, the first image showing the position of blood vessels (20) in the brain relative to a reference position (30). A second image of the brain (4), that has been acquired following an intervention on the subject is also taken. This second image has been acquired using computed tomography (CT) imaging apparatus, The second image shows the position of blood vessels (20′) in the brain relative to the reference position (30). Brain shift is then determined from the shift in position of the blood vessels in at least one region of interest (32) of the brain, with respect to the reference position (30), between the first and second images. Corresponding apparatus is also described.

Abstract translation: 描述了一种用于确定脑移位的方法，例如在神经外科手术后发生的脑移位。 该方法包括拍摄对象的大脑（4）的第一图像，第一图像显示相对于参考位置（30）在脑中的血管位置（20）。 大脑（4）的第二张图像也是采取干预措施后获得的。 该第二图像已经使用计算机断层摄影（CT）成像装置获得。第二图像显示了脑中相对于参考位置（30）的血管（20'）的位置。 然后，在第一和第二图像之间相对于参考位置（30）从大脑的至少一个感兴趣区域（32）中的血管的位置位移确定脑移位。 还描述了相应的装置。

公开(公告)号：US20200376252A1

公开(公告)日：2020-12-03

申请号：US16998491

申请日：2020-08-20

Applicant: RENISHAW (IRELAND) LIMITED

Inventor： Steven Streatfield GILL ,  Paul David FIELDER

IPC: A61M39/02

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

公开(公告)号：US20140236128A1

公开(公告)日：2014-08-21

申请号：US14262159

申请日：2014-04-25

Applicant: RENISHAW (IRELAND) LIMITED

Inventor： Steven Streatfield GILL

IPC: A61M39/02 ,  A61M39/10 ,  A61M5/14

CPC classification number: A61M39/0208 ,  A61M5/14 ,  A61M5/1408 ,  A61M5/142 ,  A61M5/14244 ,  A61M39/0247 ,  A61M39/10 ,  A61M2039/0205 ,  A61M2039/0229 ,  A61M2039/0232 ,  A61M2039/025 ,  A61M2039/1066 ,  A61M2205/04 ,  A61M2210/0693

Abstract: A method for delivering fluid to a brain of a subject using a modular fluid delivery apparatus is described. The method comprises taking a subject having a first part of the modular fluid delivery apparatus subcutaneously implanted therein, the first part of the modular fluid delivery apparatus comprising a first end having a first fluid connector portion attached thereto and a second end being connected to one or more catheters implanted within the brain of the subject. The method also comprises taking a second part of the modular fluid delivery apparatus, the second part comprising a third end comprising a second fluid connector portion. The method further comprises making an incision in the subject to gain access to the first fluid connector portion of the first part of the modular fluid delivery apparatus, and connecting the first fluid connector portion to the second fluid connector portion.

Abstract translation: 描述了使用模块化流体输送装置将流体输送到对象的脑部的方法。 该方法包括将具有其中的模块化流体输送装置的第一部分的受试者皮下植入其中，模块化流体输送装置的第一部分包括具有连接到其上的第一流体连接器部分的第一端部， 更多的导管植入受试者的脑部。 该方法还包括取出模块化流体输送装置的第二部分，第二部分包括包括第二流体连接器部分的第三端。 该方法还包括在受试者中进行切口以进入模块化流体输送装置的第一部分的第一流体连接器部分，并将第一流体连接器部分连接到第二流体连接器部分。

公开(公告)号：US20180369555A1

公开(公告)日：2018-12-27

申请号：US16046525

申请日：2018-07-26

Applicant: RENISHAW (IRELAND) LIMITED

Inventor： Maxwell Roy WOOLLEY ,  David Roberts MCMURTRY ,  Steven Streatfield GILL

IPC: A61M39/02

Abstract: Percutaneous access apparatus is described that comprises a percutaneous fluid access device having an extracorporeal portion, one or more ports accessible from the extracorporeal portion and a septum for sealing each port. A connector device comprising one or more hollow needles is attachable to the percutaneous fluid access device. The apparatus also includes an attachment mechanism for attaching the connector device to the extracorporeal portion and an actuation mechanism that, after the connector device has been attached to the extracorporeal portion, can be used to drive the one or more hollow needles through the septum to establish fluid communication between the one or more hollow needles and the one or more ports. The apparatus may be used for neurosurgery applications.

公开(公告)号：US20150352347A1

公开(公告)日：2015-12-10

申请号：US14827720

申请日：2015-08-17

Applicant: RENISHAW (IRELAND) LIMITED

Inventor： Steven Streatfield GILL

IPC: A61M39/02 ,  A61M5/142

Abstract: A method for delivering fluid to a brain of a subject is disclosed. This method includes the steps of: making one or more incisions in a subject; implanting one or more catheters in the brain of the subject; subcutaneously implanting a first part of a modular fluid delivery apparatus in the subject, the first part of the modular fluid delivery apparatus comprising a first length of tubing having a first end and a second end, the first end having a first fluid connector portion attached thereto and the second end being connected to the one or more catheters; and closing the one or more incisions such that the first part of the modular fluid delivery apparatus and the one or more catheters are entirely subcutaneously implanted within the subject.

Abstract translation: 公开了一种将流体输送到受试者的脑部的方法。 该方法包括以下步骤：在受试者中进行一个或多个切口; 将一个或多个导管植入受试者的脑中; 将模块化流体输送装置的第一部分皮下植入到受试者中，模块化流体输送装置的第一部分包括具有第一端和第二端的第一长度的管，第一端具有连接到其上的第一流体连接部 并且所述第二端连接到所述一个或多个导管; 并且关闭所述一个或多个切口，使得所述模块化流体输送装置的第一部分和所述一个或多个导管完全皮下植入所述受试者内。

公开(公告)号：US20150157842A1

公开(公告)日：2015-06-11

申请号：US14581549

申请日：2014-12-23

Applicant: RENISHAW (IRELAND) LIMITED

Inventor： Steven Streatfield GILL ,  Paul David FIELDER

IPC: A61M39/02

CPC classification number: A61M39/0247 ,  A61M2039/025 ,  A61M2039/0264 ,  A61M2039/0276 ,  A61M2039/0282 ,  A61M2039/0285 ,  A61M2039/0291 ,  A61M2210/0693

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

Abstract translation: 描述了将治疗剂递送到受试者的中枢神经系统的装置。 该装置包括至少一个颅内导管和经皮进入装置。 经皮进入装置包括具有至少一个体外表面和至少一个皮下表面的主体，该主体限定用于连接到植入的颅内导管的至少一个端口。 该端口可从装置的体外表面接近，但是在端口的内腔和体外表面之间设置有诸如橡胶塞之类的密封件。 经皮进入装置可具有多于两个的端口和/或凸缘。 还描述了植入经皮进入装置的方法。