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1.发明申请公开(公告)号：US20220265748A1
公开(公告)日：2022-08-25
申请号：US17584661
申请日：2022-01-26
发明人： Christopher W. Shade , Steven Tieu
IPC分类号： A61K36/288 , A61K9/107 , A61K36/328 , A61K47/44 , A61K31/355 , A61K36/515 , A61K9/00 , A61K31/381 , A61K31/404 , A61K47/14
摘要： An intra-oral, nanoemulsion blend is provided that enhances liver and toxin excretion performance in mammals when orally administered. A solid powder toxin binding composition also is provided that may be used to irreversibly bind the toxins reaching the bowel so that once the toxins are excreted into the bowel, they may not be reabsorbed, and are thus eliminated. A method of administering the nanoemulsion blend and the toxin binding composition to enhance toxin excretion also is described. The nanoemulsion blend is ingestible and edible.
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2.发明公开公开(公告)号：US20240335381A1
公开(公告)日：2024-10-10
申请号：US18629522
申请日：2024-04-08
发明人： Christopher W. Shade , Steven Tieu , James R Huey
IPC分类号： A61K9/107 , A61K9/00 , A61K31/57 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/44 , A61P5/24
CPC分类号： A61K9/1075 , A61K9/0014 , A61K31/57 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/44 , A61P5/24
摘要： Thickened microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. In relation to conventional oil-in-water (OIW) microemulsions, the described thickened microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the thickened MOIW microemulsion are modified with alcohol and an alcohol-lipid phase thickener and can solubilize alcohol-soluble species, including nonderivatized hormones. Preferably, the modified oil phase droplets of the thickened MOIW microemulsion directly solubilize nonderivatized hormones. The polar continuous “water” phase of the thickened MOIW microemulsion is modified with a continuous phase thickener. The modified oil phase droplets disperse into the modified polar continuous phase of the thickened MOIW microemulsion.
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3.发明公开公开(公告)号：US20230398164A1
公开(公告)日：2023-12-14
申请号：US18209168
申请日：2023-06-13
发明人： Christopher W. Shade , Steven Tieu
IPC分类号： A61K36/288 , A61K47/44 , A61K31/404 , A61K31/381 , A61K47/14 , A61K9/107 , A61K36/515 , A61K36/328 , A61K31/355 , A61K9/00 , B82Y5/00
CPC分类号： A61K36/288 , A61K47/44 , A61K31/404 , A61K31/381 , A61K47/14 , A61K9/1075 , A61K36/515 , A61K36/328 , A61K31/355 , A61K9/0053 , B82Y5/00
摘要： An intra-oral, nanoemulsion assists in balancing the histamine response in subjects when orally administered. The intra-oral, nanoemulsion includes at least one monolayer surfactant bound particle and a continuous phase. The monolayer surfactant bound particles are carried by the continuous phase. A method of making and of administering the nanoemulsion to balance the histamine response in subjects also is described. The nanoemulsion is ingestible and edible.
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公开(公告)号：US20230114405A1
公开(公告)日：2023-04-13
申请号：US17967267
申请日：2022-10-17
发明人： Christopher W. Shade , Steven Tieu
摘要： Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol.
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公开(公告)号：US20220233441A1
公开(公告)日：2022-07-28
申请号：US17672988
申请日：2022-02-16
发明人： Christopher W. Shade , Steven Tieu
摘要： Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize oil-soluble species, including cannabis extracts and terpenes. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol.
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公开(公告)号：US12121558B2
公开(公告)日：2024-10-22
申请号：US17584661
申请日：2022-01-26
发明人： Christopher W. Shade , Steven Tieu
IPC分类号： A61K36/288 , A61K9/00 , A61K9/107 , A61K31/355 , A61K31/381 , A61K31/404 , A61K36/328 , A61K36/515 , A61K47/14 , A61K47/44 , B82Y5/00
CPC分类号： A61K36/288 , A61K9/0053 , A61K9/1075 , A61K31/355 , A61K31/381 , A61K31/404 , A61K36/328 , A61K36/515 , A61K47/14 , A61K47/44 , B82Y5/00
摘要： An intra-oral, nanoemulsion blend is provided that enhances liver and toxin excretion performance in mammals when orally administered. A solid powder toxin binding composition also is provided that may be used to irreversibly bind the toxins reaching the bowel so that once the toxins are excreted into the bowel, they may not be reabsorbed, and are thus eliminated. A method of administering the nanoemulsion blend and the toxin binding composition to enhance toxin excretion also is described. The nanoemulsion blend is ingestible and edible.
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7.发明申请公开(公告)号：US20220241201A1
公开(公告)日：2022-08-04
申请号：US17672894
申请日：2022-02-16
发明人： Christopher W. Shade , Steven Tieu
摘要： Microemulsions are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsions may be thought of as modified oil-in-water (MOIW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIW microemulsion are modified with alcohol and can solubilize alcohol-soluble species, including nonderivatized hormones. The polar continuous “water” phase of the MOIW microemulsion is modified with a sugar or sugar alcohol.
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公开(公告)号：US20220304927A1
公开(公告)日：2022-09-29
申请号：US17730571
申请日：2022-04-27
发明人： Christopher W. Shade , Steven Tieu
摘要： An aqueous, intra-oral, nanoemulsion blend is provided that enhances mitochondrial performance in mammals when orally administered. The blend includes at least two different monolayer surfactant bound particle components and at least one bilayer water-core liposome component. The blend optionally may include a micelle.
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公开(公告)号：US20220241192A1
公开(公告)日：2022-08-04
申请号：US17673086
申请日：2022-02-16
发明人： Christopher W. Shade , Steven Tieu
IPC分类号： A61K9/00 , A61K9/107 , A61K31/05 , A61K31/352 , A61K31/015 , A61K31/045 , A61K31/07 , A61K31/01 , A61K47/44 , A61K47/14 , A61K47/26 , A61K47/10 , A61K47/24
摘要： Microemulsion beverages are described where hydrophobic liquid droplets are distributed in a continuous hydrophilic liquid phase. The described microemulsion beverages may be thought of as modified oil-in-water (MOIHW) microemulsions, where both the “oil” and “water” phases of the microemulsion are modified. The oil phase droplets of the MOIHW microemulsion are modified with alcohol and can solubilize oil-soluble species, including cannabis extracts. The polar continuous “water” phase of the MOIHW microemulsion is modified with a sugar or sugar alcohol.
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10.发明授权公开(公告)号：US11291702B1
公开(公告)日：2022-04-05
申请号：US16849654
申请日：2020-04-15
发明人： Christopher W. Shade , Steven Tieu
IPC分类号： A61K36/288 , A61K31/381 , A61K31/404 , A61K31/355 , A61K36/328 , A61K47/14 , A61K47/44 , A61K9/00 , A61K9/107 , A61K36/515 , B82Y5/00
摘要： An intra-oral, nanoemulsion blend is provided that enhances liver and toxin excretion performance in mammals when orally administered. A solid powder toxin binding composition also is provided that may be used to irreversibly bind the toxins reaching the bowel so that once the toxins are excreted into the bowel, they may not be reabsorbed, and are thus eliminated. A method of administering the nanoemulsion blend and the toxin binding composition to enhance toxin excretion also is described. The nanoemulsion blend is ingestible and edible.
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