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公开(公告)号：US20180273504A1
公开(公告)日：2018-09-27
申请号：US15547228
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC分类号： C07D401/04 , A61P29/00 , A61P37/06 , C07D401/14 , C07D417/14 , C07D405/14 , C07D413/14
CPC分类号： C07D401/04 , A61P29/00 , A61P37/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrro-lopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.
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公开(公告)号：US20150291554A1
公开(公告)日：2015-10-15
申请号：US14439478
申请日：2013-11-01
申请人： PFIZER INC.
发明人： John Robert Springer , Balekudru Devadas , Danny James Garland , Margaret Lanahan Grapperhaus , Seungil Han , Susan Landis Hockerman , Robert Owen Hughes , Eddine Saiah , Mark Edward Schnute , Shaun Raj Selness , Daniel Patrick Walker , Zhao-Kui Wan , Li Xing , Christoph Wolfgang Zapf , Michelle Ann Schmidt
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
摘要翻译： 本文公开的是与布鲁顿酪氨酸激酶（BTK）形成共价键的化合物。 公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用BTK抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫性疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。
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公开(公告)号：US10815213B2
公开(公告)日：2020-10-27
申请号：US16296319
申请日：2019-03-08
申请人： Pfizer Inc.
发明人： John Robert Springer , Balekudru Devadas , Danny James Garland , Margaret Lanahan Grapperhaus , Seungil Han , Susan Landis Hockerman , Robert Owen Hughes , Eddine Saiah , Mark Edward Schnute , Shaun Raj Selness , Daniel Patrick Walker , Zhao-Kui Wan , Li Xing , Christoph Wolfgang Zapf , Michelle Ann Schmidt
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4155 , A61K31/454 , A61P29/00 , A61P35/00
摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I)
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公开(公告)号：US10426135B2
公开(公告)日：2019-10-01
申请号：US16268857
申请日：2019-02-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , A01K5/01 , B65D77/20 , B65D25/04 , B65D1/34 , A01K7/00 , A23K20/00 , A23K50/48 , B65D1/36 , B65D25/18 , B65D85/00
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US20170283393A1
公开(公告)日：2017-10-05
申请号：US15624969
申请日：2017-06-16
申请人： Pfizer Inc.
发明人： John Robert Springer , Balekudru Devadas , Danny James Garland , Margaret Lanahan Grapperhaus , Seungil Han , Susan Landis Hockerman , Robert Owen Hughes , Eddine Saiah , Mark Edward Schnute , Shaun Raj Selness , Daniel Patrick Walker , Zhao-Kui Wan , Li Xing , Christoph Wolfgang Zapf , Michelle Ann Schmidt
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseeases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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6.发明申请公开(公告)号：US20190387710A1
公开(公告)日：2019-12-26
申请号：US16563022
申请日：2019-09-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： A01K5/01 , B65D25/18 , B65D25/04 , B65D1/36 , B65D1/34 , A01K7/00 , B65D77/20 , A23K20/00 , A23K50/48 , C07D471/04 , C07D401/14
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US10336748B2
公开(公告)日：2019-07-02
申请号：US15546887
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC分类号： C07D471/04
摘要： The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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8.发明申请公开(公告)号：US20190150401A1
公开(公告)日：2019-05-23
申请号：US16268857
申请日：2019-02-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： A01K5/01 , B65D77/20 , B65D25/04 , B65D1/34 , A01K7/00 , B65D25/18 , A23K20/00 , A23K50/48 , B65D1/36
CPC分类号： A01K5/0121 , A01K7/00 , A23K20/00 , A23K50/48 , B65D1/34 , B65D1/36 , B65D25/04 , B65D25/18 , B65D77/2024 , B65D85/70 , B65D2577/205 , C07D401/14 , C07D471/04
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US10227346B2
公开(公告)日：2019-03-12
申请号：US15889296
申请日：2018-02-06
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand Jal Unwalla
IPC分类号： A61K31/437 , A61K31/4353 , C07D471/04 , C07D401/14
摘要： The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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公开(公告)号：US20180002330A1
公开(公告)日：2018-01-04
申请号：US15546887
申请日：2016-01-29
申请人： Pfizer Inc.
发明人： Mark Edward Schnute , Andrew Christopher Flick , Peter Jones , Neelu Kaila , Scot Richard Mente , John David Trzupek , Michael L. Vazquez , Goran Mattias Wennerstal , Li Xing , Edouard Zamaratski , Liying Zhang , Rayomand J. Unwalla
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.
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