公开(公告)号：US11921096B2

公开(公告)日：2024-03-05

申请号：US17012642

申请日：2020-09-04

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson ,  Raia Colette Finc ,  Michael J. Lyden ,  John M. Darst ,  Michael Mathias Freking

IPC: G01N33/00 ,  G01N27/447 ,  G01N27/70

CPC classification number: G01N33/0008 ,  G01N27/44765 ,  G01N27/70 ,  G01N33/0034

Abstract: Embodiments herein relate to breath analysis system. In an embodiment, a gas measurement device is included having a housing defining an interior volume. The housing can include a fluid ingress port, a fluid egress port, a bottom wall, and a circuit board disposed within the interior volume. The circuit board can include a first side and a second side, where the first side of the circuit board faces inward toward the interior volume. The circuit board can include a plurality of gas sensors disposed on the first side of the circuit board and a plurality of conductive pads disposed on the second side of the circuit board, wherein a plurality of electrical contacts contact the conductive pads when the circuit board is seated within the housing. Other embodiments are also included herein.

公开(公告)号：US20230184741A1

公开(公告)日：2023-06-15

申请号：US17941364

申请日：2022-09-09

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Gregory Kermit Peterson ,  Justin Theodore Nelson ,  Gregory J. Sherwood

IPC: G01N33/497 ,  G01N1/22 ,  G01N27/22

CPC classification number: G01N33/497 ,  G01N1/2226 ,  G01N27/227 ,  G01N33/4972 ,  G01N2001/2244

Abstract: Embodiments herein include a method for detecting a brain condition in a subject. The method can include obtaining a breath sample from the subject and contacting it with a chemical sensor element, where the chemical sensor element includes a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set and classifying the sample data set into one or more preestablished brain condition classifications. Other embodiments are also included herein.

公开(公告)号：US20220125325A1

公开(公告)日：2022-04-28

申请号：US17520339

申请日：2021-11-05

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Arthur Guy Erdman ,  Gregory J. Sherwood ,  Gregory Kermit Peterson ,  Justin Theodore Nelson ,  Michael Mathias Freking

IPC: A61B5/0205 ,  A61B5/00

Abstract: Embodiments herein include a breath sampling mask, systems, and related methods. In an embodiment, a breath sensing system is included. The breath sensing system can include a breath sampling mask. The breath sampling mask can include a mask housing configured to cover a portion of the face of a patient. The mask housing can define a breath receiving chamber. The breath sampling mask can include a chemical sensor element in fluid communication with the breath sampling mask, where the chemical sensor element can include a plurality of discrete binding detectors. The chemical sensor element can interface with a breath sample collected through the breath sampling mask. Other embodiments are also included herein.

公开(公告)号：US20240319152A1

公开(公告)日：2024-09-26

申请号：US18585358

申请日：2024-02-23

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson ,  Raia Colette Finc ,  Michael J. Lyden ,  John M. Darst ,  Michael Mathias Freking

IPC: G01N33/00 ,  G01N27/447 ,  G01N27/70

CPC classification number: G01N33/0008 ,  G01N27/44765 ,  G01N27/70 ,  G01N33/0034

Abstract: Embodiments herein relate to breath analysis system. In an embodiment, a gas measurement device is included having a housing defining an interior volume. The housing can include a fluid ingress port, a fluid egress port, a bottom wall, and a circuit board disposed within the interior volume. The circuit board can include a first side and a second side, where the first side of the circuit board faces inward toward the interior volume. The circuit board can include a plurality of gas sensors disposed on the first side of the circuit board and a plurality of conductive pads disposed on the second side of the circuit board, wherein a plurality of electrical contacts contact the conductive pads when the circuit board is seated within the housing. Other embodiments are also included herein.

公开(公告)号：US20230393087A1

公开(公告)日：2023-12-07

申请号：US18144506

申请日：2023-05-08

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson ,  Steven Koester

IPC: G01N27/02 ,  G01N27/22

CPC classification number: G01N27/021 ,  G01N27/221 ,  G01N27/227 ,  G01N33/0036

Abstract: Embodiments herein include a kinetic response system for measuring analyte presence on a chemical sensor element. The chemical sensor element includes one or more discrete binding detectors, each discrete binding detector including a graphene varactor. The kinetic response system includes a measurement circuit having an excitation voltage generator for generating a series of excitation cycles over a time period. Each excitation cycle includes delivering a DC bias voltage to the discrete binding detectors at multiple discrete DC bias voltages across a range of DC bias voltages. The kinetic response system includes a capacitance sensor to measure capacitance of the discrete binding detectors resulting from the excitation cycles. The kinetic response system includes a controller circuit to determine the kinetics of change in at least one of a measured capacitance value and a calculated value based on the measured capacitance over the time period. Other embodiments are also included herein.

公开(公告)号：US20190254538A1

公开(公告)日：2019-08-22

申请号：US16280644

申请日：2019-02-20

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Arthur Guy Erdman ,  Gregory J. Sherwood ,  Gregory Kermit Peterson ,  Justin Theodore Nelson ,  Michael Mathias Freking

IPC: A61B5/0205 ,  A61B5/00

Abstract: Embodiments herein include a breath sampling mask, systems, and related methods. In an embodiment, a breath sensing system is included. The breath sensing system can include a breath sampling mask. The breath sampling mask can include a mask housing configured to cover a portion of the face of a patient. The mask housing can define a breath receiving chamber. The breath sampling mask can include a chemical sensor element in fluid communication with the breath sampling mask, where the chemical sensor element can include a plurality of discrete binding detectors. The chemical sensor element can interface with a breath sample collected through the breath sampling mask. Other embodiments are also included herein.

公开(公告)号：US20240255391A1

公开(公告)日：2024-08-01

申请号：US18528088

申请日：2023-12-04

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson

IPC: G01N1/22 ,  G01N27/22 ,  G16H15/00 ,  G16H20/00 ,  G16H50/20 ,  G16H50/30

CPC classification number: G01N1/2226 ,  G01N27/22 ,  G16H15/00 ,  G16H20/00 ,  G16H50/20 ,  G16H50/30 ,  G01N2001/2229 ,  G01N2027/222

Abstract: Embodiments herein include a method for detecting a health condition of a subject. The method can include obtaining a biological sample from the subject and placing it into a container having a headspace surrounding the biological sample. The method can include contacting a gas from the headspace with a chemical sensor element, the chemical sensor element including one or more discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set. Other embodiments are also included herein.

公开(公告)号：US12007385B2

公开(公告)日：2024-06-11

申请号：US17941364

申请日：2022-09-09

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory Kermit Peterson ,  Justin Theodore Nelson ,  Gregory J. Sherwood

IPC: G01N33/497 ,  G01N1/22 ,  G01N27/22

CPC classification number: G01N33/497 ,  G01N1/2226 ,  G01N27/227 ,  G01N2001/2244 ,  G01N33/4972

Abstract: Embodiments herein include a method for detecting a brain condition in a subject. The method can include obtaining a breath sample from the subject and contacting it with a chemical sensor element, where the chemical sensor element includes a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set and classifying the sample data set into one or more preestablished brain condition classifications. Other embodiments are also included herein.

公开(公告)号：US11835435B2

公开(公告)日：2023-12-05

申请号：US16696348

申请日：2019-11-26

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson

IPC: G16H50/20 ,  G16H50/30 ,  G01N27/22 ,  G01N1/22 ,  G16H15/00 ,  G16H20/00

CPC classification number: G01N1/2226 ,  G01N27/22 ,  G16H15/00 ,  G16H20/00 ,  G16H50/20 ,  G16H50/30 ,  G01N2001/2229 ,  G01N2027/222

Abstract: Embodiments herein include a method for detecting a health condition of a subject. The method can include obtaining a biological sample from the subject and placing it into a container having a headspace surrounding the biological sample. The method can include contacting a gas from the headspace with a chemical sensor element, the chemical sensor element including one or more discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set. Other embodiments are also included herein.

公开(公告)号：US11662325B2

公开(公告)日：2023-05-30

申请号：US16712255

申请日：2019-12-12

Applicant: Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Gregory J. Sherwood ,  Justin Theodore Nelson ,  Steven J. Koester

IPC: G01N27/02 ,  G01N27/22 ,  G01N33/00

CPC classification number: G01N27/021 ,  G01N27/221 ,  G01N27/227 ,  G01N33/0036

Abstract: Embodiments herein include a kinetic response system for measuring analyte presence on a chemical sensor element. The chemical sensor element includes one or more discrete binding detectors, each discrete binding detector including a graphene varactor. The kinetic response system includes a measurement circuit having an excitation voltage generator for generating a series of excitation cycles over a time period. Each excitation cycle includes delivering a DC bias voltage to the discrete binding detectors at multiple discrete DC bias voltages across a range of DC bias voltages. The kinetic response system includes a capacitance sensor to measure capacitance of the discrete binding detectors resulting from the excitation cycles. The kinetic response system includes a controller circuit to determine the kinetics of change in at least one of a measured capacitance value and a calculated value based on the measured capacitance over the time period. Other embodiments are also included herein.