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公开(公告)号：US08965497B2
公开(公告)日：2015-02-24
申请号：US11922812
申请日：2006-06-22
CPC分类号： A61B5/053 , A61B5/0002 , A61B5/05 , A61B5/14539 , A61B5/14546 , A61B5/6825 , A61B5/6829 , A61B5/742
摘要： The invention relates to an electrophysiological analysis system which comprises a plurality of electrodes (E1-E4), power supply means (10, 30) for successively applying a substantially continuous voltage ranging approximately from 1 to 5 volts and lasting from 0.1 to 5 seconds to different slotted electrode pairs, collecting and storing means (450) for recording the variation of a current flow in the electrode pairs to which said voltage slots are applied, means (50) for enabling the current variations obtained by comparison between at least two current variations caused by supposed identical conditions and means (50) for comparing data related to the current variations recorded for several electrode pairs and enabled with reference data. Said invention can be used for chronoamperometrically detecting pathologies, pathological areas and organ dysfunctions.
摘要翻译： 本发明涉及一种电生理分析系统，其包括多个电极（E1-E4），电源装置（10,30），用于连续施加约1至5伏范围内持续0.1至5秒的基本上连续的电压并持续0.1至5秒， 不同的开槽电极对，用于记录施加所述电压槽的电极对中的电流变化的收集和存储装置（450），用于使通过比较至少两个电流变化获得的电流变化的装置（50） 由假定的相同条件和装置（50）引起，用于比较与针对若干电极对记录的当前变化相关的数据并且使能参考数据。 所述发明可用于计时电位检测病变，病理区域和器官功能障碍。
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公开(公告)号：US20100274113A1
公开(公告)日：2010-10-28
申请号：US12527415
申请日：2008-02-22
IPC分类号： A61B5/04
CPC分类号： A61B5/1477 , A61B5/05 , A61B5/053 , A61B5/14539 , A61B5/14546 , A61B5/1495 , A61B5/6825 , A61B5/6829 , A61B5/7282 , A61B5/743
摘要： The invention provides an electrophysiological analysis system, in particular for detecting pathological states. This system comprises: electrodes intended to be placed in different regions of the body that are well away from each other; an adjustable DC voltage source for generating successive DC voltage pulses varying in magnitude from one pulse to another, the duration of the pulses being equal to or greater than about 0.2 seconds; a switching circuit for selectively connecting a pair of active electrodes to the voltage source and for connecting at least one other high-impedance electrode; and a measurement circuit for recording data representative of the current in the active electrodes and potentials on at least certain high-impedance connected electrodes in response to the application of said pulses. The range of voltages covered causes, from one pulse to another, the appearance or disappearance of electrochemical phenomena in the vicinity of the active electrodes.
摘要翻译： 本发明提供电生理分析系统，特别是用于检测病理状态。 该系统包括：用于放置在远离彼此的身体的不同区域中的电极; 用于产生从一个脉冲到另一个脉冲在幅度上变化的连续DC电压脉冲的可调直流电压源，脉冲的持续时间等于或大于约0.2秒; 切换电路，用于选择性地将一对有源电极连接到电压源并连接至少一个其它高阻抗电极; 以及测量电路，用于响应于所述脉冲的应用，记录表示有源电极中的电流的数据和至少某些高阻抗连接电极上的电位。 电压范围从一个脉冲到另一个脉冲，导致在活性电极附近的电化学现象的出现或消失。
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公开(公告)号：US08655443B2
公开(公告)日：2014-02-18
申请号：US12527415
申请日：2008-02-22
IPC分类号： A61B5/05
CPC分类号： A61B5/1477 , A61B5/05 , A61B5/053 , A61B5/14539 , A61B5/14546 , A61B5/1495 , A61B5/6825 , A61B5/6829 , A61B5/7282 , A61B5/743
摘要： The invention provides an electrophysiological analysis system, in particular for detecting pathological states. This system comprises: electrodes intended to be placed in different regions of the body that are well away from each other; an adjustable DC voltage source for generating successive DC voltage pulses varying in magnitude from one pulse to another, the duration of the pulses being equal to or greater than about 0.2 seconds; a switching circuit for selectively connecting a pair of active electrodes to the voltage source and for connecting at least one other high-impedance electrode; and a measurement circuit for recording data representative of the current in the active electrodes and potentials on at least certain high-impedance connected electrodes in response to the application of said pulses. The range of voltages covered causes, from one pulse to another, the appearance or disappearance of electrochemical phenomena in the vicinity of the active electrodes.
摘要翻译： 本发明提供电生理分析系统，特别是用于检测病理状态。 该系统包括：用于放置在远离彼此的身体的不同区域中的电极; 用于产生从一个脉冲到另一个脉冲在幅度上变化的连续DC电压脉冲的可调直流电压源，脉冲的持续时间等于或大于约0.2秒; 切换电路，用于选择性地将一对有源电极连接到电压源并连接至少一个其它高阻抗电极; 以及测量电路，用于响应于所述脉冲的应用，记录表示有源电极中的电流的数据和至少某些高阻抗连接电极上的电位。 电压范围从一个脉冲到另一个脉冲，导致在活性电极附近的电化学现象的出现或消失。
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公开(公告)号：US08934954B2
公开(公告)日：2015-01-13
申请号：US13215813
申请日：2011-08-23
CPC分类号： A61B5/04001 , A61B5/0051 , A61B5/0531 , A61B5/14521 , A61B5/4076 , G06F19/00
摘要： A method for assessing sudomotor function of a patient for evaluating diabetic and autonomous neuropathy is disclosed. The method is performed in a system comprising electrodes intended to be placed on different regions of the patient body, and an adjustable DC source. The method includes applying on the electrodes DC voltage pulses of varying voltage values in order to stress sweat glands, the voltage pulses lasting given durations allowing the stabilization of electrochemical phenomena in the body, near the electrodes; collecting data representative of the current between the electrodes, and of the potential generated on the electrodes for the different DC voltages; from the data, computing results representative of the electrochemical skin conductance of the patient; reconciling the latter data with reference data obtained in the same conditions on patients identified as suffering or not from sudomotor, and identifying the patient as suffering or not from sudomotor dysfunction.
摘要翻译： 公开了评估患者糖尿病和自主神经病变患者的运动功能的方法。 该方法在包括旨在放置在患者身体的不同区域上的电极和可调节DC源的系统中进行。 该方法包括在电极上施加具有变化电压值的DC电压脉冲，以便压迫汗腺，持续给定持续时间的电压脉冲，允许在电极附近稳定身体中的电化学现象; 收集表示电极之间的电流的数据，以及针对不同DC电压在电极上产生的电位; 从数据，计算结果代表患者的电化学皮肤电导率; 将后一数据与在相同条件下获得的患者鉴定为患有或不来自患者的参考数据进行调节，并将患者识别为患有或不起因于运动功能障碍的患者。
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公开(公告)号：US20130053673A1
公开(公告)日：2013-02-28
申请号：US13215788
申请日：2011-08-23
申请人： Philippe Brunswick
发明人： Philippe Brunswick
CPC分类号： A61B5/0531 , A61B5/04002 , A61B5/4076 , A61B5/415 , A61B5/425 , A61B5/4266 , A61B5/441 , A61B5/4893
摘要： A method for detecting cystic fibrosis is disclosed, which is performed in a system comprising an anode and a cathode placed on different regions of the patient body, and an adjustable DC source, which is controlled in order to feed the anode with a DC current. The method includes applying DC voltage pulses of varying voltage values to the anode for given durations allowing the stabilization of electrochemical phenomena in the body in the vicinity of the electrodes, collecting data representative of the current between the electrodes, and of the potentials of the electrodes, for the different DC voltages, and from the data, computing data representative of the electrochemical skin conductance of the patient, and reconciling the latter data with reference data obtained in the same conditions on patients suffering or not from cystic fibrosis, and identifying the patient as suffering or not from cystic fibrosis.
摘要翻译： 公开了一种用于检测囊性纤维化的方法，其在包括放置在患者体的不同区域上的阳极和阴极的系统中进行，以及可调直流电源，其被控制以便以直流电流馈送阳极。 该方法包括向电极施加具有不同电压值的直流电压脉冲给定持续时间，从而允许在电极附近稳定身体中的电化学现象，收集代表电极之间的电流的数据以及电极的电位 ，对于不同的直流电压，以及数据，表示患者的电化学皮肤电导的计算数据，以及将后面的数据与在相同条件下获得的与患有或不来自囊性纤维化的患者相关的参考数据进行调节，并鉴定患者 作为患有或不患囊性纤维化的患者。
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公开(公告)号：US20090326407A1
公开(公告)日：2009-12-31
申请号：US11922812
申请日：2006-06-22
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0002 , A61B5/05 , A61B5/14539 , A61B5/14546 , A61B5/6825 , A61B5/6829 , A61B5/742
摘要： The invention relates to an electrophysiological analysis system which comprises a plurality of electrodes (E1-E4), power supply means (10, 30) for successively applying a substantially continuous voltage ranging approximately from 1 to 5 volts and lasting from 0.1 to 5 seconds to different slotted electrode pairs, collecting and storing means (450) for recording the variation of a current flow in the electrode pairs to which said voltage slots are applied, means (50) for enabling the current variations obtained by comparison between at least two current variations caused by supposed identical conditions and means (50) for comparing data related to the current variations recorded for several electrode pairs and enabled with reference data. Said invention can be used for chronoamperometrically detecting pathologies, pathological areas and organ dysfunctions
摘要翻译： 本发明涉及一种电生理分析系统，其包括多个电极（E1-E4），电源装置（10,30），用于连续施加约1至5伏范围内持续0.1至5秒的基本上连续的电压并持续0.1至5秒， 不同的开槽电极对，用于记录施加所述电压槽的电极对中的电流变化的收集和存储装置（450），用于使通过比较至少两个电流变化获得的电流变化的装置（50） 由假定的相同条件和装置（50）引起，用于比较与针对若干电极对记录的当前变化相关的数据并且使能参考数据。 所述发明可用于计时电位检测病变，病理区域和器官功能障碍
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7.发明申请ASSESSMENT OF SUDOMOR FUNCTION FOR PERIPHERAL DIABETIC NEUROPATHY EVALUATION 有权外周神经病理学评估SUDOMOR功能评估公开(公告)号：US20130053721A1
公开(公告)日：2013-02-28
申请号：US13215813
申请日：2011-08-23
申请人： Philippe Brunswick
发明人： Philippe Brunswick
IPC分类号： A61B5/053
CPC分类号： A61B5/04001 , A61B5/0051 , A61B5/0531 , A61B5/14521 , A61B5/4076 , G06F19/00
摘要： A method for assessing sudomotor function of a patient for evaluating diabetic and autonomous neuropathy is disclosed. The method is performed in a system comprising electrodes intended to be placed on different regions of the patient body, and an adjustable DC source. The method includes applying on the electrodes DC voltage pulses of varying voltage values in order to stress sweat glands, the voltage pulses lasting given durations allowing the stabilization of electrochemical phenomena in the body, near the electrodes; collecting data representative of the current between the electrodes, and of the potential generated on the electrodes for the different DC voltages; from the data, computing results representative of the electrochemical skin conductance of the patient; reconciling the latter data with reference data obtained in the same conditions on patients identified as suffering or not from sudomotor, and identifying the patient as suffering or not from sudomotor dysfunction.
摘要翻译： 公开了评估患者糖尿病和自主神经病变患者的运动功能的方法。 该方法在包括旨在放置在患者身体的不同区域上的电极和可调节DC源的系统中进行。 该方法包括在电极上施加具有变化电压值的DC电压脉冲，以便压迫汗腺，持续给定持续时间的电压脉冲，允许在电极附近稳定身体中的电化学现象; 收集表示电极之间的电流的数据，以及针对不同DC电压在电极上产生的电位; 从数据，计算结果代表患者的电化学皮肤电导率; 将后一数据与在相同条件下获得的患者鉴定为患有或不来自患者的参考数据进行调节，并将患者识别为患有或不起因于运动功能障碍的患者。
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