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公开(公告)号：US06809180B2
公开(公告)日：2004-10-26
申请号：US09832464
申请日：2001-04-11
Applicant: Piet A. J. de Boer , Cynthia A. Hale
Inventor： Piet A. J. de Boer , Cynthia A. Hale
IPC: C07K14245
CPC classification number: C07K14/245 , G01N33/9446 , Y10S530/81 , Y10S530/811 , Y10S530/814 , Y10S530/817 , Y10S530/825 , Y10S930/28
Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein—protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
Abstract translation: 描述了筛选化合物用于抗微生物活性的方法，其在体外利用细菌蛋白质 - 蛋白质结合。 该方法可以使用固定化元件进行，并且可以使用各种固定装置（例如，柱，珠，吸附剂，硝化纤维素纸等）进行固定以筛选大量化合物文库。
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公开(公告)号：US5948889A
公开(公告)日：1999-09-07
申请号：US651818
申请日：1996-05-21
Applicant: Piet A. J. de Boer , Cynthia A. Hale
Inventor： Piet A. J. de Boer , Cynthia A. Hale
IPC: C12N15/09 , C07K5/097 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/245 , C07K19/00 , C12N15/00 , C12N15/31 , C12Q1/25 , C12R1/19 , G01N33/15 , G01N33/53 , G01N33/94 , C07K14/195 , C07K17/02 , C07K17/14
CPC classification number: C07K14/245 , G01N33/9446 , Y10S530/81 , Y10S530/811 , Y10S530/814 , Y10S530/817 , Y10S530/825 , Y10S930/28
Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
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公开(公告)号：US07326566B2
公开(公告)日：2008-02-05
申请号：US10901897
申请日：2004-07-29
Applicant: Piet A. J. de Boer , Cynthia A. Hale
Inventor： Piet A. J. de Boer , Cynthia A. Hale
CPC classification number: C07K14/245 , G01N33/9446 , Y10S530/81 , Y10S530/811 , Y10S530/814 , Y10S530/817 , Y10S530/825 , Y10S930/28
Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
Abstract translation: 描述了筛选化合物用于抗微生物活性的方法，其在体外利用细菌蛋白质 - 蛋白质结合。 该方法可以使用固定化元件进行，并且可以使用各种固定装置（例如，柱，珠，吸附剂，硝化纤维素纸等）进行固定以筛选大量化合物文库。
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公开(公告)号：US06248543B1
公开(公告)日：2001-06-19
申请号：US09184826
申请日：1998-11-02
Applicant: Piet A. J. de Boer , Cynthia A. Hale
Inventor： Piet A. J. de Boer , Cynthia A. Hale
IPC: G01N33569
CPC classification number: C07K14/245 , G01N33/9446 , Y10S530/81 , Y10S530/811 , Y10S530/814 , Y10S530/817 , Y10S530/825 , Y10S930/28
Abstract: A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
Abstract translation: 描述了筛选化合物用于抗微生物活性的方法，其在体外利用细菌蛋白质 - 蛋白质结合。 该方法可以使用固定化元件进行，并且可以使用各种固定装置（例如，柱，珠，吸附剂，硝化纤维素纸等）进行固定以筛选大量化合物文库。
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